Advances in diagnostic and therapeutic applications of mismatch repair loss in cancer [0.03%]
错配修复在癌症诊疗中的应用进展
J T DeWitt,D Jimenez-Tovar,A Mazumder et al.
J T DeWitt et al.
Mismatch repair (MMR) is a highly conserved, fundamental DNA damage repair pathway that maintains genomic fidelity during cell replication. MMR dysregulation contributes to tumor formation by promoting genomic instability thereby increasing...
Anna V Yudkina,Dmitry O Zharkov
Anna V Yudkina
Abasic, or apurinic/apyrimidinic sites (AP sites) are among the most abundant DNA lesions, appearing in DNA both through spontaneous base loss and as intermediates of base excision DNA repair. Natural aldehydic AP sites have been known for ...
Peng Li,Duo Wu,Xiaochun Yu
Peng Li
Poly(ADP-ribosyl)ation (PARylation), a reversible post-translational modification mediated by poly(ADP-ribose) polymerases (PARPs), plays crucial roles in DNA replication and DNA damage repair. Since interfering PARylation induces selective...
Mustapha Olatunji,Yuan Liu
Mustapha Olatunji
Endogenous and environmental stressors can damage DNA and RNA to compromise genome and transcriptome stability and integrity in cells, leading to genetic instability and diseases. Recent studies have demonstrated that RNA damage can also mo...
The effect of methylation and hydroxymethylation of cytosine on activity and fidelity of Pol λ and Pol β [0.03%]
胞嘧啶的甲基化和水羟甲基化对Pol λ和Pol β的活性及保真度的影响
Evgeniy S Shilkin,Daria V Petrova,Alexander A Kruchinin et al.
Evgeniy S Shilkin et al.
Сytosine methylation in CpG dinucleotides is the most common epigenetic mark in human cells. Under active demethylation process 5-methylcytosine (mC) can be converted to 5-hydroxymethylcytosine (hmC). Cytosine methylation increases the ris...
Amanda K McCullough,Irina G Minko,Michael M Luzadder et al.
Amanda K McCullough et al.
Phylogenetic analyses of DNA glycosylases that function in the initiation step of base excision repair reveal a high degree of conservation within the genes encoding Nei-like DNA glycosylase 1 (NEIL1). In concert with other glycosylases, th...
Pathological modulation of genome maintenance by cancer/testes antigens (CTAs) [0.03%]
癌症/睾丸抗原(CTA)对基因组维持的病理调节作用
Cyrus Vaziri,Karly Forker,Xingyuan Zhang et al.
Cyrus Vaziri et al.
The Cancer Testis Antigens (CTAs) are a group of germ cell proteins that are absent from normal somatic cells yet aberrantly expressed in many cancer cells. When mis-expressed in cancer cells, many CTAs promote tumorigenic characteristics i...
Bennett Van Houten,Wim Vermeulen
Bennett Van Houten
To divide or not to divide? NAC8 (SOG1) as a key regulator of DNA damage response in barley (Hordeum vulgare L.) [0.03%]
分与不分？NAC8（SOG1）作为大麦（Hordeum vulgare L.）DNA损伤响应的关键调控因子
Miriam Szurman-Zubrzycka,Anna Kocjan,Emilia Spałek et al.
Miriam Szurman-Zubrzycka et al.
We identified several new TILLING mutants of barley (Hordeum vulgare L.) with missense mutations in the HvNAC8 gene, a homolog of the SUPPRESSOR OF GAMMA RESPONSE 1 (SOG1) gene in Arabidopsis thaliana. In Arabidopsis, SOG1 is the primary re...
Active genome integrity [0.03%]
活跃的基因组完整性
Sukesh R Bhaumik
Sukesh R Bhaumik