Furin-like cleavage at the C1-C2 linker region of the ⍺3 chain is not required for collagen VI assembly [0.03%]
胶原VI装配不需要α3链C1-C2连接区的Furin样切割作用
Arthur Lauri Pasanen-Zentz,Mengjie Zhu,Sebastian Schmitz et al.
Arthur Lauri Pasanen-Zentz et al.
Collagen VI is a heterotrimeric, ubiquitously expressed microfibrillar collagen with a complex intracellular and extracellular assembly process. In addition to a short collagenous region, it is primarily composed of von Willebrand factor A ...
Zebrafish col4a1 loss-of-function models mirror key neurovascular and ocular features of COL4A1/A2 syndrome and enable human variants assessment in vivo [0.03%]
COL4A1功能丧失斑马鱼模型模拟COL4A1/A2综合征的关键神经血管和眼部特征并在活体中鉴定人类变异型
Graziamaria Paradisi,Valeria Bonavolontà,Martina Venditti et al.
Graziamaria Paradisi et al.
Pathogenic variants in COL4A1 and COL4A2, encoding type IV collagen α1 and α2 chains-core components of all basement membranes-cause a multisystem disorder with variable expressivity. Affected individuals commonly present with cerebral sm...
FAM20C and FAM20A in normal and ectopic mineralization: a focus on oro-renal syndromes [0.03%]
正常和异位矿化中的FAM20C和FAM20A：以口-肾综合征为重点
Amina Baker,Mohammad Al Tarrass,Christos Chatziantoniou et al.
Amina Baker et al.
FAM20C is part of the FAM20 family and is crucial for phosphorylating secreted proteins. It plays roles in various biological processes, including cellular calcium regulation and cardiovascular function. Pathogenic variants of FAM20C cause ...
Matrix metalloproteinase 13 (MMP-13) processing of type II collagen is altered by antibodies and citrullination found in the early stages of rheumatoid arthritis [0.03%]
类风湿性关节炎早期产生的抗体和瓜氨酸化可改变基质金属蛋白酶13（MMP-13）对II型胶原的降解作用
Anna M Knapinska,Dorota Tokmina-Roszyk,Sabrina Haag et al.
Anna M Knapinska et al.
A subset of rheumatoid arthritis (RA) is the production of autoantibodies, including antibodies to citrullinated proteins (ACPA) and antibodies to type II collagen (AC2A). Type II collagen (COL2) is the major protein in joint cartilage and ...
Phosphorylation of UDP-glucose dehydrogenase increases glycosaminoglycan biosynthesis and promotes tumor cell motility, spheroid growth, and therapeutic resistance [0.03%]
UDP-葡萄糖脱氢酶的磷酸化通过促进肿瘤细胞迁移、类器官生长及治疗抵抗来增加糖胺聚糖生物合成
Asher R Utz,Linlin Ma,Dalton Hilovsky et al.
Asher R Utz et al.
UDP-glucose 6-dehydrogenase (UGDH) is an essential enzyme that catalyzes the oxidation of UDP-glucose to UDP-glucuronate. UGDH is elevated in multiple cancers, including prostate cancer, and is functionally implicated in castration resistan...
Retraction Notice to "RETRACTED: The angiostatic molecule Multimerin 2 is processed by MMP-9 to allow sprouting angiogenesis" [0.03%]
撤销通知："多聚蛋白2作为血管生成分子被MMP-9切割以允许出芽式血管生成"(英文版)撤销
Eva Andreuzzi,Roberta Colladel,Rosanna Pellicani et al.
Eva Andreuzzi et al.
Laminin-511-functionalized fibrin gel enables in-gel proliferation of human induced pluripotent stem cells [0.03%]
功能性层粘连蛋白-511的纤维蛋白凝胶能够使人类诱导多能干细胞在凝胶内增殖
Yukimasa Taniguchi,Mamoru Takizawa,Ayaka Hada et al.
Yukimasa Taniguchi et al.
Fibrin is a biocompatible hydrogel that is widely used as a surgical sealant and as a scaffold for in vitro cell culture. Here, we engineered a heterotrimeric chimera between fibrinogen and laminin-511 by connecting the N-terminal self-poly...
Matrix bound nanovesicles: a great promise for TERM in less than a decade of research [0.03%]
矩阵限制型纳米囊泡：不到十年的研究带来的伤口治疗新希望
Dalila Di Francesco,Diego Mantovani,George Hussey et al.
Dalila Di Francesco et al.
Decellularized extracellular matrix materials have been widely studied for tissue engineering and regenerative medicine (TERM) applications, largely because of their intrinsic bioactivity and immunomodulatory potentials. These properties co...
TRANSMEMBRANE AND MULTIPLEXIN COLLAGENS IN DEVELOPMENT AND PATHOBIOLOGY [0.03%]
跨膜及多功能丝氨酸蛋白酶抑制剂型基质金属蛋白酶作用底物(collagens)家族成员在发育和病理生物学中的功能研究
Taina Pihlajaniemi
Taina Pihlajaniemi
At its best, it is exhilarating to make unexpected discoveries when addressing carefully formed scientific hypotheses. This review depicts my scientific journey in the field of extracellular matrix biology, and more specifically in collagen...
Extracellular matrix architecture promotes immunosuppressive microenvironments in pancreatic cancer [0.03%]
细胞外基质结构促进胰腺癌免疫抑制微环境
Mackenzie K Callaway,Brock J Noonan,Kaylee L Schwertfeger et al.
Mackenzie K Callaway et al.
Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer with poor clinical outcomes, due in part to altered fibrotic environments and striking immune dysfunction. Physical properties within tumors, such as aligned extracellular matri...