Ava Nasrollahi,Yao Yao
Ava Nasrollahi
The blood-brain barrier (BBB) is a dynamic structure that maintains brain homeostasis. BBB breakdown is a key pathological hallmark of almost all neurological diseases. Although the regulation of BBB integrity by different cells has been ex...
Hans Peter Bächinger,Sergei P Boudko
Hans Peter Bächinger
The collagen triple helix is one of the structurally simplest protein motifs that still holds a lot of secrets. The Gly-X-Y repeat is a business card of collagens, where Gly is required for the tight packing of three helices into a superhel...
Inhibition of the MRTF-A/SRF signaling axis alleviates vocal fold scarring [0.03%]
抑制MRTF-A/SRF信号轴可缓解声带瘢痕形成
Ryan M Friedman,Huy D Truong,Matthew R Aronson et al.
Ryan M Friedman et al.
Vocal fold scarring, the most common cause of poor voice after airway injury, involves the transition of vocal fold fibroblasts to contractile myofibroblasts. Vocal fold myofibroblasts can be characterized by significant extracellular matri...
Role of syndecan-4 in angiogenesis and vasculogenic mimicry in triple negative breast cancer cells [0.03%]
syndecan-4在三阴性乳腺癌细胞血管生成和血管样形成中的作用
Jessica Oyie Sousa Onyeisi,Heba M El-Shorafa,Burkhard Greve et al.
Jessica Oyie Sousa Onyeisi et al.
Syndecan-4 (SDC4), a heparan sulfate proteoglycan, is aberrantly expressed in breast cancer and plays a significant role in tumor progression by influencing cell proliferation and promoting invasive growth. This study aimed to characterize ...
Dystrophic Epidermolysis Bullosa - from biochemistry to interventions [0.03%]
dystrophic表皮松解症的生物化学及治疗方法
Alexander Nyström
Alexander Nyström
The skin, as a barrier organ meeting constant mechanical challenges, is equipped with multiple adhesive structures that collectively support resilient, yet flexible attachment of its epithelium -the epidermis to its mesenchyme - the dermis....
Andrew Leask,Richard J Stratton
Andrew Leask
Spatial Localization of Collagen Hydroxylated Proline Site Variation as an Ancestral Trait in the Breast Cancer Microenvironment [0.03%]
乳腺癌微环境中的胶原羟化脯氨酸位点变异的空间定位作为祖先性状
Harrison Taylor,Laura Spruill,Heather Jensen-Smith et al.
Harrison Taylor et al.
Collagen stroma interactions within the extracellular microenvironment of breast tissue play a significant role in breast cancer, including risk, progression, and outcomes. Hydroxylation of proline (HYP) is a common post-translational modif...
Decoding the MMP14 Integrin Link: Key Player in the Secretome Landscape [0.03%]
解码MMP14整合素连接：分泌组景观中的关键因素
Stephan Niland,Johannes A Eble
Stephan Niland
Rapid progress has been made in the exciting field of secretome research in health and disease. The tumor secretome, which is a significant proportion of the tumor proteome, is secreted into the extracellular space to promote intercellular ...
CD45+/ Col I+ Fibrocytes: Major Source of Collagen in the Fibrotic Lung, but not in Passaged Fibroblast Cultures [0.03%]
CD45+/ColI+纤维母细胞：肺纤维化中胶原的主要来源，而不是传代成纤维细胞系中的来源
Charles F Reese,Monika Gooz,Zoltan Hajdu et al.
Charles F Reese et al.
The role of cells of the hematopoietic lineage in fibrosis is controversial. Here we evaluate the contribution of Col I+/CD45+ cells (fibrocytes) to lung fibrosis. Systemic bleomycin treatment was used to induce fibrosis in a bone marrow tr...
Endothelial cell (EC)-specific CTGF/CCN2 Expression Increases EC Reprogramming and Atherosclerosis [0.03%]
内皮细胞(EC)特异性CTGF/CCN2表达增加EC重编程和动脉粥样硬化
Feifei Li,Sandeep Kumar,Anastassia Pokutta-Paskaleva et al.
Feifei Li et al.
Arterial endothelial cells (ECs) reside in a complex biomechanical environment. ECs sense and respond to wall shear stress. Low and oscillatory wall shear stress is characteristic of disturbed flow and commonly found at arterial bifurcation...