Chondrocalcin is internalized by chondrocytes and triggers cartilage destruction via an interleukin-1β-dependent pathway [0.03%]
软骨钙结晶由软骨细胞内吞并通过依赖于白细胞介素-1β的途径触发软骨破坏
Claudie Bantsimba-Malanda,Justine Cottet,Patrick Netter et al.
Claudie Bantsimba-Malanda et al.
Chondrocalcin is among the most highly synthesized polypeptides in cartilage. This protein is released from its parent molecule, type II pro-collagen, after secretion by chondrocytes. A participation of extracellular, isolated chondrocalcin...
Why cellular stress suppresses adipogenesis in skeletal tissue, but is ineffective in adipose tissue: control of mesenchymal cell differentiation via integrin binding sites in extracellular matrices [0.03%]
为什么细胞应激会抑制骨骼组织中的脂肪生成而在脂肪组织中却无效：通过细胞外基质中的整合素结合位点控制间充质细胞分化
Vladimir Volloch,Bjorn R Olsen
Vladimir Volloch
This Perspective addresses one of the major puzzles of adipogenesis in adipose tissue, namely its resistance to cellular stress. It introduces a concept of "density" of integrin binding sites in extracellular matrix, proposes a cellular sig...
Leucine rich amelogenin peptide alters ameloblast differentiation in vivo [0.03%]
赖氨酸丰富釉原蛋白肽改变体内釉质细胞分化
Jonathan Stahl,Yukiko Nakano,Seong-Oh Kim et al.
Jonathan Stahl et al.
Highly mineralized tooth enamel develops from an extracellular matrix chiefly comprised of amelogenins formed by splicing of 7 (human) or 9 (rodent) exons secreted from specialized epithelial cells known as ameloblasts. Here we examined the...
Michael B Duncan
Michael B Duncan
The extracellular matrix undergoes extensive remodeling during hepatocellular carcinoma and functions as a critical component of the tumor microenvironment by providing a substratum for cell adhesion and serving as a reservoir for a variety...
Renato V Iozzo
Renato V Iozzo
Identification of a Ninein (NIN) mutation in a family with spondyloepimetaphyseal dysplasia with joint laxity (leptodactylic type)-like phenotype [0.03%]
九同（NIN）基因变异与松软关节型脊柱骨骺发育不良表型家系的研究
Melanie Grosch,Barbara Grüner,Stephanie Spranger et al.
Melanie Grosch et al.
Spondyloepimetaphyseal dysplasia with joint laxity-leptodactylic type (SEMDJL2) is an autosomal dominant skeletal dysplasia which is characterized by midface hypoplasia, short stature, joint laxity with dislocations, genua valga, progressiv...
The extracellular matrix locally regulates asynchronous concurrent lactation in tammar wallaby (Macropus eugenii) [0.03%]
外基质在袋鼠（Macropus eugenii）局部调节同步哺乳的作用
Stephen S Wanyonyi,Christophe Lefevre,Julie A Sharp et al.
Stephen S Wanyonyi et al.
Asynchronous concurrent lactation (ACL) is an extreme lactation strategy in macropod marsupials including the tammar wallaby, that may hold the key to understanding local control of mammary epithelial cell function. Marsupials have a short ...
Novel combination of collagen dynamics analysis and transcriptional profiling reveals fibrosis-relevant genes and pathways [0.03%]
结合胶原动力学分析和转录组学鉴定与纤维化相关的基因和信号通路
Marjolein E Blaauboer,Claire L Emson,Lars Verschuren et al.
Marjolein E Blaauboer et al.
Collagen deposition is a key process during idiopathic pulmonary fibrosis; however, little is known about the dynamics of collagen formation during disease development. Tissue samples of early stages of human disease are not readily availab...
Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels [0.03%]
decorin蛋白多糖对I型胶原纤维形成、超微结构及力学性能的影响
Shawn P Reese,Clayton J Underwood,Jeffrey A Weiss
Shawn P Reese
The proteoglycan decorin is known to affect both the fibrillogenesis and the resulting ultrastructure of in vitro polymerized collagen gels. However, little is known about its effects on mechanical properties. In this study, 3D collagen gel...
Experience-dependent development of perineuronal nets and chondroitin sulfate proteoglycan receptors in mouse visual cortex [0.03%]
小鼠视觉皮层中依赖经验的神经外网和硫酸软骨素蛋白聚糖受体的发育
Qian Ye,Qing-Long Miao
Qian Ye
Perineuronal nets (PNNs) are extracellular matrix structures consisting of chondroitin sulfate proteoglycans (CSPGs), hyaluronan, link proteins and tenascin-R (Tn-R). They enwrap a subset of GABAergic inhibitory interneurons in the cerebral...