Navigating the maze of Alzheimer's: nimodipine and pioglitazone combination in the spotlight through inhibition of P2X7 dependent NLRP3 inflammasome activation [0.03%]
阿尔茨海默病迷宫中的导航：尼莫地平和吡格列酮联合通过抑制P2X7依赖的NLRP3炎性小体激活而成为焦点
Antony Justin,Chennu Manisha,Sayani Banerjee et al.
Antony Justin et al.
From insult to hyperexcitability: pharmacological targeting of MyD88 and JAK/STAT3 pathways in epilepsy [0.03%]
从侮辱到过度兴奋：针对癫痫中MyD88和JAK / STAT3途径的药理靶向作用
Ahmed M Abdelaziz,Mohamed N Fawzy,Mohamed K Fathy et al.
Ahmed M Abdelaziz et al.
Neuroinflammation is hypothesized to be a fundamental driver of epileptogenesis, potentially contributing to the transformation of the healthy brain into a state prone to spontaneous recurrent seizures. This manuscript explores the pivotal ...
Ameliorative effects of Mucuna imbricata on inflammation and oxidative stress in a rat edema model [0.03%]
印度假豆叶提取物对大鼠炎症和氧化应激的改善作用研究
Suresh Suryawanshi,Chetan Aware,Viresh Thamke et al.
Suresh Suryawanshi et al.
Plants of the genus Mucuna have ethnomedicinal importance, several pharmacological activities along with its higher L-DOPA content as an anti-parkinson's drug. This study demonstrated the sub-acute lethality and anti-inflammatory potential ...
HMGB1-mediated neuroinflammation: molecular mechanisms and emerging therapeutic approaches [0.03%]
HMGB1介导的神经炎症：分子机制和新兴治疗策略
Khalil Nuruddeen Ibrahim,Rufaida Wasim,Ebadur Rahman
Khalil Nuruddeen Ibrahim
High mobility group box 1 (HMGB1) has emerged as a central inflammatory mediator linking cellular stress and tissue injury to sustained neuroinflammation in the central nervous system. Although originally characterized as a nuclear chromati...
Phytochemicals in arthritis management: insight into pharmacodynamic potency with pharmacokinetic profile [0.03%]
植物化学成分在关节炎管理中的作用：具有药动学特征的药理活性分析
Juganta Kumar Kalita,N Anirudh Singh,Shriyeta Biswas et al.
Juganta Kumar Kalita et al.
Chemical profile and anti-inflammatory activity of the hydroethanolic extract of Cochlospermum regium (Schrank) Pilg. xylopodium [0.03%]
Cochlospermum regium (Schrank) Pilg. xylopodium的羟乙醇提取物化学成分及其抗炎活性研究
Jessica de Araujo Isaias Muller,Bruna Fioravante Di Serio,Fabiana de Freitas Figueiredo et al.
Jessica de Araujo Isaias Muller et al.
A comprehensive review of the phytochemical, and pharmacological potential of Alnus hirsuta (Spach) Rupr., (Siberian Alder): implications for anti-inflammatory therapeutics [0.03%]
全面综述白桦属(Salix)植物毛叶柳的化学和药理潜力：对抗炎药物的意义
Sajid Ali,Adnan Amin,Muhammad Saeed Akhtar et al.
Sajid Ali et al.
Alnus hirsuta (Siberian alder), a member of the family Betulaceae, is a medicinally significant species that has yet to be the subject of a comprehensive review. This article summarizes phytochemical constituents, and pharmacological activi...
Effect of vitamin D3 supplementation on systemic inflammation and disease-specific markers in patients with autoimmune diseases: a comprehensive meta-analysis of randomized controlled trials [0.03%]
维生素D3补充对自身免疫性疾病患者全身炎症和疾病特异性标志物的影响：随机对照试验的综合meta分析
Amirreza Jabbari,Hadi Esmaeili Gouvarchin Ghaleh,Mina Alimohammadi et al.
Amirreza Jabbari et al.
Background: The immunomodulatory role of vitamin D3 in autoimmune diseases is widely hypothesized, but its therapeutic efficacy remains contested. This meta-analysis quantifies the effect of vitamin D3 supplementation on ...
Auranofin reimagined: an emerging therapeutic candidate for neurodegenerative diseases through molecular mechanistic insights [0.03%]
基于分子机制见解的治疗神经退行性疾病的新疗法候选药物Auranofin
Kanika Vashisht,Himanshu Kumar,Amardeep Ankalgi et al.
Kanika Vashisht et al.
Synergistic modulation of nociceptive and inflammatory pain by palmitoylethanolamide and Cucumis sativus extract in a monosodium-iodoacetate induced osteoarthritic rat model [0.03%]
用单钠碘乙酸诱导的骨关节炎大鼠模型研究月见草提取物与棕榈酰乙醇胺对疼痛的协同调节作用
Om Prakash Sharma,Radika Sharma
Om Prakash Sharma
Background: Osteoarthritis (OA) is a progressive degenerative joint disease characterized by chronic inflammation, cartilage degradation, and persistent pain, leading to functional disability and reduced quality of life. ...