ELK1 activated-long noncoding RNA LBX2-AS1 aggravates the progression of ovarian cancer through targeting miR-4784/KDM5C axis [0.03%]
ELK1激活的长非编码RNA LBX2-AS1通过靶向miR-4784/KDM5C轴加重卵巢癌的进展
Hangzhi Gu,Rongrong Lin,Feiyun Zheng et al.
Hangzhi Gu et al.
As one of the most common cancers in female, ovarian cancer (OC) has become a serious public burden now. Mounting researches have indicated long noncoding RNAs (lncRNAs) can affect many biological processes including cancer development. Lnc...
MMP7 damages the integrity of the renal tubule epithelium by activating MMP2/9 during ischemia-reperfusion injury [0.03%]
在缺血再灌注损伤过程中,MMP7通过激活MMP2/9损害肾小管上皮的完整性
Qianchao Hu,Jianan Lan,Wenjin Liang et al.
Qianchao Hu et al.
Renal ischemia-reperfusion (IR) injury is a common issue in urological surgery, and the renal tubules, particularly the proximal tubules, are extremely vulnerable to IR injury. In this work, we detected the differently expressed genes (DEGs...
Metabolic acidosis and hyperkalemia differentially regulate cation HCN3 channel in the rat nephron [0.03%]
代谢性酸中毒和高钾血症差异性调节大鼠肾小管中的阳离子HCN3通道
Zinaeli López-González,Teresa Padilla-Flores,Daniel León-Aparicio et al.
Zinaeli López-González et al.
The kidney controls body fluids, electrolyte and acid-base balance. Previously, we demonstrated that hyperpolarization-activated and cyclic nucleotide-gated (HCN) cation channels participate in ammonium excretion in the rat kidney. Since ac...
ITGB1 promotes the chondrogenic differentiation of human adipose-derived mesenchymal stem cells by activating the ERK signaling [0.03%]
ITGB1通过激活ERK信号促进人脂肪来源的间充质干细胞的软骨形成分化
Simin Luo,Qiping Shi,Wuji Li et al.
Simin Luo et al.
Adipose-derived mesenchymal stem cell (ADSC) with a high capacity of chondrogenic differentiation was a promising candidate for cartilage defect treatment. This study's objective is to study the roles of integrin β1 (ITGB1) in regulating A...
Breast tumour cell subpopulations with expression of the MYC and OCT4 proteins [0.03%]
表达MYC和OCT4蛋白的乳腺肿瘤细胞亚群
N V Litviakov,V A Bychkov,M N Stakheeva et al.
N V Litviakov et al.
The MYC and OCT4 genes are known factors associated with maintaining pluripotency and are linked with a more aggressive course, progression, and resistance to therapy in cancer. Determining the subpopulations of tumour cells expressing the ...
Long non-coding RNAs as targets for immunosuppressive drug teriflunomide in anti-cancer potential for hepatocellular carcinoma [0.03%]
长链非编码RNA作为免疫抑制药物特氟诺米德在肝细胞癌抗肿瘤潜力中的靶点
Yinkai Xu,Daoming Shen,Jianxia Liu et al.
Yinkai Xu et al.
Hepatocellular carcinoma (HCC) is the most common form of liver cancer. Because of the relatively chemotherapy-refractory nature of HCC and significant potential poor hepatic reserve, chemotherapy has not been used consistently in the treat...
COVID-19 and multiorgan failure: A narrative review on potential mechanisms [0.03%]
COVID-19与多器官功能障碍：潜在机制的叙述性评论
Tahmineh Mokhtari,Fatemeh Hassani,Neda Ghaffari et al.
Tahmineh Mokhtari et al.
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV2) in December 2019 form Wuhan, China leads to coronavirus disease 2019 (COVID-19) pandemic. While the common cold symptoms are observed in mild cases, COVID-19 is acc...
Hedgehog pathway activation in oral squamous cell carcinoma: cancer-associated fibroblasts exhibit nuclear GLI-1 localization [0.03%]
口腔鳞状细胞癌中刺猬通路的活化：与癌症相关的成纤维细胞出现GLI-1核定位现象
Vanessa Sousa Nazare Guimaraes,Manuela Torres Andion Vidal,Ludmila de Faro Valverde et al.
Vanessa Sousa Nazare Guimaraes et al.
The purpose of this study was to evaluate the expression of Hedgehog (HH) signaling molecules (SHH and GLI-1) by cancer-associated fibroblasts (CAF) in oral squamous cell carcinoma (OSCC). Immunohistochemistry was used to detect molecular H...
Association of high HIF-1α levels in serous periodontitis with external root resorption by the NFATc1 pathway [0.03%]
高HIF-1α水平与牙周炎根面外吸收的关联性研究
Changjie Xiao,Guangliang Bai,Yanmei Du et al.
Changjie Xiao et al.
Whether external root resorption is associated with hypoxia in the periodontal ligaments of teeth with severe periodontitis remains unclear. Hypoxia inducible factor-1α (HIF-1α) expression and external resorption sites in the periodontal ...
Lycium barbarum polysaccharide protects against Homocysteine-induced Vascular smooth muscle cell proliferation and phenotypic transformation via PI3K/Akt pathway [0.03%]
枸杞多糖通过PI3K/Akt信号通路保护血管平滑肌细胞免受同型半胱氨酸诱导的增殖和表型转换
Minghao Zhang,Fan Li,Smritee Pokharel et al.
Minghao Zhang et al.
Lycium barbarum polysaccharide (LBP) is an alkaloid extracted from lycium barbarum. LBP is the active component of lycium barbarum used to treat hypertension, atherosclerosis and other cardiovascular diseases in Chinese traditional medicine...