Dapagliflozin mitigates acute pancreatitis induced by L-arginine in Rats through modulation of TLR-4/NF-κB/NLRP3 pathway: integrated biochemical, histopathological, and in silico study [0.03%]
Mohamed Kh Elmahdy,Ehab A M El-Shoura,Ahmed A Al-Karmalawy et al.
Mohamed Kh Elmahdy et al.
Background: Acute pancreatitis (AP) is one of the most common gastrointestinal disorders requiring hospitalization worldwide and is characterized by excessive inflammatory and oxidative responses that contribute to pancre...
Pharmaco-therapeutic modulation of the Glo1-Nrf2-RAGE functional network in chronic inflammation: polyphenols in the context of current anti-inflammatory therapy [0.03%]
Sajid Ali,Muhammad Saeed Akhtar,Adnan Amin et al.
Sajid Ali et al.
Chronic inflammation is a central driver of numerous disorders, including metabolic, cardiovascular, neurodegenerative, autoimmune, and malignant diseases. Although current anti-inflammatory pharmaco-therapeutic strategies, including nonste...
Combatting psoriasis with nanomedicine: gamma-amino butyric acid-chitosan nanoparticles as a targeted anti-psoriatic therapy [0.03%]
Dina Ibrahim,Alyaa Farid,Mohamed Kishta et al.
Dina Ibrahim et al.
The chronic inflammation and oxidative stress are the most deleterious pathogenic factors of psoriasis (PS). While gamma-aminobutyric acid (GABA) possesses well-documented immunomodulatory and antioxidant properties, its therapeutic potenti...
Medicinal plants as alternative and adjunct antimicrobial agents in ear, nose, and throat (ENT) Infections [0.03%]
Serpil Demirci Kayıran,Talih Özdaş,Umay Merve Güven Bölgen et al.
Serpil Demirci Kayıran et al.
Medicinal plants are widely used worldwide for ear, nose, and throat (ENT) disorders and have a long history of traditional application. This review aims to summarize current experimental and clinical evidence on medicinal plants used for E...
Boswellia serrata dry extract with intestinal anti-inflammatory properties also accelerates gastric ulcer healing in rats [0.03%]
Franco Giovanni Sandri Serafim,Lucas Fontana Breguez da Cunha,Larissa Venzon et al.
Franco Giovanni Sandri Serafim et al.
Boswellia serrata is a medicinal plant traditionally used to treat inflammatory conditions and this study aimed to evaluate the efficacy of B. serrata dry extract (BSDE) in treating gastric ulcers and ulcerative colitis. Chronic gastric ulc...
Network pharmacology and in vivo experimental analysis for validating the antifibrotic potential of Punica granatum leaves against skin scleroderma: the role of oxidative stress, inflammation and TGF-β1/Snail 1/p-Smad 3 signaling pathway [0.03%]
Sara M Baraka,Zeinab A El-Gendy,Eman A W El-Abd et al.
Sara M Baraka et al.
Given the significant efficacy of the Punica granatum in enhancing skin health, this research employed network pharmacology and in vivo studies to explore the P. granatum ethanolic leaf extract's (PGEL) mechanism in alleviating skin scleros...
Metformin for knee osteoarthritis in overweight and obese adults: a systematic review and meta-analysis of efficacy, safety, and disease-modifying anti-inflammatory potential [0.03%]
Santenna Chenchula,Krishna Chaitanya Amerneni,R Padmavathi et al.
Santenna Chenchula et al.
Introduction: Knee osteoarthritis (OA) is a degenerative joint disease involving progressive cartilage loss, subchondral bone remodelling, and inflammation. This systematic review and meta-analysis aimed to assess the eff...
Chitosan-curcumin nanoparticles: a potential nano-therapeutic for cognitive restoration in a streptozotocin-induced rat model of Alzheimer's disease [0.03%]
Mohadeseh Shiravi Khozani,Mohammadreza Palizvan,Ghasem Mosayebi et al.
Mohadeseh Shiravi Khozani et al.
Background: Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline and memory impairment, with no definitive cure currently available. Neuroinflammation, oxidative stress, ...
Amelioration of experimentally induced-arthritis by guaiazulene through targeting inflammatory and oxidative stress biomarkers in Wistar rat [0.03%]
Ammara Saleem,Arooj Fatima,Muhammad Furqan Akhtar
Ammara Saleem
Rheumatoid arthritis (RA), a systemic autoimmune disease, is related with the symmetrical synovitis of the joints which causes joint pain. The intake of anti-rheumatic drugs can lead to several adverse effects. Phytochemicals are effective ...
Aqueous extract of Psidium glaziovianum Kiaersk leaves acts on muscarinic and opioid receptors and reduces cytokines and inflammatory infiltrates in vivo models [0.03%]
Wêndeo Kennedy Costa,Paulo Henrique Eloi Fernandes,Paloma Maria da Silva et al.
Wêndeo Kennedy Costa et al.