Overexpression of T-type calcium channel Cav3.1 in oral squamous cell carcinoma: association with proliferation and anti-apoptotic activity [0.03%]
Cav3.1钙通道在口腔鳞状细胞癌上过表达及其与肿瘤细胞增殖和抗凋亡活性的关系研究
Rui-Fang Li,Qi-Wen Man,Jin-Yuan Liu et al.
Rui-Fang Li et al.
Cav3.1, a subfamily of T-type calcium channel, is overexpressed in various human cancers and exerts important functions in tumor progression. This study is to identify the expression pattern and clinical significance of Cav3.1 in oral squam...
LncRNA KCNQ1OT1 acts as miR-216b-5p sponge to promote colorectal cancer progression via up-regulating ZNF146 [0.03%]
长链非编码RNA KCNQ1OT1通过上调ZNF146充当miR-216b-5p海绵促进结直肠癌进展
Shuang Zhu,Chih-Yen Chen,Yangyang Hao
Shuang Zhu
Long non-coding RNAs (lncRNAs) have shown to act as important regulators in cancer biology. The aim of this study was to investigate the role and mechanism of lncRNA KCNQ1 opposite strand/antisense transcript 1 (KCNQ1OT1) in colorectal canc...
Ubiquitin-specific protease 14 (USP14) promotes proliferation and metastasis in pancreatic ductal adenocarcinoma [0.03%]
泛素特异性蛋白酶14（USP14）可促进胰腺导管腺癌的增殖和转移
Cheng Hang,Chen Gong,Yanfei Fang et al.
Cheng Hang et al.
Previous studies have shown aberrant expression of ubiquitin-specific protease 14 (USP14) in multiple malignancies, suggesting an important role of USP14 in tumorigenesis. However, the functional role of USP14 in pancreatic ductal adenocarc...
High nuclear expression of APE1 correlates with unfavorable prognosis and promotes tumor growth in hepatocellular carcinoma [0.03%]
APE1高核表达与肝癌预后不良及促肿瘤生长有关
Xiaohua Lu,Hui Zhao,Hongxin Yuan et al.
Xiaohua Lu et al.
APE1 is a multifunctional protein that plays important roles in cancer development. However, the association between APE1 expression and the clinicopathological parameters of HCC patients has not been fully characterized. In this study, bio...
MiR-217 promotes endothelial cell senescence through the SIRT1/p53 signaling pathway [0.03%]
miR-217通过SIRT1/p53信号通路促进内皮细胞衰老
Zhibo Wang,Dianwei Shi,Nan Zhang et al.
Zhibo Wang et al.
Studies have shown that miR-217 can induce cell senescence, but its mechanism of action in vascular endothelial cell senescence is less reported. Therefore, this study aimed to investigate how miR-217 plays a role in endothelial cell senesc...
Polydatin and polydatin-loaded chitosan nanoparticles attenuate diabetic cardiomyopathy in rats [0.03%]
茋化合物及其壳聚糖纳米粒对糖尿病心肌病大鼠的治疗作用
Fatma Mostafa,Adel Abdel-Moneim,Manal Abdul-Hamid et al.
Fatma Mostafa et al.
Hyperglycemia is associated with impairment of heart function. The current study aimed to investigate the ameliorative effect of polydatin-loaded chitosan nanoparticles (PD-CSNPs), polydatin (PD) and metformin (MET) on diabetic cardiomyopat...
Salivary exosomes as a new therapy to ameliorate diabetes mellitus and combat xerostomia and submandibular salivary glands dysfunction in diabetic rats [0.03%]
唾液外泌体作为新的疗法以改善糖尿病并对抗糖尿病大鼠的口干和下颌下腺功能障碍
Zeinab A Salem,Amany Hany Mohamed Kamel,Nermeen AbuBakr
Zeinab A Salem
Diabetes mellitus (DM) is one of the major metabolic diseases. Xerostomia and salivary gland dysfunction are of its common oral complications. Exosomes, as a new therapeutic potential containing nucleic acids, proteins and lipids, act as ef...
LncRNA SNHG1 promotes neuronal injury in Parkinson's disease cell model by miR-181a-5p/CXCL12 axis [0.03%]
长链非编码RNA SNHG1通过miR-181a-5p/CXCL12轴促进帕金森病细胞模型中的神经元损伤
Hui Wang,Xiaopeng Wang,Yiying Zhang et al.
Hui Wang et al.
Small molecule RNA host gene 1 (SNHG1) has been found to be an important regulator in the neurotoxicity of Parkinson's disease (PD). However, the underlying molecular mechanisms of SNHG1 in PD remains elusive. The expression of SNHG1, micro...
Prognostic significance of LDL receptor-related protein 1B in patients with gastric cancer [0.03%]
LDL受体相关蛋白1B在胃癌患者中的预后价值
Itaru Yasufuku,Chiemi Saigo,Yusuke Kito et al.
Itaru Yasufuku et al.
LDLR-related protein 1B (LRP1B) is believed to internalize ligands through receptor-mediated endocytosis. Previous epigenetic and genetic studies have indicated that impaired LRP1B mRNA expression might be related to gastric carcinogenesis....
Uremic toxin indoxyl sulfate promotes proinflammatory macrophage activation by regulation of β-catenin and YAP pathways [0.03%]
尿毒症毒素吲哚硫酸盐通过调节β-连环蛋白和YAP信号通路促进促炎型巨噬细胞活化
Ying Li,Jing Yan,Minjia Wang et al.
Ying Li et al.
Evidence has been shown that indoxyl sulfate (IS) could impair kidney and cardiac functions. Moreover, macrophage polarization played important roles in chronic kidney disease and cardiovascular disease. IS acts as a nephron-vascular toxin,...