The functional role of the extracellular matrix in inflammatory bowel disease associated gut fibrosis [0.03%]
炎症性肠病相关肠道纤维化中外基质的功能作用
Si-Nan Lin,Jie Wang,Pranab K Mukherjee et al.
Si-Nan Lin et al.
Intestinal fibrosis is characterized by the excessive accumulation of extracellular matrix (ECM) in the bowel wall. Complications, such as strictures that require surgical intervention in a large proportion of patients, are considered an in...
Interactions between cancer-associated fibroblasts and the extracellular matrix in oesophageal cancer [0.03%]
癌相关成纤维细胞和食管癌中细胞外基质之间的相互作用
Subashan Vadibeler,Shannique Clarke,Su M Phyu et al.
Subashan Vadibeler et al.
Stromal components of the tumour microenvironment, such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM), are actively involved in tumorigenesis. CAFs and the ECM co-evolve with resultant molecular and mechanical p...
Differential Modulation of Endothelial Cell Functionality by LRP1 Expression in Fibroblasts and Cancer-Associated Fibroblasts via Paracrine signals and Matrix Remodeling [0.03%]
纤维细胞和癌相关成纤维细胞通过旁分泌信号和基质重塑差异调节内皮细胞功能性的LRP1表达作用机制研究
Julie Martin,Auréana Falaise,Sara Faour et al.
Julie Martin et al.
LRP1 is a multifunctional endocytosis receptor involved in the regulation of cancer cell aggressiveness, fibroblast phenotype and angiogenesis. In breast cancer microenvironment, cancer-associated fibroblasts (CAFs) play a crucial role in m...
ECM, integrins, and DDRs: A nexus of cancer progression, therapy, and future directions [0.03%]
基质、整合素和DDR：癌症进展、治疗及其未来方向的汇聚点
Md Al Azim,Julie S Di Martino
Md Al Azim
Collagen is the most abundant protein in mammals, significantly contributing to cancer progression. Cells express two primary well-conserved collagen receptors, integrins and discoidin domain receptors (DDRs), which bind collagen on distinc...
Sandhya Srinivasan,David R Sherwood
Sandhya Srinivasan
Type IV collagen is a large triple helical molecule that forms a covalently cross-linked network within basement membranes (BMs). Type IV collagen networks play key roles in mechanically supporting tissues, shaping organs, filtering blood, ...
Brain vascular basement membrane: comparison of human and mouse brain at the transcriptomic and proteomic levels [0.03%]
脑血管基底膜：人类与小鼠大脑的转录组和蛋白质组比较
Nan Zhao,Alexander F Pessell,Tracy D Chung et al.
Nan Zhao et al.
The cerebrovascular basement membrane (BM) is a key component of the blood-brain barrier (BBB). The BM provides structural support for brain microvascular endothelial cells and the supporting cells of the neurovascular unit, and facilitates...
Antonio Inforzato,Anthony J Day
Antonio Inforzato
Pentraxin-3 (PTX3) is a secreted protein with roles in the stabilisation of hyaluronan-rich extracellular matrices involved in reproductive biology and inflammatory processes, as well as additional functions in innate immunity and cancer. O...
Toward a rational therapeutic for elastin related disease: key considerations for elastin based regenerative medicine strategies [0.03%]
弹性蛋白相关疾病的合理治疗：弹性蛋白为基础的再生医学策略中的关键考虑因素
Meysam Ganjibakhsh,Yanina Tkachenko,Russell H Knutsen et al.
Meysam Ganjibakhsh et al.
Elastin is a connective tissue protein, produced from the ELN gene, that provides elasticity and recoil to tissues that stretch, such as the large arteries of the body, lung parenchyma, skin, ligaments and elastic cartilages. It is produced...
Structural insights on perlecan and Schwartz-Jampel syndrome [0.03%]
关于硫酸软骨素和Schwartz-Jampel综合征的结构见解
Anil A Sohail,M Kristian Koski,Lloyd W Ruddock
Anil A Sohail
Perlecan is an essential multi-domain, disulfide bond rich basement membrane protein. Mutations in perlecan cause Schwartz-Jampel syndrome and dyssegmental dysplasia. While there has been a large body of experimental work reported on perlec...
Circulating collagen type I fragments as specific biomarkers of cardiovascular outcome risk: Where are the opportunities? [0.03%]
I型胶原片段作为心血管结局风险的特异性生物标志物：机遇何在？
Emily M Martin,Joan Chang,Arantxa González et al.
Emily M Martin et al.
Collagen type I (COL1) is the most abundant protein in the human body and is a main component in the extracellular matrix. The COL1 structure vastly influences normal tissue homeostasis and changes in the matrix drive progression in multipl...