Epigallocatechin-3-gallate (EGCG) as a molecular chaperone and network rebalancer in neurodegenerative diseases [0.03%]
表没食子儿茶素没食子酸酯（EGCG）作为分子伴侣和网络调节剂在神经退行性疾病中的作用
Husni Farah,Media Hamed Ahmed,Shaker Al-Hasnaawei et al.
Husni Farah et al.
Epigallocatechin-3-gallate (EGCG), the primary catechin in green tea, has emerged as a paradigmatic multi-target molecule capable of modulating convergent molecular processes underlying neurodegenerative diseases such as Alzheimer's and Par...
Reprogramming immunity: the promise and challenges of CAR T cell therapy in multiple sclerosis [0.03%]
免疫重编程：CAR-T细胞治疗在多发性硬化症中的前景与挑战
Nitik Kumawat,Aarti Sharma,Shubham Upadhayay
Nitik Kumawat
Introduction: Chimeric antigen receptor T-cell (CAR-T) therapy was initially used to treat B-cell malignancies, and it is now considered an effective treatment option for multiple sclerosis (MS). CAR-T therapy selectively...
Chemical characterization and antinociceptive and anti-inflammatory activities of the aqueous extract of Myrciaria floribunda (H. West ex Willd.) O. Berg fruit peel [0.03%]
Myrciaria floribunda(O.Berg)果皮的化学成分及镇痛和抗炎作用研究
Simone Patricia De Freitas Rosa,Izabelly Bianca da Silva Santos,Wendel César eSilva Pereira et al.
Simone Patricia De Freitas Rosa et al.
Natural products derived from medicinal plants represent an important source of bioactive compounds with potential therapeutic applications in the management of pain and inflammatory disorders. In this study, the chemical profile and pharma...
Ruxolitinib phosphate-laden nanoemulgel: amelioration of ex vivo permeation and in vivo therapeutic efficacy for the effective therapeutic management of psoriasis [0.03%]
鲁索利替尼磷酸盐纳米乳凝胶：改善体外渗透和体内治疗效果以有效管理银屑病
Ratnam Sreya,Shweta Nene,Vrushali Pathade et al.
Ratnam Sreya et al.
Psoriasis is a chronic, immune-driven inflammatory skin ailment marked by recurrent flare-ups. Ongoing clinical investigations are focused on therapeutic strategies that modulate key signaling pathways implicated in disease pathogenesis. Ru...
In vitro ibuprofen has gene regulatory and anti-inflammatory properties in peripheral blood mononuclear cells of individuals with infection-provoked neurodevelopmental disorders [0.03%]
体外研究发现布洛芬具有基因调节和抗炎作用：感染诱发的神经发育障碍患者的外周血单个核细胞研究
Velda X Han,Jessica P Hayes,Brian Gloss et al.
Velda X Han et al.
Gene-environment interactions, leading to immune-brain cross-talk and neuroinflammation are increasingly recognised in neurodevelopmental disorders (NDDs), such as autistic regression and paediatric acute onset neuropsychiatric syndrome (PA...
Exploration of molecular mechanisms responsible for arthritis alleviating attributes of Calliandra haematocephala extracts [0.03%]
决明.calliandra haematocephala.抗关节炎的作用及机制研究
Inaam Ur Rehman,Taha Muhammad,Abir Abdullah Alamro et al.
Inaam Ur Rehman et al.
Inflammation and autoimmunity create a complex array of pathological parameters to induce rheumatoid arthritis (RA) that is primarily a disease of the musculoskeletal system. To date, there is no cure for RA. The purpose of the present stud...
Salivary protein macromolecules as diagnostic and therapeutic biomarkers linking oral health and neurodegenerative diseases-emerging mechanisms and future perspectives [0.03%]
唾液蛋白大分子作为诊断和治疗生物标志物在口腔健康与神经退行性疾病之间的联系新兴机制及未来前景
Pranav Dhingra,Aman Kumar,Pooja Mongia Raj et al.
Pranav Dhingra et al.
Oral diseases and neurodegenerative diseases represent two overlapping global health challenges, driven by shared risk factors and the rapid ageing of the population. Emerging evidence suggests that the oral-brain axis functions as a critic...
Anti-osteoporotic potential of Lawsonia inermis leaf extract: integration of network pharmacology, molecular docking, and experimental validation in ovariectomized rats [0.03%]
网络药理学、分子对接和实验验证整合研究辣木叶提取物抗骨质疏松潜力
Deepa S Mandlik,Mitali P Lavhale,Satish K Mandlik
Deepa S Mandlik
With an emphasis on modulation of the oestrogen receptor (ER)/osteoprotegerin (OPG)/receptor activator of nuclear factor-κβ ligand (RANKL) signalling pathway, the current study sought to explore the anti-osteoporotic potential of Lawsonia...
Targeting inflammaging in Alzheimer's disease: molecular pathways and emerging pharmacotherapies [0.03%]
阿尔茨海默病炎症衰老的治疗靶点：分子通路及新兴药物疗法
Modhi O Alotaibi,Hayder M Al-Kuraishy,Esraa Hammadi Fahad et al.
Modhi O Alotaibi et al.
Alzheimer's disease (AD), the leading cause of dementia, is intrinsically linked to the aging process. A central mechanism driving this association is inflammaging, a state of chronic, low-grade inflammation resulting from innate immune dys...
Curcumin as a multi-target therapy for osteoarthritis in rats: a systematic review and meta-analysis [0.03%]
姜黄素作为治疗大鼠骨关节炎的多靶点疗法：系统评价和Meta分析
Hao Liu,Zixiang Ye,Chenjia Wu et al.
Hao Liu et al.
Osteoarthritis (OA) represents a significant unmet clinical need, where current management strategies primarily alleviate symptoms but fail to halt disease progression and are often associated with adverse effects. Curcumin, a natural polyp...