Integration of hydrogel forming microneedles with polyethylene glycol reservoir assisted clindamycin dermal delivery [0.03%]
基于聚乙二醇药库的克林霉素储库型凝胶贴剂及凝胶形成微针透皮给药系统研究
Dewi Purwaningsih,Christopher Kosasi,Nun Salsabila Maddeppungeng et al.
Dewi Purwaningsih et al.
Diabetic ulcers (DU), commonly caused by impaired circulation and bacterial infection, remain a leading source of morbidity and mortality in patients with diabetes mellitus worldwide. Clindamycin (CLD) is recommended for mild to moderate DU...
Sodium alginate, corn starch, and herbal medicines: potential blend to stimulate the tissue regeneration [0.03%]
海藻酸钠、玉米淀粉和中草药：促进组织再生的潜在成分组合
Carina M da Silva,Rui L Reis,Vitor M Correlo et al.
Carina M da Silva et al.
Considering that the use of polysaccharides has been addressed in the replacement of tissue regeneration, the present work aimed to develop membranes made of sodium alginate, corn starch, and herbal medicines, with potential application of ...
Localized and sustained release of Puerarin from a calcium phosphate hydrogel enhances immunomodulatory bone repair by modulating pro-healing macrophage phenotype transitions [0.03%]
钙磷酸盐水凝胶局部递送可持续释放的富集异质核糖核酸蛋白p蛋白异构体以增强免疫调节骨修复并调控促愈合型巨噬细胞表型转换
Huasheng Xu,Kaile Wu,Fu Xu et al.
Huasheng Xu et al.
Manipulating the immune microenvironment is crucial for bone repair, with macrophages serving as key regulators. Their polarization state significantly influences bone healing. In this study, we examined the immunoregulatory effects of Puer...
Development of reduced graphene oxide-incorporated gelatin-polymannose hydrogel scaffolds as a 3D cell culture model for cancer research [0.03%]
用于癌症研究的3D细胞培养模型的还原氧化石墨烯-明胶-聚甘露糖海绵支架的开发
Hema Priya Manivannan,Vishnu Priya Veeraraghavan,Arul Prakash Francis
Hema Priya Manivannan
In this study, we have created a 3D environment conducive to A549 cell growth by developing a novel gelatin-polymannose scaffold incorporated with reduced graphene oxide (Gel:OPM:rGO). The Gel:OPM:rGO scaffold was fabricated and characteris...
In-situ forming alginate dialdehyde-gelatin hydrogel for sustained silver sulfadiazine delivery: in-vivo evaluation in a preclinical burn wound model [0.03%]
一种用于持续释放磺胺嘧啶银的就地成型藻酸 dialdehyde-胶原水凝胶：临床前烧伤模型中的体内评价
Geeta Patel,Gayatri Patel,Dhaval Patel
Geeta Patel
This study aimed to develop and optimize an in situ forming alginate dialdehyde (ADA)-gelatin hydrogel for sustained topical delivery of silver sulfadiazine (SSD) and to evaluate its burn wound healing efficacy in a preclinical rat model. A...
Glucose-responsive polymeric vesicles for insulin delivery in diabetic patients [0.03%]
用于糖尿病患者的葡萄糖响应型聚合物囊泡胰岛素递送系统
Pradip Kumar Yadav,Malay K Das,Taison Jamatia et al.
Pradip Kumar Yadav et al.
Irregular insulin secretion ultimately results in high blood glucose levels, leading to diabetes. Several oral hypoglycemic drugs and insulins have been discovered to control hyperglycemic conditions, which have a major risk factor for hypo...
Preparation, optimization and in vitro activity analysis of PVA/gelatin/sodium alginate-based (PGS) hydrogels loaded with Gardeniae Fructus Preparatus (JZZ) extract [0.03%]
基于PVA/明胶/海藻酸钠(PGS)水凝胶载番石榴果提取物(JZZ)的制备、优化及体外活性分析
Chenhao Liu,Chuchu Shan,Zebin Yu et al.
Chenhao Liu et al.
In this study, polyvinyl alcohol (PVA) was introduced into the traditional gelatin (Gel)/sodium alginate (SA) system, and PVA/Gel/SA hydrogels (PGS) were prepared by freeze-thaw cycling and Cu2+ crosslinking. After screening, proper PVA/Gel...
Coaxial electrospun PCL/PVA core-shell nanofibrous scaffolds with green-synthesized AgNPs for release-regulated antibacterial activity [0.03%]
绿色合成的银纳米颗粒同轴静电纺丝PCL / PVA核壳纳米纤维支架用于调节抗菌性能
Amanullah,Mainul Islam,Md Mustafizur Rahman et al.
Amanullah et al.
This study developed coaxially electrospun polycaprolactone/polyvinyl alcohol (PCL/PVA) core-shell nanofibrous scaffolds incorporating green-synthesized silver nanoparticles (AgNPs) from Synedrella nodiflora as candidate antibacterial wound...
Wei Zhou,Jinhang Jiang,Yong-Chang Yao et al.
Wei Zhou et al.
Articular cartilage (AC) possesses complex depth-dependent gradients in cell phenotype, matrix composition, metabolism, mechanics, and growth factors. These natural gradients are essential for cartilage function. Because of lack of blood ve...
Nanogels as smart delivery systems for bioactive compounds in bone regeneration: a review [0.03%]
纳米凝胶作为骨再生中生物活性化合物的智能递送系统：综述
Saranya Srinivasan,Ashwathi Vijayalekha,Suresh Kumar Anandasadagopan et al.
Saranya Srinivasan et al.
Bone regeneration remains a critical challenge in tissue engineering and requires innovative strategies to promote the efficient healing and restoration of bone function. Nanogels have emerged as promising carriers for bioactive compounds i...