Contributions of DNA double strand break repair pathways to DNA crosslink repair [0.03%]
DNA交联修复中双链断裂修复途径的作用
Gerarda van de Kamp,Israel Tojal da Silva,Sander Barnhoorn et al.
Gerarda van de Kamp et al.
DNA crosslink-inducing drugs are widely used in clinical settings for treatment of solid tumors. Double strand breaks (DSBs) that arise during interstrand crosslink (ICL) repair are crucial determinants of the therapeutic response, as they ...
Maria Berruezo-Llacuna,Eleni Kabrani,Michela Di Virgilio
Maria Berruezo-Llacuna
The ability of B lymphocytes to diversify immunoglobulin (Ig) genes is central to the generation of high-affinity, class-switched antibodies and the establishment of effective humoral immunity. This diversification is achieved through three...
DNA damage response inhibitors in cancer therapy: Mechanisms, clinical development, and combination strategies [0.03%]
DNA损伤反应抑制剂在癌症治疗中的作用：机制、临床开发及联合策略
Seon-Gyeong Lee,Jinwoo Kim,Euihwan Jeong et al.
Seon-Gyeong Lee et al.
Impaired genomic stability is a hallmark of many cancers, with the DNA damage response (DDR) mechanisms serving as critical safeguards for maintaining genomic integrity. These intricate DDR networks, encompassing various DNA repair and dama...
Soonjoung Kim,Hasan F Alnaser,Scott Keeney et al.
Soonjoung Kim et al.
Meiosis generates reproductive cells with a reduced genome complement, with most species using homologous recombination to promote accurate meiotic chromosome segregation and to generate genetic diversity among offspring. A critical step in...
Proofreading exonuclease activities of Polδ and Polε differentially contribute to the removal of chain-terminating nucleoside analogs [0.03%]
证明外切核酸酶活性对聚合酶δ和聚合酶ε去除链终止核苷类似物的不同贡献
Eri Nishizawa,Hiromori Ohkubo,Ryotaro Kawasumi et al.
Eri Nishizawa et al.
Chain-terminating nucleoside analogs (CTNAs) are incorporated into genome during replication by replicative polymerase delta (Polδ) and epsilon (Polε), then inhibit DNA synthesis by preventing subsequent polymerization. The proofreading e...
Xiyuan Zheng,Xinying Wu,Lei Wang et al.
Xiyuan Zheng et al.
S-palmitoylation is a dynamic post-translational lipid modification that regulates key cellular processes. It is mediated by aspartate-histidine-histidine-cysteine-family palmitoyltransferases (PATs) and reversed by acyl-protein thioesteras...
The model moss Physcomitrium patens relies heavily on homologous recombination to repair DNA double-strand breaks [0.03%]
轮藻模式植物扁萼苔主要利用同源重组修复DNA双链断裂
Ayako N Sakamoto,Yuichiro Yokota,Pierre-François Perroud et al.
Ayako N Sakamoto et al.
We previously showed that moss (Physcomitrium patens) cells are highly radioresistant and suggested that P. patens uses an efficient mechanism to repair DNA double-strand breaks (DSBs). Homologous recombination (HR), canonical non-homologou...
Toxoplasma gondii RAD51 recombinase is required to overcome DNA replication stress and its inactivation leads to bradyzoite differentiation [0.03%]
托拉川伯氏疟原虫RAD51重组酶能克服DNA复制应激及其失活导致速子体向缓殖子的分化
Ana M Saldarriaga Cartagena,Ayelén Aparicio Arias,Constanza Cristaldi et al.
Ana M Saldarriaga Cartagena et al.
Toxoplasma gondii is an obligate intracellular parasite with a high replication rate that can lead to DNA replicative stress, in turn associated with the generation of DNA double-strand breaks (DSBs). Cells have two main pathways to repair ...
Inhibition of both SWI/SNF ATPases by BRM014 impairs homologous recombination, sensitizes cells to DNA damage and PARP inhibitors, and activates the cGAS/STING response [0.03%]
BRM014通过抑制SWI/SNF ATP酶抑制同源重组，使细胞对DNA损伤和PARP抑制剂敏感并激活cGAS/STING反应
Peter Alfano,Federico Rocha,Andrew Dille et al.
Peter Alfano et al.
SWI/SNF chromatin remodelers hydrolyze ATP to modulate chromatin accessibility and are mutated in up to 20 % of human cancers. The development of ATPase inhibitors and proteolysis targeting chimeras (PROTACs) have shown that SWI/SNF complex...
Base excision repair in human cancer: Emerging diagnostic and therapeutic target [0.03%]
人类癌症中的碱基切除修复：正在兴起的诊断和治疗靶点
Wenli Zhou,Xinming Jing,Ruyi Hang et al.
Wenli Zhou et al.
DNA base excision repair (BER) is an evolutionarily conserved and essential DNA repair mechanism that acts as the major surveillance system for base lesions caused by endogenous and exogenous attacks. Therefore, BER is required for maintain...