PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response [0.03%]
靶向DNA损伤反应的PARP1-PROTACs在精准肿瘤学中提供新的机遇
Md Sadique Hussain,Gaurav Gupta
Md Sadique Hussain
Marlo K Thompson,Mark H Eggers,Danielle Flores et al.
Marlo K Thompson et al.
Nei endonuclease VIII-like 1 (NEIL1) is a bifunctional human DNA glycosylase that catalyzes the first step of the base excision repair (BER) pathway by recognizing and excising oxidized bases, including thymine glycol and the further oxidat...
Overexpression of the WWE domain of RNF146 modulates poly-(ADP)-ribose dynamics at sites of DNA damage [0.03%]
RNF146的WWE结构域过表达调控DNA损伤部位的poly-(ADP)-核糖动态变化
Rasha Q Al-Rahahleh,Wynand P Roos,Kate M Saville et al.
Rasha Q Al-Rahahleh et al.
Protein poly-ADP-ribosylation (PARylation) is a post-translational modification formed by transferring successive units of ADP-ribose to target proteins to form poly-ADP-ribose (PAR) chains. PAR plays a critical role in the DNA damage respo...
Emerging connections: Poly(ADP-ribose), FET proteins and RNA in the regulation of DNA damage condensates [0.03%]
新兴联系：多（腺苷二磷酸）核糖、FET蛋白和RNA在DNA损伤凝聚体调控中的作用
Silvia Lombardi,Mara Zilocchi,Roland Nicsanu et al.
Silvia Lombardi et al.
Our genome is exposed to thousands of DNA lesions every day, posing a significant threat to cellular viability. To deal with these lesions, cells have evolved sophisticated repair mechanisms collectively known as the DNA damage response. DN...
BRCA1 and BRCA2 in DNA damage and replication stress response: Insights into their functions, mechanisms, and implications for cancer treatment [0.03%]
DNA损伤及复制压力反应中的BRCA1和BRCA2：关于其功能、机制及癌症治疗意义的见解
Ziqi Xu,Haihua Xie,Lizhi Song et al.
Ziqi Xu et al.
Genomic stability is a cornerstone of cellular survival and proliferation. To counter the constant threat posed by endogenous and exogenous DNA-damaging agents, cells rely on a network of intricate mechanisms to safeguard DNA integrity and ...
Nicola P Montaldo,Hilde Loge Nilsen,Diana L Bordin
Nicola P Montaldo
Targeting the DNA damage response (DDR) is a key strategy in cancer therapy, leveraging tumour-specific weaknesses in DNA repair pathways to enhance treatment efficacy. Traditional treatments, such as chemotherapy and radiation, use a broad...
Joining of DNA breaks- interplay between DNA ligases and poly (ADP-ribose) polymerases [0.03%]
DNA双链断裂的连接——DNA连接酶与多(腺苷二磷酸-核糖)聚合酶之间的相互作用
Nicolas Call,Alan E Tomkinson
Nicolas Call
The joining of DNA single- and double-strand breaks (SSB and DSB) is essential for maintaining genome stability and integrity. While this is ultimately accomplished in human cells by the DNA ligases encoded by the LIG1, LIG3 and LIG4 genes,...
Reversible association of ubiquitin with PCNA is important for template switching in S. cerevisiae [0.03%]
泛素与PCNA的可逆结合在酿酒酵母模板切换中起重要作用
Cindy Meister,Ronald P Wong,Zhi-Hoon Park et al.
Cindy Meister et al.
Polyubiquitylation of the replication factor PCNA activates the replicative bypass of DNA lesions via an error-free pathway involving template switching. However, the mechanism by which the K63-linked polyubiquitin chains facilitate damage ...
Weaponizing CRISPR/Cas9 for selective elimination of cells with an aberrant genome [0.03%]
武器化CRISPR/Cas9选择性清除基因组异常的细胞
Sara Tavella,Alessia di Lillo,Anastasia Conti et al.
Sara Tavella et al.
The CRISPR/Cas9 technology is a powerful and versatile tool to disrupt genes' functions by introducing sequence-specific DNA double-strand breaks (DSBs). Here, we repurpose this technology to eradicate aberrant cells by specifically targeti...
Stained DNA Dot Detection (SD3): An automated tool for quantifying fluorescent features along single stretched DNA molecules [0.03%]
染色DNA点检测（SD3）：量化单根拉伸DNA分子上荧光特征的自动化工具
Obed A Aning,Albertas Dvirnas,My Nyblom et al.
Obed A Aning et al.
The main information in DNA is its four-letter sequence that builds up the genetic information and that is traditionally read using sequencing methodologies. DNA can, however, also carry other important information, such as epigenetic marks...