LINC01515 promotes nasopharyngeal carcinoma progression by serving as a sponge for miR-325 to up-regulate CDCA5 [0.03%]
长链非编码RNA LINC01515通过海绵吸附miR-325上调CDCA5促进鼻咽癌进展
Dan Liu,Hao Gong,Zezhang Tao et al.
Dan Liu et al.
Long non-coding RNAs (LncRNAs) have gained widespread interest and attention as vital regulators in cancer occurrence and development. Nonetheless, the functions and mechanisms of lncRNAs involved in nasopharyngeal carcinoma (NPC) are large...
Runx2 deficiency in junctional epithelium of mouse molars decreases the expressions of E-cadherin and junctional adhesion molecule 1 [0.03%]
RUNX2缺乏影响小鼠磨牙结合上皮E-钙黏着蛋白和连接粘附分子-1的表达水平
Yuan Tian,Haiyu Mu,Aiqin Wang et al.
Yuan Tian et al.
Junctional epithelium (JE) attaching to the enamel surface seals gaps around the teeth, functioning as the first line of gingival defense. Runt-related transcription factor 2 (Runx2) plays a role in epithelial cell fate, and the deficiency ...
Lyciumamide A, a dimer of phenolic amide, protects against NMDA-induced neurotoxicity and potential mechanisms in vitro [0.03%]
茋类天然产物欧指天竺葵素甲胺A对谷氨酸受体的调节作用及其机制研究
Kai Gao,Meiyou Liu,Yuan Li et al.
Kai Gao et al.
Currently, the excessive activation of N-methyl-D-aspartate receptors (NMDARs) is considered to be a crucial mechanism of brain injury. Lycium barbarum A (LyA) is a dimer of phenol amides isolated from the fruit of Lycium barbarum. Our prev...
Elevated miR-129-5p attenuates hepatic fibrosis through the NF-κB signaling pathway via PEG3 in a carbon CCl4 rat model [0.03%]
miR-129-5p通过PEG3介导的NF-κB信号通路在CCL4小鼠肝纤维化中的抗纤维化作用研究
Yuezhi Zhu,Yingbin Hu,Xianyong Cheng et al.
Yuezhi Zhu et al.
Hepatic fibrosis is a reversible scaring response to chronic liver injury. MicroRNA (miR)-129-5p might regulate fibrosis-related gene expression. This study is performed to decipher, potential of miR-129-5p to influence the progression of h...
Upregulation of CPNE3 suppresses invasion, migration and proliferation of glioblastoma cells through FAK pathway inactivation [0.03%]
CPNE3上调通过FAK途径失活抑制胶质母细胞瘤侵袭、迁移和增殖
Dijian Shi,Bo Lin,Jun Lai et al.
Dijian Shi et al.
Glioblastoma (GBM) is a deadly brain tumor with a bleak prognosis. In recent years, the copine III (CPNE3) protein was discovered to be associated to metastasis across various types of malignancies. Nevertheless, its function has not been w...
LINC00152 mediates CD8+ T-cell infiltration in gastric cancer through binding to EZH2 and regulating the CXCL9, 10/CXCR3 axis [0.03%]
LINC00152通过与EZH2结合并调节CXCL9，10/CXCR3轴介导胃癌中CD8+T细胞浸润
Jinqing Ou,Pingguang Lei,Zhenling Yang et al.
Jinqing Ou et al.
This study aimed to annotate the role of long intergenic non-coding RNA 152 (LINC00152) in CD8+ T cells mediated immune responses in gastric cancer (GC) and the underlying mechanism. LINC00152 expression levels were detected through RT-PCR....
Constitutive activation of β-catenin in odontoblasts induces aberrant pulp calcification in mouse incisors [0.03%]
牙本质小体细胞中β-连环蛋白的组成型激活诱导小鼠切齿牙髓钙化异常
Shijian Deng,Linlin Fan,Yunfei Wang et al.
Shijian Deng et al.
During dentin formation, odontoblast polarization ensures that odontoblasts directionally secrete dentin matrix protein, leading to tubular dentin formation; however, little is known about the major features and regulatory mechanisms of odo...
LncRNA TRHDE-AS1 inhibit the scar fibroblasts proliferation via miR-181a-5p/PTEN axis [0.03%]
长链非编码RNA TRHDE-AS1通过miR-181a-5p/PTEN轴抑制疤痕成纤维细胞增殖
Yanping Wei,Tingting Wang,Ningning Zhang et al.
Yanping Wei et al.
Hypertrophic scar (HS), a fibroproliferative disorder caused by abnormal wound healing after skin injury, which is characterized by excessive deposition of extracellular matrix and invasive growth of fibroblasts. Recent studies have shown t...
miR-495 reduces neuronal cell apoptosis and relieves acute spinal cord injury through inhibiting PRDM5 [0.03%]
miR-495通过抑制PRDM5减少神经元细胞凋亡并缓解急性脊髓损伤
Yan Zhang,Shanshan Wang,Hongli Li et al.
Yan Zhang et al.
This study aims to investigate the role of miR-495 in neuronal cell apoptosis after acute spinal cord injury (ASCI). The ASCI rat model was established and the Basso, Beattie, and Bresnahan (BBB) score was assessed. miR-495, PR domain conta...
SR-B1 and CD10 combined immunoprofile for differential diagnosis of metastatic clear cell renal cell carcinoma and clear cell carcinoma of the ovary [0.03%]
SR-B1和CD10联合免疫表型用于鉴别转移性透明细胞肾细胞癌和卵巢透明细胞癌的诊断价值
Teng Jiang,Xiaoli Diao,Meili Ding et al.
Teng Jiang et al.
Both clear cell renal carcinoma (ccRCC) and clear cell carcinoma of the ovary (CCOC) have a clear cytoplasmic morphological feature, hence it is difficult to identify metastatic ccRCC and CCOC by morphology alone. At present, there are no e...