From cooperation to conflicts - A complicated relationship between transcription and replication [0.03%]
从合作到冲突-转录与复制的复杂关系
Syed Shahid Musvi,Tatiana N Moiseeva
Syed Shahid Musvi
A tight coordination between transcription and DNA replication is essential to maintain genome stability. Both excessive transcription and upregulated initiation of DNA replication result in transcription replication conflicts and DNA damag...
Synthetic cytotoxicity profiling of cohesin mutants highlights recombination-based dependencies [0.03%]
合成的细胞毒性谱分析共hesin突变体强调了重组依赖性
Rafaela Horbach Marodin,Ecaterina Cozma,Sivan Reytan-Miron et al.
Rafaela Horbach Marodin et al.
Cohesin maintains genome integrity through its ability to bind and link DNA molecules via a Structural Maintenance of Chromatin (SMC) activity. These effects are manifested through its major function in sister chromatid cohesion, but also t...
Unveiling cGAS mechanisms: Insights into DNA damage and immune sensing in cancer [0.03%]
揭开cGAS的机制面纱：癌症中DNA损伤和免疫识别的新见解
Min-Guk Cho,Gaorav P Gupta
Min-Guk Cho
The innate immune sensing system plays a critical role in recognizing and responding to DNA damage, which is a key factor in cancer development and progression. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway...
Penny Jeggo,Bennett Van Houten
Penny Jeggo
DNA topoisomerase IIß inhibition blocks DNA end resection and synergizes with PARPi in BRCA1-deficient models [0.03%]
DNA拓扑异构酶IIβ抑制可阻断DNA末端外切加工 并且能够与BRCA1缺陷模型中的PARP抑制剂协同作用
Rosa Camarillo,Rosario Prados-Carvajal,Andrés Cruz-García et al.
Rosa Camarillo et al.
DNA end resection is a critical step that governs how a broken chromosome will be repaired. As such, it is heavily regulated by multiple cellular signals and processes. Alterations in the regulation of DNA end resection have consequences fo...
FBH1 and the replication stress response: Implications for genome stability and cancer development [0.03%]
FBH1与复制压力反应：基因组稳定性和癌症发生的意义
Joshua L Turner,Jennifer M Mason
Joshua L Turner
The replication stress response plays important roles in maintaining genome stability.In this review article, we focus on the role of FBH1 in the replication stress response and promoting death in cells with excessive DNA damage. FBH1-defic...
PARPs and ADP-ribosyl hydrolases in cancer therapy: From drug targets to biomarkers [0.03%]
聚ADP核糖聚合酶和腺苷二磷酸核糖水解酶在癌症治疗中的作用：从药物靶点到生物标志物
Joséphine Groslambert,Kira Schützenhofer,Luca Palazzo et al.
Joséphine Groslambert et al.
The PARP family of enzymes catalyzes ADP-ribosylation, a modification of macromolecules, and plays a crucial role in DNA damage repair. The landmark discovery that cancer cells deficient in homologous recombination repair are highly sensiti...
Proofreading of mismatches within primer-template junctions by Escherichia coli DNA polymerase I in vitro and in vivo [0.03%]
大肠杆菌DNA聚合酶I在体内和体外通过模板转换对引物-模板交界处错配的校正作用
Hui-Lan Chang,Kang-Yi Su,Steven D Goodman et al.
Hui-Lan Chang et al.
Escherichia coli DNA polymerase I (Pol I) possesses a 3' to 5' proofreading function. Using a non-inhibitory in vitro proofreading assay and MALDI-TOF MS analysis, we demonstrated the Pol I proofreading function was effective at removal of ...
Altered pathways in Cockayne syndrome: Involvement of MAPK, PI3K-Akt, extracellular matrix, inflammation, and neuronal signaling [0.03%]
科克恩综合征的异常途径：MAPK、PI3K-Akt、细胞外基质、炎症和神经信号转导的参与
Gustavo Satoru Kajitani,Marina Andrade Tomaz,Giovana da Silva Leandro et al.
Gustavo Satoru Kajitani et al.
Cockayne syndrome (CS) is a disorder characterized by neurodegeneration and a segmental progeroid phenotype, resulting from mutations in ERCC8/CSA or ERCC6/CSB genes. These genes encode proteins essential for the DNA repair pathway known as...
DNA damage response and genomic instability disorder: Meeting report of the 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th international symposium on DNA damage response & human disease (isDDRHD-2024) [0.03%]
DNA损伤反应与基因组不稳定障碍：第二届阿佩特希亚-毛细血管扩张性共济失调研讨会(ATW-2024)暨第十五届国际DNA损伤反应及人类疾病研讨会(isDDRHD-2024)会议报告
Yisui Xia,Zhao-Qi Wang,Xingzhi Xu
Yisui Xia
The 20th Ataxia-Telangiectasia Workshop (ATW-2024) in conjunction with the 15th International Symposium on DNA Damage Response & Human Disease (isDDRHD-2024) was held in Shenzhen, China, on October 17-20th, 2024. Organized by Xingzhi Xu, Zh...