Collagen Diversity in Human Skin: Aging, Wound Healing, And Disorders [0.03%]
人类皮肤中的胶原多样性：老化、伤口愈合及疾病
Mélanie Salamito,Valérie Haydont,Hervé Pageon et al.
Mélanie Salamito et al.
Collagen is an essential skin protein, accounting for 75% of the skin's dry weight. The collagen superfamily encompasses a diverse group of proteins with a variety of structures that fulfil a wide range of functions. The half-life of collag...
Drosophila Col4a1 Glycine mutations highlight allelic heterogeneity and mechanistic pleiotropy [0.03%]
果蝇Col4a1甘氨酸突变体揭示了等位基因异质性和机制多效性
Angus Nichols,Besaiz J Sánchez-Sánchez,Stefania Marcotti et al.
Angus Nichols et al.
Collagen IV (Col4) is a heterotrimer containing a triple helical domain broken up by short interruptions. Mutation of Glycine residues within the Glycine-X-Y triple helical repeat leads to genetically dominant disease in humans that affects...
ECM proteins shape topographical patterns in the basement membrane of Drosophila wing discs [0.03%]
表皮基底膜的构象模式塑造了果蝇翅盘中的 ECM 蛋白
K Yanín Guerra Santillán,Christian Dahmann,Elisabeth Fischer-Friedrich
K Yanín Guerra Santillán
The basal surface of epithelial tissues is attached to a thin network of macromolecules known as the basement membrane. The core components of the basement membrane - Collagen IV, Laminin, Perlecan, and Nidogen - are conserved extracellular...
Role of extracellular space and matrix remodeling in cardiac amyloidosis [0.03%]
心脏淀粉样变性中细胞外空间和基质重塑的作用
Francesca Lavatelli,Loredana Marchese,Palma Patrizia Mangione et al.
Francesca Lavatelli et al.
The hallmark of amyloid diseases is deposition of misfolded proteins as amyloid fibrils in the interstitium of target organs. Amyloid deposits surround cells, distorting the micro and macro-architecture of the extracellular space and profou...
Alana Stevenson Harris,Rachel Lennon,Jean-Marc Schwartz
Alana Stevenson Harris
Basement membranes (BMs) are dense extracellular matrix scaffolds that support cells. Their composition, structure and dynamic regulation are vital for tissue health and altered in human disease. The expansion of experimental and analytical...
Around the collagen triple helix: an introduction to studying associated genetic and acquired diseases [0.03%]
胶原三螺旋及其相关遗传和获得性疾病的介绍
Sergei P Boudko
Sergei P Boudko
The triple helix structure of collagen is the most abundant motif found in our bodies. It is believed to have emerged during the transition from unicellular to multicellular animal organisms, known as metazoans, and has evolved into various...
Collagen IV Biosynthesis: Intracellular Choreography of Post-Translational Modifications [0.03%]
IV型胶原的生物合成：翻译后修饰的细胞内编舞
Yoshihiro Ishikawa,Rachel Lennon,Federico Forneris et al.
Yoshihiro Ishikawa et al.
Collagen IV, an essential and evolutionarily conserved component of basement membranes, is one of the most extensively post-translationally modified proteins. Despite substantial research on fibrillar collagen biosynthesis, our understandin...
Paracrine regulations of IFN-γ secreting CD4+ T cells by lumican and biglycan are protective in allergic contact dermatitis [0.03%]
补体蛋白lumican和biglycan通过旁分泌调节IFN-γ分泌的CD4+T细胞在过敏性接触性皮炎中发挥保护作用
George Maiti,Jihane Frikeche,Cynthia Loomis et al.
George Maiti et al.
Allergic contact dermatitis (ACD) is a delayed-type IV hypersensitivity response driven by innate and adaptive immune cells. While specific immune regulations of these cell types are amply elucidated, their regulations by extracellular matr...
A complex relationship between the architecture of the basement membrane, its mechanical properties, and its ability to shape the Drosophila egg [0.03%]
基底膜的结构、机械性能及其塑形果蝇卵的能力之间的复杂关系
Mitchell T Anderson,Sally Horne-Badovinac
Mitchell T Anderson
Basement membranes (BMs) are planar extracellular matrices that line the basal surfaces of epithelia and are essential components of most organs. During development, BMs can also play instructive roles in shaping the tissues to which they b...
Mechanical control of breast cancer malignancy by promotion of mevalonate pathway enzyme synthesis [0.03%]
机械控制乳腺癌恶性程度：通过促进麦角醇代谢途径酶类的合成实现
Sara Göransson,Helene Olofsson,Henrik J Johansson et al.
Sara Göransson et al.
In breast cancer, mechanotransduction from stiffened extracellular matrix (ECM) drives proliferation and invasion. Here, we use a model of matrix stiffening mimicking progression of breast ductal carcinoma in situ to invasive ductal carcino...