Transcription coupled repair deficiency protects against human mutagenesis and carcinogenesis: Personal Reflections on the 50th anniversary of the discovery of xeroderma pigmentosum [0.03%]
转录耦联修复缺陷保护人类基因突变和致癌作用——纪念着色性干皮病发现50周年个人感言
James E Cleaver
James E Cleaver
Xeroderma pigmentosum (XP) patients who lack the main damage recognition protein for global genome repair (GGR), XPC, have greatly increased skin cancer rates and elevated mutation frequencies originating from unrepaired ultraviolet photopr...
Role of the DNA repair glycosylase OGG1 in the activation of murine splenocytes [0.03%]
DNA修复甘油酶OGG1在小鼠脾细胞活化中的作用
Marco Seifermann,Alexander Ulges,Tobias Bopp et al.
Marco Seifermann et al.
OGG1 (8-oxoguanine-DNA glycosylase) is the major DNA repair glycosylase removing the premutagenic DNA base modification 8-oxo-7,8-dihydroguanine (8-oxoG) from the genome of mammalian cells. In addition, there is accumulating evidence that O...
Corrigendum to "The conserved Fanconi anemia nuclease Fan1 and the SUMO E3 ligase Pli1 act in two novel Pso2-independent pathways of DNA interstrand crosslink repair in yeast" [DNA Repair 12 (December (12)) (2013) 1011-1023] [0.03%]
“保守的法可尼贫血核酸内切酶Fan1和SUMO E3连接酶Pli1在酵母两个新的DNA交联修复途径中发挥作用”一文的勘误公告
Y Fontebasso,T J Etheridge,A W Oliver et al.
Y Fontebasso et al.
Published Erratum
DNA repair. 2014 Dec:24:150. DOI:10.1016/j.dnarep.2014.11.003 2014
Valproic acid sensitizes breast cancer cells to hydroxyurea through inhibiting RPA2 hyperphosphorylation-mediated DNA repair pathway [0.03%]
丙戊酸通过抑制RPA2高磷酸化介导的DNA修复途径使乳腺癌细胞对羟基脲敏感
Youjia Tian,Guochao Liu,Hui Wang et al.
Youjia Tian et al.
It was reported that valproic acid (VPA, a histone deacetylase inhibitor) can sensitize cancer cells to hydroxyurea (HU, a ribonucleotide reductase inhibitor) for chemotherapy, although the mechanism of VPA-induced HU sensitization is uncle...
Polyphosphate is a key factor for cell survival after DNA damage in eukaryotic cells [0.03%]
聚磷酸盐是真核细胞DNA损伤后存活的关键因素
Samuel Bru,Bàrbara Samper-Martín,Eva Quandt et al.
Samuel Bru et al.
Cells require extra amounts of dNTPs to repair DNA after damage. Polyphosphate (polyP) is an evolutionary conserved linear polymer of up to several hundred inorganic phosphate (Pi) residues that is involved in many functions, including Pi s...
Molecular basis for the functions of a bacterial MutS2 in DNA repair and recombination [0.03%]
细菌MutS2在DNA修复和重组中的分子作用机制研究
Ge Wang,Robert J Maier
Ge Wang
Bacterial MutS2 proteins, consisting of functional domains for ATPase, DNA-binding, and nuclease activities, play roles in DNA recombination and repair. Here we observe a mechanism for generating MutS2 expression diversity in the human path...
Stimulation of RNA Polymerase II ubiquitination and degradation by yeast mRNA 3'-end processing factors is a conserved DNA damage response in eukaryotes [0.03%]
真菌mRNA 3'端加工因子通过泛素化降解刺激RNA聚合酶II是真核生物中一种保守的DNA损伤反应
Jason N Kuehner,James W Kaufman,Claire Moore
Jason N Kuehner
The quality and retrieval of genetic information is imperative to the survival and reproduction of all living cells. Ultraviolet (UV) light induces lesions that obstruct DNA access during transcription, replication, and repair. Failure to r...
The C. elegans SET-2/SET1 histone H3 Lys4 (H3K4) methyltransferase preserves genome stability in the germline [0.03%]
秀丽隐杆线虫的SET-2/SET1组蛋白H3-Lys4甲基化酶在线粒体遗传中保护种系基因稳定性
M Herbette,M G Mercier,F Michal et al.
M Herbette et al.
Maintaining the integrity of genetic information across generations is essential for both cell survival and reproduction, and requires the timely repair of DNA damage. Histone-modifying enzymes play a central role in the DNA repair process ...
Synthetic lethality between murine DNA repair factors XLF and DNA-PKcs is rescued by inactivation of Ku70 [0.03%]
DNA修复因子XLF和DNA-PKcs之间的合成致死性可通过灭活Ku70得到缓解
Mengtan Xing,Magnar Bjørås,Jeremy A Daniel et al.
Mengtan Xing et al.
DNA double-strand breaks (DSBs) are recognized and repaired by the Classical Non-Homologous End-Joining (C-NHEJ) and Homologous Recombination pathways. C-NHEJ includes the core Ku70 and Ku80 (or Ku86) heterodimer that binds DSBs and thus pr...
DNA binding and unwinding by Hel308 helicase requires dual functions of a winged helix domain [0.03%]
Hel308解旋酶的DNA结合和解旋作用需要带翼螺旋结构域的双功能参与
Sarah J Northall,Ryan Buckley,Nathan Jones et al.
Sarah J Northall et al.
Hel308 helicases promote genome stability linked to DNA replication in archaea, and have homologues in metazoans. In the crystal structure of archaeal Hel308 bound to a tailed DNA duplex, core helicase domains encircle single-stranded DNA (...