Biomechanical and compositional basement membrane defects due to a Col4a1 mutation affect cardiac morphology and function [0.03%]
COL4A1突变导致的基底膜生物力学和组成缺陷影响心脏形态和功能
Erin Boland,Anna Hoyle,Olivia Robertson-Gray et al.
Erin Boland et al.
Collagen IV is a major constituent of basement membranes and mutations in the genes COL4A1 and COL4A2 present clinically as a variable, multi-system disorder called COL4A1 (Gould) syndrome. Evidence from case reports supports a cardiac comp...
Evidence for the major role of PH4⍺EFB in the prolyl 4-hydroxylation of Drosophila collagen IV [0.03%]
PH4αEFB在果蝇IV型胶原脯氨酰4-羟化作用中起主要作用的证据
Yoshihiro Ishikawa,Melissa A Toups,Marwan Elkrewi et al.
Yoshihiro Ishikawa et al.
Collagens are fundamental components of extracellular matrices, requiring precise intracellular post-translational modifications for proper function. Among the modifications, prolyl 4-hydroxylation is critical to stabilise the collagen trip...
Exploring Basement Membrane Dynamics through Cross-Scale Imaging, Manipulation, and Molecular Mapping [0.03%]
通过跨尺度成像、操纵和分子映射探索基底膜动力学
Kohei Omachi,Hironobu Fujiwara
Kohei Omachi
The basement membrane (BM), a specialized extracellular matrix (ECM), provides structural support for epithelial, endothelial, and other parenchymal cells. Once considered a static scaffold, the BM is now recognized as a dynamic and complex...
Laminin γ1 chain is essential for the cardiorespiratory and muscular systems [0.03%]
层粘连蛋白γ1链对心肺和肌肉系统是必不可少的
Kinga I Gawlik,Deniz A Bölükbas,Fatima Daoud et al.
Kinga I Gawlik et al.
Laminins are basement membrane components that regulate a plethora of biological processes. Despite decades of research, the exact roles of laminins in different tissues and in organogenesis remain to be elucidated. Here, we investigated th...
Retraction Notice for "Novel regulatory roles of small leucine-rich proteoglycans in remodeling of the uterine cervix in pregnancy" [Matrix Biology, Volume 105, January 2022, Pages 53-71] [0.03%]
关于《妊娠期间子宫颈重塑中新型小型亮氨酸丰富蛋白聚糖的调控作用》的撤稿声明
Mariano Colon-Caraballo,Nicole Lee,Shanmugasundaram Nallasamy et al.
Mariano Colon-Caraballo et al.
Loss of col4a1 in zebrafish recapitulates the cerebrovascular phenotypes associated with monogenic cerebral small vessel disease [0.03%]
斑马鱼col4a1丢失再现单基因脑小血管病相关的脑血管表型
Daisy Flatman,Richard W Naylor,Siobhan Crilly et al.
Daisy Flatman et al.
Cerebral small vessel disease (cSVD) is a major cause of vascular dementia and stroke. Our understanding of cSVD pathophysiology is incomplete and our ability to treat patients is limited. Pathogenic variants in type IV collagen alpha 1 (CO...
Corrigendum to "Decorin deficiency promotes epithelial-mesenchymal transition and colon cancer metastasis" [Matrix Biology Volume 95 (2021)1-14] [0.03%]
关于“ decorin 缺失促进上皮间质转化和结肠癌转移”的勘误(矩阵生物学专辑95卷(2021)1-14期）
Liping Mao,Jinxue Yang,Jiaxin Yue et al.
Liping Mao et al.
Basement Membrane Structure and Function: Relating Biology to Mechanics [0.03%]
基底膜结构与功能：从生物学角度到力学角度的研究关系
Andrea Page-McCaw,Nicholas Ferrell
Andrea Page-McCaw
Basement membranes are key mediators of many biological processes such as epithelial morphogenesis, kidney filtration, and muscle function among others. Basement membranes provide structural support to tissues so understanding their mechani...
Heparan sulfate N-deacetylase/N-sulfotransferase-1 regulates glioblastoma cell migration and invasion [0.03%]
肝素硫酸盐N-脱乙酰基/N-磺基转移酶-1调节胶质母细胞瘤细胞的迁移和侵袭
Argyris Spyrou,Ananya Roy,Anqi Xiong et al.
Argyris Spyrou et al.
The glioblastoma (GBM) microenvironment undergoes adaptations to support tumor progression, including a dysregulated extracellular matrix, with altered heparan sulfate (HS) proteoglycans. We investigated N-deacetylase/N-sulfotransferase-1 (...
Matilda Thuringer,Roy Zent,Rachel Lennon et al.
Matilda Thuringer et al.
The primary function of the respiratory system is the exchange of oxygen and carbon dioxide across the alveolar-capillary barrier in the distal lung. This structure is composed of alveolar epithelial cells (type 1 and type 2) and capillary ...