Identification of a prototypical single-stranded uracil DNA glycosylase from Listeria innocua [0.03%]
嗜乳链球菌单链尿嘧啶DNA糖基化酶基因的克隆、表达及初步功能分析
Jing Li,Ye Yang,Jose Guevara et al.
Jing Li et al.
A recent phylogenetic study on UDG superfamily estimated a new clade of family 3 enzymes (SMUG1-like), which shares a lower homology with canonic SMUG1 enzymes. The enzymatic properties of the newly found putative DNA glycosylase are unknow...
EXO1 suppresses double-strand break induced homologous recombination between diverged sequences in mammalian cells [0.03%]
EXO1抑制哺乳动物细胞中双链断裂诱导的分歧序列间的同源重组
Chun-Chin Chen,Elena Avdievich,Yongwei Zhang et al.
Chun-Chin Chen et al.
DNA double-strand breaks (DSBs) can be repaired through several mechanisms, including homologous recombination (HR). While HR between identical sequences is robust in mammalian cells, HR between diverged sequences is suppressed by DNA misma...
Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes [0.03%]
人类细胞含有一种因子，可促进DNA糖基化酶介导的染色质中封闭位点上氧化碱基的切除修复
R L Maher,C G Marsden,A M Averill et al.
R L Maher et al.
Reactive oxygen species generate some 20,000 base lesions per human cell per day. The vast majority of these potentially mutagenic or cytotoxic lesions are subject to base excision repair (BER). Although chromatin remodelers have been shown...
Philip C Hanawalt,Samuel H Wilson
Philip C Hanawalt
Mandira Manandhar,Megan G Lowery,Karen S Boulware et al.
Mandira Manandhar et al.
Nucleotide excision repair (NER) in mammalian cells requires the xeroderma pigmentosum group A protein (XPA) as a core factor. Remarkably, XPA and other NER proteins have been detected by chromatin immunoprecipitation at some active promote...
Differential effect of the overexpression of Rad2/XPG family endonucleases on genome integrity in yeast and human cells [0.03%]
Rad2/XPG 家族内切酶过表达在酵母和人类细胞中对基因组完整性影响的差异性研究
Sonia Jimeno,Emilia Herrera-Moyano,Pedro Ortega et al.
Sonia Jimeno et al.
Eukaryotic cells possess several DNA endonucleases that are necessary to complete different steps in DNA metabolism. Rad2/XPG and Rad27/FEN1 belong to a group of evolutionary conserved proteins that constitute the Rad2 family. Given the imp...
Close encounters: Moving along bumps, breaks, and bubbles on expanded trinucleotide tracts [0.03%]
近距离接触：在扩增的三核苷酸踪迹的突起、断裂和气泡上移动
Aris A Polyzos,Cynthia T McMurray
Aris A Polyzos
Expansion of simple triplet repeats (TNR) underlies more than 30 severe degenerative diseases. There is a good understanding of the major pathways generating an expansion, and the associated polymerases that operate during gap filling synth...
Nucleolytic degradation of 3'-ending overhangs is essential for DNA-end resection in RecA-loading deficient recB mutants of Escherichia coli [0.03%]
核酶降解3'-端突出序列对RecA装载缺陷型大肠杆菌recB突变体末端切除修复是必需的
Siniša Ivanković,Dušica Vujaklija,Damir Đermić
Siniša Ivanković
Degradation of a 5'-ending strand is the hallmark of the universal process of DNA double strand break (DSB) resection, which results in creation of the central recombination intermediate, a 3'-ending overhang. Here we show that in Escherich...
Deletion of RDINK4/ARF enhancer: A novel mutation to "inactivate" the INK4-ARF locus [0.03%]
INK4-ARF位点新的“失活”突变：RDINK4/ARF增强子的丢失
Ming J Poi,Thomas J Knobloch,Junan Li
Ming J Poi
The presence of an enhancer element, RDINK4/ARF (RD), in the prominent INK4-ARF locus provides a novel en bloc mechanism to simultaneously regulate the transcription of the p15INK4B (p15), p16INK4A (p16), and p14ARF tumor suppressor genes. ...
Replicative DNA polymerase defects in human cancers: Consequences, mechanisms, and implications for therapy [0.03%]
人类癌症中的复制型DNA聚合酶缺陷：后果、机制及治疗意义
Stephanie R Barbari,Polina V Shcherbakova
Stephanie R Barbari
The fidelity of DNA replication relies on three error avoidance mechanisms acting in series: nucleotide selectivity of replicative DNA polymerases, exonucleolytic proofreading, and post-replicative DNA mismatch repair (MMR). MMR defects are...