The differential roles of rad9 alternatively spliced forms in double- strand DNA break repair during Drosophila meiosis [0.03%]
辐照诱发的果蝇减数分裂中RAD9可变剪辑形式在双链DNA损伤修复中发挥不同作用
Bareket Goldstein,Suad Sheikh-Suliman,Anna Bakhrat et al.
Bareket Goldstein et al.
The 9-1-1 complex, comprising the Rad9, Hus1 and Rad1 proteins, is believed to operate as a component of a DNA damage checkpoint pathway. Our initial analysis of the Drosophila hus1 gene showed that Hus1 plays a dual role in meiosis, regula...
Yingying Meng,Lee Zou
Yingying Meng
R-loops are dynamic three-stranded nucleic acid structures that form naturally during transcription. These structures typically arise when the newly synthesized RNA hybridizes with the DNA template strand, displacing the non-template DNA st...
Corrigendum to "Role of NEIL1 in genome maintenance" [DNA Repair 148 (2025) 103820] [0.03%]
“NEIL1在基因组维护中的作用”[DNA修复148(2025）103820]的勘误表
Amanda K McCullough,Irina G Minko,Michael M Luzadder et al.
Amanda K McCullough et al.
Published Erratum
DNA repair. 2025 Apr 9:149:103835. DOI:10.1016/j.dnarep.2025.103835 2025
Werner helicase as a therapeutic target in mismatch repair deficient colorectal cancer [0.03%]
错配修复缺陷型结直肠癌患者的 Werner 解旋酶作为治疗靶点
Suisui Hao,Zhaojin Liu,Heinz-Josef Lenz et al.
Suisui Hao et al.
Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths in the United States. A key driver of CRC development is microsatellite instability (MSI), which is caused by DNA mismatch repair deficiency and characterized by ...
PARP inhibitors in ovarian cancer: Mechanisms of resistance and implications to therapy [0.03%]
卵巢癌中DNA损伤修复通路改变及PARP抑制剂耐药机制的研究进展
Sanat Kulkarni,Nethmin Seneviratne,Çağla Tosun et al.
Sanat Kulkarni et al.
Advanced epithelial ovarian cancer of the high-grade serous subtype (HGSOC) remains a significant clinical challenge due to the development of resistance to current platinum-based chemotherapies. PARP1/2 inhibitors (PARPi) exploit the well-...
Alberto Ciccia,Alessandro Vindigni
Alberto Ciccia
Transport of DNA repair proteins to the cell nucleus by the classical nuclear importin pathway - a structural overview [0.03%]
DNA修复蛋白通过经典核输入途径运输到细胞核的结构综述
Marcos R M Fontes,Fábio F Cardoso,Bostjan Kobe
Marcos R M Fontes
DNA repair is a crucial biological process necessary to address damage caused by both endogenous and exogenous agents, with at least five major pathways recognized as central to this process. In several cancer types and other diseases, incl...
Modulation of OGG1 enzymatic activities by small molecules, promising tools and current challenges [0.03%]
小分子对OGG1酶活性的调节，有前景的工具和当前挑战
Xavier Renaudin,Anna Campalans
Xavier Renaudin
Oxidative DNA damage, resulting from endogenous cellular processes and external sources plays a significant role in mutagenesis, cancer progression, and the pathogenesis of neurological disorders. Base Excision Repair (BER) is involved in t...
Junyi Chen,Wenkang Zhang,Yuqi Ma et al.
Junyi Chen et al.
Over the past two decades, there has been intense debate regarding whether DNA double-strand breaks (DSBs) maintain a relatively stable position or cluster in mammalian cells. The clustering of DSB and its spatiotemporal properties remain u...
Repair pathway coordination from gap filling by polβ and subsequent nick sealing by LIG1 or LIG3α governs BER efficiency at the downstream steps [0.03%]
由polβ补缺以及随后的LIG1或LIG3α封口密封控制下游步骤的BER效率修复途径协调
Melike Çağlayan
Melike Çağlayan
Base excision repair (BER) is the critical mechanism for preventing mutagenic and lethal consequences of single base lesions generated by endogenous factors or exposure to environmental hazards. BER pathway involves multi-step enzymatic rea...