Evolutionary dynamics and significance of multiple subclonal mutations in cancer [0.03%]
癌症多重亚克隆突变的进化动力学及意义
Robert A Beckman,Lawrence A Loeb
Robert A Beckman
For the last 40 years the authors have collaborated on trying to understand the complexities of human cancer by formulating testable mathematical models that are based on mutation accumulation in human malignancies. We summarize the concept...
Error-prone bypass of O6-methylguanine by DNA polymerase of Pseudomonas aeruginosa phage PaP1 [0.03%]
铜绿假单胞病毒PaP1的DNA聚合酶易错绕过O6-甲基鸟嘌呤
Shiling Gu,Jingyuan Xiong,Ying Shi et al.
Shiling Gu et al.
O6-Methylguanine (O6-MeG) is highly mutagenic and is commonly found in DNA exposed to methylating agents, generally leads to G:C to A:T mutagenesis. To study DNA replication encountering O6-MeG by the DNA polymerase (gp90) of P. aeruginosa ...
ASCIZ/ATMIN is dispensable for ATM signaling in response to replication stress [0.03%]
ASCIZ/ATMIN在复制压力下激活ATM信号通路方面可有可无
Rui Liu,Ashleigh King,Nicolas C Hoch et al.
Rui Liu et al.
The ATM kinase plays critical roles in the response to DNA double-strand breaks, and can also be activated by prolonged DNA replication blocks. It has recently been proposed that replication stress-dependent ATM activation is mediated by AS...
Susan T Lovett
Susan T Lovett
Replication forks frequently are challenged by lesions on the DNA template, replication-impeding DNA secondary structures, tightly bound proteins or nucleotide pool imbalance. Studies in bacteria have suggested that under these circumstance...
Nayun Kim,Sue Jinks-Robertson
Nayun Kim
Topoisomerases manage the torsional stress associated with the separation of DNA strands during transcription and DNA replication. Eukaryotic Topoisomerase I (Top1) is a Type IB enzyme that nicks and rejoins only one strand of duplex DNA, a...
Role of recombination and replication fork restart in repeat instability [0.03%]
重组和复制叉重启在重复序列不稳定性中的作用
Erica J Polleys,Nealia C M House,Catherine H Freudenreich
Erica J Polleys
Eukaryotic genomes contain many repetitive DNA sequences that exhibit size instability. Some repeat elements have the added complication of being able to form secondary structures, such as hairpin loops, slipped DNA, triplex DNA or G-quadru...
Dormant origins as a built-in safeguard in eukaryotic DNA replication against genome instability and disease development [0.03%]
休眠起源作为真核生物DNA复制的内置保护机制防止基因组不稳定和疾病发生
Naoko Shima,Kayla D Pederson
Naoko Shima
DNA replication is a prerequisite for cell proliferation, yet it can be increasingly challenging for a eukaryotic cell to faithfully duplicate its genome as its size and complexity expands. Dormant origins now emerge as a key component for ...
DNA requirements for interaction of the C-terminal region of Ku80 with the DNA-dependent protein kinase catalytic subunit (DNA-PKcs) [0.03%]
DNA-PKcs与Ku80蛋白C末端相互作用的DNA要求条件
Sarvan Kumar Radhakrishnan,Susan P Lees-Miller
Sarvan Kumar Radhakrishnan
Non-homologous end joining (NHEJ) is the major pathway for the repair of ionizing radiation induced DNA double strand breaks (DSBs) in human cells. Critical to NHEJ is the DNA-dependent interaction of the Ku70/80 heterodimer with the DNA-de...
Bibhusita Pani,Evgeny Nudler
Bibhusita Pani
Transcription-coupled DNA repair (TCR) acts on lesions in the transcribed strand of active genes. Helix distorting adducts and other forms of DNA damage often interfere with the progression of the transcription apparatus. Prolonged stalling...
Unveiling the non-repair face of the Base Excision Repair pathway in RNA processing: A missing link between DNA repair and gene expression? [0.03%]
揭开基于修复途径在RNA处理中的非修复面孔：DNA修复与基因表达之间的缺失环节？
Giulia Antoniali,Matilde Clarissa Malfatti,Gianluca Tell
Giulia Antoniali
The Base Excision Repair (BER) pathway, initially studied as a mere DNA repair pathway, has been later found to be implicated in the expression of cancer related genes in human. For several years, this intricate involvement in apparently di...