Michele Giaquinto,Alessandro Framarini,Andrea Parlante et al.
Michele Giaquinto et al.
R-loops are atypical three-stranded nucleic acid structures composed of a stretch of DNA:RNA hybrids that displace the unpaired, single DNA strand, resulting in the formation of a characteristic loop structure. When properly regulated, R-lo...
DNA damage repair (DDR) related prognostic risk model in multiple myeloma based on single-cell and bulk sequencing [0.03%]
基于单细胞和批量测序的骨髓瘤中与DNA损伤修复相关的预后风险模型
Hongxiu Liu,Zhihua Li,Yihua Wang et al.
Hongxiu Liu et al.
Genomic rearrangements and instability are key pathological features of multiple myeloma (MM). However, the origins of DNA damage in MM and its impact on disease progression remain incompletely understood. Here, we screened DNA damage repai...
Sijia Wang,Yukang Wu,Wen Zong et al.
Sijia Wang et al.
Poly(ADP-ribose) polymerase 1 (PARP1), the founding member of the PARP superfamily, is an enzyme with poly-ADP-ribosyltransferase activity that conducts the majority of poly-ADP-ribosylation (PARylation). PARP1 is the most extensively studi...
Treatment of human cells with the anti-cancer drug cisplatin results in the caspase-dependent release of adduct-containing cell-free DNA [0.03%]
抗癌药物顺铂处理人细胞后释放出含有加合物的无细胞DNA是一个依赖半胱天冬酶的过程
Sri Meghana Yerrapragada,Aleena Alex,Sheera Adar et al.
Sri Meghana Yerrapragada et al.
Cell-free DNA (cfDNA) found in biofluids is increasingly being used in the diagnosis and treatment of a variety of disease states, including cancer. Though DNA is known to be susceptible to damage by many different chemotherapeutic compound...
Checkpoint activation and recovery: regulation of the 9-1-1 axis by the PP2A phosphatase [0.03%]
检查点激活和恢复：PP2A磷酸酶对9-1-1轴的调节作用
Erika Casari,Renata Tisi,Maria Pia Longhese
Erika Casari
Genome integrity is continuously monitored by elaborate cellular networks, collectively referred to as the DNA damage response (DDR), which detect DNA lesions and transmit the information to downstream targets, thereby coordinating a broad ...
DNA polymerase beta expression in head & neck cancer modulates the poly(ADP-ribose)-mediated replication checkpoint [0.03%]
DNA聚合酶β在头颈部肿瘤中通过调控多（ADP-核糖）介导的复制检点发挥功能
Md Maruf Khan,Wynand P Roos,Charlotte R Pearson et al.
Md Maruf Khan et al.
Head and Neck Squamous Cell Carcinoma (HNSCC) imposes a significant health burden, necessitating innovative therapeutic strategies to enhance treatment efficacy. Current treatments, such as surgery, radiation, and chemotherapy, have limited...
Dynamics of chromatin factors RSF1, CENPS and CENPX at DNA damage sites [0.03%]
染色质重塑因子RSF1、CENPS和CENPX在DNA损伤位点的动态变化
Pritishkumar Tidke,Andrew Flaus,Helen Dodson
Pritishkumar Tidke
Chromatin has a major influence on the DNA damage response (DDR). Several chromatin-related factors participate in specialised DNA packaging during the DDR including the CENPS and CENPX histone fold proteins, also known as MHF1/2, and the c...
Initiation of base excision repair is modulated by nucleosome occupancy modifying sequences [0.03%]
核小体占位修饰序列调节碱基切除修复的启动
Giovannia M Barbosa,Sarah Delaney
Giovannia M Barbosa
Nucleosome occupancy varies across the genome and plays a critical role in modulating DNA accessibility. While the effect of occupancy on gene expression has been studied, its influence on DNA repair, particularly base excision repair (BER)...
PARP1-PROTACs providing novel opportunities in precision oncology by targeting DNA damage response [0.03%]
靶向DNA损伤反应的PARP1-PROTACs在精准肿瘤学中提供新的机遇
Md Sadique Hussain,Gaurav Gupta
Md Sadique Hussain
Marlo K Thompson,Mark H Eggers,Danielle Flores et al.
Marlo K Thompson et al.
Nei endonuclease VIII-like 1 (NEIL1) is a bifunctional human DNA glycosylase that catalyzes the first step of the base excision repair (BER) pathway by recognizing and excising oxidized bases, including thymine glycol and the further oxidat...