Nature meets immunity: curcumin's role in modulating neutrophil extracellular traps [0.03%]
自然与免疫相遇：姜黄素在调节中性粒细胞胞外陷阱中的作用
Amirhossein Sahebkar,Elaheh Mirhadi,Tannaz Jamialahmadi et al.
Amirhossein Sahebkar et al.
NETosis represents a distinct type of neutrophil activation, marked by the discharge of neutrophil extracellular traps (NETs) network-like formations mainly consisting of decondensed chromatin interspersed with antimicrobial proteins source...
RGRN-305, a novel Hsp90 inhibitor: a promising therapeutic option for inflammatory dermatologic diseases [0.03%]
新型Hsp90抑制剂RGN-305可成为炎症性皮肤病的治疗选择
Nazila Heidari,Homayoun Pishraft-Sabet,Rayhaneh Gol et al.
Nazila Heidari et al.
Heat shock protein 90 (Hsp90) is a molecular chaperone that plays a critical role in cellular homeostasis and influences various cellular processes. Recent research has revealed its involvement in inflammatory skin diseases, suggesting that...
Neuroprotective role of cyanidin in Alzheimer's and Parkinson's disease: current insights and the road ahead [0.03%]
Cyanidin在阿尔茨海默病和帕金森病中的神经保护作用：当前见解及未来方向
Bushra Bashir,Nandani Andotra,Prince Sharma et al.
Bushra Bashir et al.
Neurodegenerative diseases (NDs), including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive neuronal loss within the central nervous system, affecting more than 64 million individuals worldwide. Degen...
Therapeutic update on alopecia areata: a critical review of standard and emerging targeted therapies [0.03%]
关于斑秃治疗的最新进展：标准和新兴靶向治疗的批判性回顾
Francesco Ferrara
Francesco Ferrara
Background and objectives: This narrative review provides a comprehensive update on the pathogenesis and therapeutic management of alopecia areata (AA), critically evaluating the transition from non-specific immunosuppres...
Zaleya pentandra L. produces anti-arthritic effects by downregulating IL-6, NF-κB, and TNF-α and mitigating oxidative stress [0.03%]
扎利娅五腺通过下调IL-6、NF-κB和TNF-α以及缓解氧化应激产生抗关节炎作用
Ayesha Shafi,Naureen Shehzadi,Khalid Hussain et al.
Ayesha Shafi et al.
Background: Zaleya pentandra L. (Aizoaceae) is traditionally used to treat various ailments including inflammatory conditions, but the literature is scant regarding its role in chronic inflammation. Therefore, the current...
Immunological, anti-inflammatory, and anti-oxidant effects of Fig and Olive leaves extracts nanoparticles against Schistosoma mansoni in C57BL/6 mice [0.03%]
纳米化无花果和橄榄叶提取物对C57BL/6小鼠中曼氏血吸虫感染的免疫学、抗炎及抗氧化作用
Naira A El-Attar,Eman A El-Shabasy,Mamdouh R El-Sawi
Naira A El-Attar
Schistosomiasis, caused by worms of the genus Schistosoma, especially S. mansoni, remains a major global health challenge, with over 200 million people infected annually. Notably, sterile immunity does not naturally develop, and drug select...
Multi-target therapeutic potential of Flavokawain A in rheumatoid arthritis: A mechanistic and translational perspective [0.03%]
胡椒灵草素A治疗类风湿性关节炎的多靶点治疗潜力：机制与转化视角
Goparaju Kavya,Vancha Harish,Palakurthi Yanadaiah et al.
Goparaju Kavya et al.
Rheumatoid arthritis (RA) commonly affects synovial joints, characterised by inflammation, progressive joint destruction, and multi-organ involvement. Despite major advances in pharmacological management with DMARDs, RA remains incurable, w...
Inhibiting pyruvate carboxylase as a potential therapeutic strategy for alleviating rheumatoid arthritis [0.03%]
丙酮酸羧化酶抑制作为缓解类风湿关节炎的潜在治疗策略
Szu-Wei Huang,Hui-Chun Yu,Hsien-Bin Huang et al.
Szu-Wei Huang et al.
Background: Rheumatoid arthritis (RA) is marked by synovial inflammation, cartilage loss, and bone erosion, with macrophages playing a central role. Pyruvate carboxylase (PC), a mitochondrial enzyme, has been linked to in...
Selenium nanoparticle-enhanced resveratrol suppresses pulmonary inflammation and fibrogenesis in silicosis via redox-mediated inflammatory pathway modulation [0.03%]
硒纳米颗粒增强白藜芦醇通过氧化还原介导的炎症通路调节抑制硅肺炎和纤维化生成
Ola A Habotta,Lashin Ali,Nuha Anajirih et al.
Ola A Habotta et al.
Silicosis, an occupational lung illness linked to the inhalation of silica (Si) particles, is marked by enduring oxidative stress, chronic inflammation, and advancing pulmonary fibrosis. This work conducted a comparative assessment of the t...
Daphnetin prevents acute graft-versus-host disease by suppressing donor T cell expansion and function [0.03%]
大良碱通过抑制移植物T细胞的增殖和功能预防急性移植物抗宿主病
Zhi-Feng Wei,Yan-Fang Chen,Fei Song et al.
Zhi-Feng Wei et al.
Background: Acute graft-versus-host disease (aGVHD), which is primarily driven by donor alloreactive T cells, is a major cause of morbidity and mortality following allogeneic hematopoietic cell transplantation (allo-HCT)....