An economical and rapid method of comet assay and micronucleus cytome assay for genotoxicity biomonitoring using clam, Gafrarium divaricatum (Gmelin, 1791) [0.03%]
利用泥螺（Gafrarium divaricatum）进行基因毒性生物监测的彗星实验和微核细胞测定的经济快捷方法研究
M Harshavarthini,Edward Inpent Campal,Shubra Singh et al.
M Harshavarthini et al.
The comet assay or single-cell gel electrophoresis and the micronucleus cytome assay have emerged as widely used methods for measuring DNA damage and cytotoxicity in genotoxicity testing and biomonitoring studies. The relative occurrence of...
Rebecca Roddan,Lucy R Henderson,Malitha Ratnaweera et al.
Rebecca Roddan et al.
Impediments to faithful transcription must be resolved to ensure accurate gene expression and safeguard normal cellular function. Dedicated DNA repair pathways have therefore evolved to remove transcription-blocking DNA damage, targeted to ...
From cooperation to conflicts - A complicated relationship between transcription and replication [0.03%]
从合作到冲突-转录与复制的复杂关系
Syed Shahid Musvi,Tatiana N Moiseeva
Syed Shahid Musvi
A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated initiation of DNA replication result in transcription replication conflicts and DNA damag...
Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies [0.03%]
合成的细胞毒性谱分析共hesin突变体强调了重组依赖性
Rafaela Horbach Marodin,Ecaterina Cozma,Sivan Reytan-Miron et al.
Rafaela Horbach Marodin et al.
Cohesin maintains genome integrity through its ability to bind and link DNA molecules via a Structural Maintenance of Chromatin (SMC) activity. These effects are manifested through its major function in sister chromatid cohesion, but also t...
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer [0.03%]
揭开cGAS的机制面纱：癌症中DNA损伤和免疫识别的新见解
Min-Guk Cho,Gaorav P Gupta
Min-Guk Cho
The innate immune sensing system plays a critical role in recognizing and responding to DNA damage, which is a key factor in cancer development and progression. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway...
Penny Jeggo,Bennett Van Houten
Penny Jeggo
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models [0.03%]
DNA拓扑异构酶IIβ抑制可阻断DNA末端外切加工 并且能够与BRCA1缺陷模型中的PARP抑制剂协同作用
Rosa Camarillo,Rosario Prados-Carvajal,Andrés Cruz-García et al.
Rosa Camarillo et al.
DNA end resection is a critical step that governs how a broken chromosome will be repaired. As such, it is heavily regulated by multiple cellular signals and processes. Alterations in the regulation of DNA end resection have consequences fo...
FBH1 and the replication stress response: Implications for genome stability and cancer development [0.03%]
FBH1与复制压力反应：基因组稳定性和癌症发生的意义
Joshua L Turner,Jennifer M Mason
Joshua L Turner
The replication stress response plays important roles in maintaining genome stability.In this review article, we focus on the role of FBH1 in the replication stress response and promoting death in cells with excessive DNA damage. FBH1-defic...
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers [0.03%]
聚ADP核糖聚合酶和腺苷二磷酸核糖水解酶在癌症治疗中的作用：从药物靶点到生物标志物
Joséphine Groslambert,Kira Schützenhofer,Luca Palazzo et al.
Joséphine Groslambert et al.
The PARP family of enzymes catalyzes ADP-ribosylation, a modification of macromolecules, and plays a crucial role in DNA damage repair. The landmark discovery that cancer cells deficient in homologous recombination repair are highly sensiti...
Proofreading of mismatches within primer-template junctions by Escherichia coli DNA polymerase I in vitro and in vivo [0.03%]
大肠杆菌DNA聚合酶I在体内和体外通过模板转换对引物-模板交界处错配的校正作用
Hui-Lan Chang,Kang-Yi Su,Steven D Goodman et al.
Hui-Lan Chang et al.
Escherichia coli DNA polymerase I (Pol I) possesses a 3' to 5' proofreading function. Using a non-inhibitory in vitro proofreading assay and MALDI-TOF MS analysis, we demonstrated the Pol I proofreading function was effective at removal of ...