cIAP2 expression and clinical significance in pigmented villonodular synovitis [0.03%]
CIAP2在色素沉着性绒毛结节性滑膜炎中的表达及临床意义
Zhenyu Ding,Zhenlong Bai,Miao Zhang et al.
Zhenyu Ding et al.
Pigmented villonodular synovitis (PVNS) is a rare hyperplasia disease of the synovium with a predilection for the knee in either a localized (LPVNS) or a diffuse form (DPVNS). But the exact cause is not clear. The aim of this study was to e...
Synergistic effects of Indian hedgehog and sonic hedgehog on chondrogenesis during cartilage repair [0.03%]
印度干草虫毛花和音讯干草虫毛花在软骨修复过程中的诱导软骨生成的协同作用
Liyang Chen,Gejun Liu,Wenjun Li et al.
Liyang Chen et al.
Sonic hedgehog (Shh) and Indian hedgehog (Ihh) have been shown to control the induction of early cartilaginous differentiation. However, it is unclear whether Ihh and Shh exert synergistic effects on chondrogenesis during articular cartilag...
Semaphorin 3A promotes the osteogenic differentiation of rat bone marrow-derived mesenchymal stem cells in inflammatory environments by suppressing the Wnt/β-catenin signaling pathway [0.03%]
セマフォリン3A通过抑制Wnt/β-连环蛋白信号通路促进大鼠骨髓间充质干细胞在炎症环境中的成骨分化
Zhaoze Sun,Kaixian Yan,Shuang Liu et al.
Zhaoze Sun et al.
After periodontal treatment, the local inflammatory environment surrounding periodontal tissues cannot be entirely eliminated. The means by which alveolar bone repair and regeneration are promoted in inflammatory environments have important...
LGR4 silence aggravates ischemic injury by modulating mitochondrial function and oxidative stress via ERK signaling pathway in H9c2 cells [0.03%]
LGR4沉默通过ERK信号途径调节H9c2细胞线粒体功能和氧化应激加重缺血损伤
Tao Chen,Xiangrui Qiao,Lele Cheng et al.
Tao Chen et al.
It is reported that LGR4 (leucine-rich repeat domain containing G protein-coupled receptor 4) plays a crucial role in the physiological function of many organs. However, few data are available on the function and mechanism of LGR4 in myocar...
Nogo-A-Δ20/EphA4 interaction antagonizes apoptosis of neural stem cells by integrating p38 and JNK MAPK signaling [0.03%]
Nogo-A-Δ20与EphA4相互作用通过整合p38和JNK MAPK信号通路来抑制神经干细胞凋亡
Jun-Ling Wang,Wei-Guang Chen,Jia-Jia Zhang et al.
Jun-Ling Wang et al.
Nogo-A protein consists of two main extracellular domains: Nogo-66 (rat amino acid [aa] 1019-1083) and Nogo-A-Δ20 (extracellular, active 180 amino acid Nogo-A region), which serve as strong inhibitors of axon regeneration in the adult CNS ...
Exosomes with high level of miR-181c from bone marrow-derived mesenchymal stem cells inhibit inflammation and apoptosis to alleviate spinal cord injury [0.03%]
富含miR-181c的骨髓间充质干细胞外泌体通过抑制炎症和凋亡缓解脊髓损伤
Meng Zhang,Lin Wang,Sihua Huang et al.
Meng Zhang et al.
Stem cell transplantation is a promising method in the treatment of spinal cord injury (SCI). Researches have shown that stem cell-derived exosomes as well as its contents such as microRNAs contribute to the protective effects of stem cell ...
Over-expression of Fgf8 in cardiac neural crest cells leads to persistent truncus arteriosus [0.03%]
Fgf8过度表达导致心血管神经嵴细胞发育异常及永久性动脉干形成
Aijuan Tian,Shangqi Wang,Haoru Wang et al.
Aijuan Tian et al.
During cardiogenesis, the outflow tract undergoes a complicated morphogenesis, including the re-alignment of the great blood vessels, and the separation of aorta and pulmonary trunk. The deficiency of FGF8 in the morphogenesis of outflow tr...
miR-520d suppresses rapid pacing-induced apoptosis of atrial myocytes through mediation of ADAM10 [0.03%]
miR-520d通过介导ADAM10抑制快速心房起搏诱导的心房肌细胞凋亡
Qinghua Fu,Yi Tang,Jianqiang Peng et al.
Qinghua Fu et al.
MicroRNAs (miRNAs) play a key role in various pathological processes like atrial fibrillation (AF). However, the mechanisms remain unclear. Herein, this study was undertaken to probe the roles of ADAM10 and its targeting miR-520d in rapid p...
Comparison of myocardial ischemic/hypoxic staining techniques for evaluating the alleviation of exhaustive exercise-induced myocardial injury by exercise preconditioning [0.03%]
评价运动预适应缓解极限运动诱导的心肌损伤的小鼠心肌缺血/乏氧染色方法比较研究
Yue Huang,Shan- Shan Pan,Yuan-Pan Guo et al.
Yue Huang et al.
Exercise preconditioning (EP) can alleviate myocardial ischemic/hypoxic injury by inducing endogenous cardioprotection. Hematoxylin-eosin (HE), hematoxylin-basic fuchsin-picric acid (HBFP), and chromotrope-2R brilliant green (C-2R BG) stain...
miR-27a promotes osteogenic differentiation in glucocorticoid-treated human bone marrow mesenchymal stem cells by targeting PI3K [0.03%]
微RNA-27a通过靶向PI3K促进糖皮质激素处理的人骨髓间充质干细胞成骨分化
Jinshan Tang,Huaixi Yu,Yunqing Wang et al.
Jinshan Tang et al.
MicroRNA-27a (miR-27a) modulates osteogenic differentiation (OD); however, the mechanism by which it influences osteoclastic activity in the glucocorticoid (GC)-elicited osteoporotic bone is still unclear. Bone marrow was obtained from the ...