Coenzyme Q10 enhances remyelination and regulate inflammation effects of cuprizone in corpus callosum of chronic model of multiple sclerosis [0.03%]
辅酶Q10改善进行性多发性硬化模型胼胝体杯rizone区脱髓鞘及炎症反应作用的研究
Behnam Khalilian,Soheila Madadi,Nima Fattahi et al.
Behnam Khalilian et al.
Multiple Sclerosis (MS) is a chronic, progressive demyelinating disease of the central nervous system that causes the most disability in young people, besides trauma. Coenzyme Q10 (CoQ10)-also known as ubiquinone-is an endogenous lipid-solu...
Julio Plaza-Díaz,Ana I Álvarez-Mercado,Cándido Robles-Sánchez et al.
Julio Plaza-Díaz et al.
The neuronal apoptosis inhibitory protein (NAIP) is a constituent of the NLRC4 inflammasome, which plays a key role in innate immunity, and an antiapoptotic protein. Recently, we reported the previously undescribed role of NAIP in cell divi...
Peiyao Li,Huiru Jing,Yanzhe Wang et al.
Peiyao Li et al.
Apoptosis and clearance of dead cells is highly evolutionarily conserved from nematode to humans, which is crucial to the growth and development of multicellular organism. Fail to remove apoptotic cells often lead to homeostasis imbalance, ...
Dual roles of TGF-β signaling in the regulation of dental epithelial cell proliferation [0.03%]
TGF-β信号在调节牙源上皮细胞增殖中的双重作用
Hao Zhang,Yunyan Zhan,Yue Zhang et al.
Hao Zhang et al.
The purpose of this study is to investigate the molecular mechanisms and biological function of TGF-β-activated Smad1/5 in dental epithelium. Immunohistochemistry was used to detect the expressions of TGF-β signaling-related gene in mice ...
NDRG2 is expressed on enteric glia and altered in conditions of inflammation and oxygen glucose deprivation/reoxygenation [0.03%]
NDRG2在肠胶质细胞中表达并在炎症和缺氧葡萄糖剥夺/复氧条件下发生改变
Yuxin Zhang,Hui Gao,Na Li et al.
Yuxin Zhang et al.
Enteric glial cells are more abundant than neurons in the enteric nervous system. Accumulating evidence has demonstrated that enteric glial cells share many properties with astrocytes and play pivotal roles in intestinal diseases. NDRG2 is ...
Transferrin improved the generation of cardiomyocyte from human pluripotent stem cells for myocardial infarction repair [0.03%]
转铁蛋白改善多能干细胞分化为治疗心肌梗死的心肌细胞
Fengzhi Zhang,Hui Qiu,Xiaohui Dong et al.
Fengzhi Zhang et al.
Human pluripotent stem cell (hPSC)-derived cardiomyocytes (CMs) hold great promise for the repair of the injured heart, but optimal cell production in a fully chemically defined and cost-effective system is essential for the efficacy and sa...
Altered BMP-Smad4 signaling causes complete cleft palate by disturbing osteogenesis in palatal mesenchyme [0.03%]
骨形态发生蛋白Smad4信号转导异常通过干扰腭间充质组织的骨生成而引起完全性唇裂腭裂综合征
Nan Li,Jing Liu,Han Liu et al.
Nan Li et al.
As the major receptor mediated BMP signaling in craniofacial development, Bmpr1a expression was detected in the anterior palatal shelves from E13.5 and the posterior palatal shelves from E14.5. However, inactivating BMP receptor in the mese...
Regulatory role of insulin-like growth factor-binding proteins in odontogenic mineralization in rats [0.03%]
胰岛素样生长因子结合蛋白在大鼠牙源性矿化中的调控作用
Jung-Sun Moon,Yoo-Sung Nam,Jee-Hae Kang et al.
Jung-Sun Moon et al.
Much information is currently available for molecules in early odontogenesis, but there is limited knowledge regarding terminal cytodifferentiation of ameloblasts and odontoblasts for the determination of normal crown morphology. The presen...
The role of MYB proto-oncogene like 2 in tamoxifen resistance in breast cancer [0.03%]
MYB原癌基因类似物2在乳腺癌他莫西芬耐药中的作用
Xia Li,Xi Zhang,Cong-Cong Wu et al.
Xia Li et al.
Despite the efficacy of tamoxifen in preventing disease relapse, a large portion of breast cancer patients show intrinsic or acquired resistance to tamoxifen, leading to treatment failure and unfavorable clinical outcome. MYB proto-oncogene...
TRIP13 promotes the proliferation and invasion of lung cancer cells via the Wnt signaling pathway and epithelial-mesenchymal transition [0.03%]
TRIP13通过Wnt信号通路和上皮间质转化促进肺癌细胞增殖和侵袭
Zhi-Han Li,Lei Lei,Liang-Ru Fei et al.
Zhi-Han Li et al.
Thyroid hormone receptor interactor 13 (TRIP13) is an ATPase that has been found to be overexpressed in many tumors. The aim of this study was to investigate the role of TRIP13 and its mechanism of action in lung cancer. The expression of T...