Integrated GC-MS phytochemical analysis and in vivo assessment of antiarthritic activity of Curcuma zedoaria extracts [0.03%]
具有抗关节炎活性的姜黄根茎提取物的综合GC-MS植化分析及体内评价
Yusra Wasti,Syeda Aroosa Mohsin,Muhammad Tahir Aqeel et al.
Yusra Wasti et al.
Targeting oxidative stress and neurodegeneration: the role of Putranjiva roxburghii in Alzheimer's [0.03%]
靶向氧化应激和神经退行性病变：Roxburgh多蕊木在阿尔茨海默病中的作用
Vashu Bhardwaj,Falguni Goel,Mithun Singh Rajput
Vashu Bhardwaj
AD is a complex neurodegenerative disease that leads to progressive memory loss, worsening cognitive abilities, and synaptic dysfunction. The pathophysiology of the disease is driven by oxidative stress and neuroinflammation, which cause ne...
Pharmacological effects of cardamonin in metabolic diseases: a review on preclinical studies [0.03%]
卡莫adin药理作用在代谢性疾病中的研究进展：临床前研究综述
Aizhi Zhang,AbdulRahman Muthanna,Yu Zhao Lee et al.
Aizhi Zhang et al.
Interplay of oxidative stress and neuroinflammation in alzheimer's: insights into age-driven pathogenesis [0.03%]
氧化应激与阿尔茨海默病中神经炎症的相互作用：衰老驱动型疾病的发病机制启示
Sayed Mohammad Firdous,Shibam Chakrabortty,Vaishali R Undale et al.
Sayed Mohammad Firdous et al.
Ageing has been recognized as the leading risk factor for Alzheimer's disease (AD), with an intricate interplay of oxidative stress, neuroinflammation, and cellular senescence implicated in its pathogenesis. Mitochondrial dysfunction has be...
Unrevealing possible mechanism of Riluzole, Salsalate and Nimodipine in Alzheimer's disease: multi-target network pharmacological perspective [0.03%]
雷鲁唑、水杨酸钠和尼莫地平治疗阿尔茨海默病的多靶点网络药理学研究
Kishor Kumar Roy,Dinesh Kumar Mehta,Rina Das
Kishor Kumar Roy
Prebiotics attenuate depressive-like behavior, neuroinflammation and synaptic plasticity in Parkinson's disease by modulating butyrate-producing gut bacteria [0.03%]
益生元通过调节产丁酸盐的肠道菌群缓解帕金森病类似抑郁行为、神经炎症和突触可塑性损伤
Ingrid Prata de Mendonça,Rodrigo Soares da Silva,Igor Henrique Rodrigues de Paiva et al.
Ingrid Prata de Mendonça et al.
Parkinson's disease (PD) remains a challenging disease for treatment, which is usually polypharmacological. In addition to motor symptoms, non-motor symptoms such as depression are present in approximately 40% of patients, contributing to t...
Design, synthesis, in-vitro hydrolysis and biological evaluation of antioxidant conjugated mutual prodrugs of ibuprofen [0.03%]
布洛芬抗氧化共轭互助前药的设计、合成、体外水解及其生物活性评价
Rajat Goyal,Prabodh Chander Sharma,Sumeet Gupta
Rajat Goyal
A novel series of antioxidant-conjugated mutual prodrugs of ibuprofen (RJ-02-01 to RJ-02-10) was designed and synthesized to address the gastrointestinal (GI) toxicity. Ibuprofen was covalently linked to substituted aniline-based antioxidan...
Trehalose as an anti-inflammatory agent: insights into molecular mechanisms and therapeutic applications [0.03%]
trehalose的抗炎作用：分子机制及治疗应用的新见解
Shabnam Radbakhsh,Mohamed Benderdour,Yasmine Maanani et al.
Shabnam Radbakhsh et al.
Symbiotic in Alzheimer's disease: modulating the gut-brain axis for neuroimmune homeostasis and cognitive protection [0.03%]
阿尔茨海默病中的共生关系：调节肠-脑轴以实现神经免疫稳态和认知保护
Snehashis Mandal,Khadga Raj Aran
Snehashis Mandal
Alzheimer's disease (AD) is a multifactorial neurodegenerative disorder defined by progressive cognitive impairment, neuroinflammation, oxidative stress, amyloid-β (Aβ) accumulation, synaptic dysfunction, mitochondrial impairment, and tau...
Non-covalent proteasome inhibitor PI1840 suppresses osteoclastogenesis and prevents LPS-induced osteolysis in mice [0.03%]
非共价连接的蛋白酶体抑制剂PI1840可抑制破骨细胞生成并预防小鼠内毒素诱导的骨溶解
Yehua Xia,Fuli Zhao,Cheng Dang et al.
Yehua Xia et al.
Excessive osteoclast-mediated bone resorption is a hallmark of osteolytic disorders, including aseptic prosthetic loosening, osteoporosis, and rheumatoid arthritis. Therefore, the identification of agents that effectively suppress osteoclas...