Overcoming natural replication barriers formed by DNA structures and the role of repositioning to the nuclear periphery [0.03%]
克服由DNA结构形成的自然复制障碍及其重新定位到核周区的作用
Jan Leendert Boer,Tyler M Maclay,Nolan T Caile et al.
Jan Leendert Boer et al.
Endogenous barriers to DNA replication, such as repetitive DNA, non-B DNA structures, and protein barriers present significant challenges to replication. Upon encountering one of these barriers, cells employ a number of strategies to ensure...
Abigayle F Vito,Daniel J Boesch,Ava M Hammons et al.
Abigayle F Vito et al.
Base excision repair (BER) is a genome surveillance pathway responsible for repairing DNA base lesions distributed throughout the chromatinized eukaryotic genome. However, chromatin structure acts as a dynamic structural barrier that restri...
Lets talk about ataxia-telangiectasia: Meeting report of the AT clinical research conference June 2025 [0.03%]
论儿童共济失调毛细血管扩张症：2025年6月AT临床研究会议报告
David Coman,Penny Jeggo,Martin Lavin
David Coman
Almost fifty years after the identification of ataxia telangiectasia (A-T) as a radiosensitive disorder and thirty years following the identification of ataxia telangiectasia mutated (ATM) as the defective gene, clinicians and scientists ga...
Yiyan Zhang,Jiyuan Teng,Xiaolong Chen et al.
Yiyan Zhang et al.
DNA damage response (DDR) is a complex network of biological pathways, maintaining eukaryotic genetic stability and frequently altered in cancer cells. Aberrant DDR regulation could be a double-edge sword in cancer: DDR defects could lead t...
Modulation of OGG1 enzymatic activity by the cellular machinery - have all the boxes been ticked? [0.03%]
调控OGG1酶活性的细胞机制-所有问题都解决了吗？
Alice Eddershaw,Natálie Rudolfová,Holly Dawson et al.
Alice Eddershaw et al.
8-oxoguanine DNA glycosylase 1 (OGG1) is the key enzyme responsible for identifying and removing 8-oxoguanine (8-oxoG), the most common oxidative lesion in DNA. While its central role in base excision repair (BER) is well established, OGG1 ...
Joshua L Turner,Georgia Moore,Tyler J McCraw et al.
Joshua L Turner et al.
Homologous recombination proteins maintain genome stability by repairing double strand breaks and protecting replication fork stability. Defects in homologous recombination results in cancer predisposition but can be exploited due to increa...
UBE2C promotes cell cycle progression and suppresses DNA damage-induced apoptosis in triple-negative breast cancer [0.03%]
UBE2C促进三阴性乳腺癌细胞周期进程并抑制DNA损伤诱导的凋亡
Qin Hu,Kewu Wang,Chuanrong Chen et al.
Qin Hu et al.
Background: Triple-negative breast cancer (TNBC), characterized by its aggressiveness, constitutes a unique breast cancer subtype, lacking effective targeted therapies. Its progression is often driven by cell cycle contro...
CPD photolyase evolution supports amphibian UV-sensitivity hypothesis [0.03%]
CP修复酶的进化支持两栖动物对紫外线敏感的假说
James Eduardo Lago Londero,Rayana Dos Santos Feltrin,Ana Lucia Anversa Segatto et al.
James Eduardo Lago Londero et al.
The UV-sensitivity hypothesis for amphibian decline proposes that interspecific variation in cyclobutane pyrimidine dimer (CPD) photolyase activity determines species' UV sensitivity, which is linked to their natural history and population ...
PARP enzyme synthesis of protein-free poly(ADP-ribose): Implications for DNA damage signaling and repair [0.03%]
无蛋白poly(ADP-核糖)的PARP酶合成：对DNA损伤信号转导及修复的意义
Marie-France Langelier,John M Pascal
Marie-France Langelier
Poly(ADP-ribose) or PAR is a versatile signaling molecule with a broad impact on human biology. PAR is a prominent indicator of cellular DNA damage and genomic transactions such as replication and transcription. Canonically, human PARP enzy...
The comet assay: A contemporary approach for detecting genomic instability [0.03%]
彗星实验：检测基因组不稳定性的现代方法
Xingkai He,Feng Chen,Linmin Zhou et al.
Xingkai He et al.
The comet assay has evolved into a high-resolution, multifunctional technique for evaluating DNA damage, repair capacity, and epigenetic modifications. Over the past fifteen years, significant advancements-including the enzyme-modified come...