Rhein methotrexate-decorated solid lipid nanoparticles altering adjuvant arthritis progression through endoplasmic reticulum stress-mediated apoptosis [0.03%]
雷公藤甲氨蝶呤修饰的固脂纳米粒通过内质网应激诱导凋亡抑制佐剂性关节炎恶化
Wessam M El-Refaie,Mostafa S Ghazy,Fady A Ateyya et al.
Wessam M El-Refaie et al.
Methotrexate (MTX) and diacerein (DIA) are two of the most potent disease-modifying anti-rheumatic drugs used for the treatment of rheumatoid arthritis (RA). DIA has reflected some GIT and hepatobiliary manifestations in numerous cases. It ...
Narcotic analgesics [0.03%]
麻醉性镇痛药
W Watson Buchanan,K D Rainsford,Colin A Kean et al.
W Watson Buchanan et al.
There is documentation of the use of opium derived products in the ancient history of the Assyrians: the Egyptians; in the sixth century AD by the Roman Dioscorides; and by Avicenna (980-1037). Reference to opium like products is made by Pa...
Oxymatrine-mediated prevention of amyloid β-peptide-induced apoptosis on Alzheimer's model PC12 cells: in vitro cell culture studies and in vivo cognitive assessment in rats [0.03%]
苦参碱介导的淀粉样蛋白β多肽所致阿尔茨海默病模型PC12细胞凋亡的抑制作用：体外细胞培养研究与动物认知评估实验
Yue Zhu,Zhuo Wang,Chao Gao et al.
Yue Zhu et al.
Alzheimer's disease (AD) is a major neurological disease affecting elderly individuals worldwide. Existing drugs only reduce the symptoms of the disease without addressing the underlying causes. Commonly, Aβ25-35 peptide aggregation is the...
The effects of pomegranate consumption on inflammatory and oxidative stress biomarkers in adults: a systematic review and meta-analysis [0.03%]
成人食用石榴对炎症和氧化应激生物标志物的影响：系统评价和meta分析
Hossein Bahari,Hossein Rafiei,Kian Goudarzi et al.
Hossein Bahari et al.
Background: Several studies have shown the effects of pomegranate on oxidative stress and inflammation biomarkers, while some studies showed no effects of pomegranate on these biomarkers. Therefore, we aimed to evaluate t...
Essential oil from leaves of Myrciaria floribunda (H. West ex Willd.) O. Berg has antinociceptive and anti-inflammatory potential [0.03%]
Myrciaria floribunda（H. West ex Willd.）O. Berg的叶子精油具有镇痛和抗炎潜力
Priscilla Glazielly Dos Santos de Moraes,Izabelly Bianca da Silva Santos,Valquíria Bruna Guimarães Silva et al.
Priscilla Glazielly Dos Santos de Moraes et al.
Myrciaria floribunda is a plant that is distributed across different Brazilian biomes such as the Amazon, Caatinga, Cerrado, and Atlantic Forest, and it possesses antioxidant, antimicrobial, and anticancer properties. The antinociceptive an...
Hedieh Sadat Shamsnia,Mahtab Roustaei,Danial Ahmadvand et al.
Hedieh Sadat Shamsnia et al.
Curcumin (diferuloylmethane) is a herbal remedy which possesses numerous biological attributes including anti-inflammatory, anti-oxidant and anti-cancer properties. Curcumin has been shown to impact a number of signaling pathways including ...
Ameliorative effect of montelukast against STZ induced diabetic nephropathy: targeting HMGB1, TLR4, NF-κB, NLRP3 inflammasome, and autophagy pathways [0.03%]
蒙特鲁卡斯特对链佐星诱导的糖尿病肾病改善作用：靶向HMGB1、TLR4、NF-κB、NLRP3炎性小体和自噬途径
Ahmed M Awad,Sally L Elshaer,Rajashekhar Gangaraju et al.
Ahmed M Awad et al.
Diabetic nephropathy (DN) is reported as one of the most serious microvascular diabetic complications and the trigger of end-stage renal disease (ESRD), underscoring the concern of any therapeutic intervention directed at ameliorating the d...
Methotrexate is associated with decreased total thyroxine in patients with rheumatoid arthritis [0.03%]
甲氨蝶呤与类风湿关节炎患者的总甲状腺素降低有关
Shu-Lin Chen,Qiang Xu,Chang-Song Lin
Shu-Lin Chen
Background: Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by joint swelling, pain, and deformation. RA patients have an increased risk of thyroid dysfunction, and drugs of RA treatme...
Vitamin K2 protects against aluminium chloride-mediated neurodegeneration [0.03%]
维生素K2能够保护神经细胞免于氯化铝导致的退变损伤
Kaberi Chatterjee,Papiya Mitra Mazumder,Sugato Banerjee
Kaberi Chatterjee
Recent studies have shown that, coupled with other environmental factors, aluminium exposure may lead to neurodegeneration resulting in cognitive impairment resembling Alzheimer's disease. Menaquinone, a form of vitamin K2, aids in maintain...
PPARγ partial agonist LPSF/GQ-16 prevents dermal and pulmonary fibrosis in HOCl-induced systemic sclerosis (SSc) and modulates cytokine production in PBMC of SSc patients [0.03%]
PPARγ部分激动剂LPSF / GQ-16可预防HOCl诱导的系统性硬化症(SSc)引起的皮肤和肺纤维化并调节SSc患者PBMC中细胞因子产生
Anderson Rodrigues de Almeida,Andréa Tavares Dantas,Maria Eduarda de Oliveira Gonçalves et al.
Anderson Rodrigues de Almeida et al.
Thiazolidinediones (TZD) are synthetic molecules that have a range of biological effects, including antifibrotic and anti-inflammatory, and they may represent a promising therapeutic strategy for systemic sclerosis (SSc). The aim of this st...