Inhibition of both SWI/SNF ATPases by BRM014 impairs homologous recombination, sensitizes cells to DNA damage and PARP inhibitors, and activates the cGAS/STING response [0.03%]
BRM014通过抑制SWI/SNF ATP酶抑制同源重组，使细胞对DNA损伤和PARP抑制剂敏感并激活cGAS/STING反应
Peter Alfano,Federico Rocha,Andrew Dille et al.
Peter Alfano et al.
SWI/SNF chromatin remodelers hydrolyze ATP to modulate chromatin accessibility and are mutated in up to 20 % of human cancers. The development of ATPase inhibitors and proteolysis targeting chimeras (PROTACs) have shown that SWI/SNF complex...
Base excision repair in human cancer: Emerging diagnostic and therapeutic target [0.03%]
人类癌症中的碱基切除修复：正在兴起的诊断和治疗靶点
Wenli Zhou,Xinming Jing,Ruyi Hang et al.
Wenli Zhou et al.
DNA base excision repair (BER) is an evolutionarily conserved and essential DNA repair mechanism that acts as the major surveillance system for base lesions caused by endogenous and exogenous attacks. Therefore, BER is required for maintain...
The role of DNA repair deficiency in lipid accumulation: A proof-of-concept study [0.03%]
DNA修复缺陷在脂质积累中的作用：概念验证研究
Houan Tu,Ibbo Willems,Anastasiya Mircheva et al.
Houan Tu et al.
Animal models suggest an association between base excision repair (BER) deficiency and increased risk of obesity. To mechanistically investigate the effect of BER deficiency on intracellular lipid accumulation, we studied metabolic activity...
Corrigendum to "Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer" [DNA Repair 152 (2025) 103868] [0.03%]
"cGAS机制的研究进展：揭示DNA损伤和免疫感应在癌症中的作用的更正[DNA修复152（2025）103868]"
Min-Guk Cho,Gaorav P Gupta
Min-Guk Cho
Published Erratum
DNA repair. 2025 Aug 1:103878. DOI:10.1016/j.dnarep.2025.103878 2025
Cytosolic DNA and intracellular Ca2+: Maintaining genome stability during replication stress [0.03%]
细胞质DNA和胞内Ca2+：在复制压力下维持基因组稳定性
Shan Li,Hsiang-Ting Lu,Zhongsheng You
Shan Li
Maintaining genome stability during DNA replication is a critical cellular challenge. Various surveillance and repair mechanisms have evolved to cope with replication stress, which can be caused by environmental insults, metabolic byproduct...
DNA repair at the crossroads of tumor immunogenicity and cancer therapy: Harnessing innate and adaptive immune pathways for improved therapeutic outcomes [0.03%]
DNA修复在肿瘤免疫原性和癌症治疗的交汇点：利用先天和适应性免疫途径以改善治疗效果
Zhanfeng Liang,Yangrui Xu,Chuan-Yuan Li
Zhanfeng Liang
Immunotherapy has revolutionized cancer treatment, particularly with immune checkpoint inhibitors (ICIs), which harness the immune system to achieve durable antitumor responses. DNA repair pathways, essential for maintaining genomic stabili...
DNA damage response of U2OS cells to low doses of gamma radiation delivered at very low dose rate [0.03%]
U2OS细胞极低剂量率暴露于低剂量γ射线后的DNA损伤反应
Magdalena Płódowska,Wiktoria Krakowiak,Aneta Węgierek-Ciuk et al.
Magdalena Płódowska et al.
The DNA damage response (DDR) of cells to low dose and low dose rate ionizing radiation is weak and remains a matter of controversy. The response can be studied by exposing cells to a low adapting dose (AD) and, subsequently to a high chall...
The role of human PrimPol active site residue Gln48 in catalysis and complex formation with DNA [0.03%]
Gln48在人类PrimPol催化作用和与DNA复合物形成中的作用
Elizaveta O Boldinova,Alena V Makarova
Elizaveta O Boldinova
Human PrimPol is a primase-polymerase involved in the mechanism of DNA synthesis reinitiation at the sites of DNA damage and replication fork collapse. By using its DNA primase activity, PrimPol synthesizes DNA primers which can be utilized...
Using the safety scissors: DNA resection regulation at DNA double-strand breaks and telomeres [0.03%]
使用安全剪刀：DNA双链断裂和端粒处的DNA重结合作用调节机制
Michael M Soniat,Logan R Myler
Michael M Soniat
DNA resection is a universal process in genome maintenance by which one strand of DNA is degraded, leaving the other strand intact. This sometimes highly processive process is critical for many forms of DNA damage repair, replication-couple...
Raquel Ortega,Benjamin G Bitler,Nausica Arnoult
Raquel Ortega
Poly(ADP-ribose) polymerase 1 (PARP1) is one of the most abundant nuclear proteins in human cells and plays critical roles in numerous cellular processes, including the response to DNA damage. PARP1 is activated by and rapidly localizes to ...