Silencing of Nek2 suppresses the proliferation, migration and invasion and induces apoptosis of breast cancer cells by regulating ERK/MAPK signaling [0.03%]
Nek2沉默通过调节ERK / MAPK信号传导来抑制乳腺癌细胞的增殖，迁移，侵袭并诱导其凋亡
Zeyu Xing,Menglu Zhang,Xin Wang et al.
Zeyu Xing et al.
Breast cancer is a frequent cancer among women. The current study investigated the biological functions of Nek2 in breast cancer and its possible mechanism. The mRNA expression of Nek2 in breast epithelial cells and eight breast cancer cell...
MiR-467a-5p aggravates myocardial infarction by modulating ZEB1 expression in mice [0.03%]
小鼠miR-467a-5p通过调控ZEB1表达加重心肌梗死
Wei Huang,Yu Cao,Chenyang Chen et al.
Wei Huang et al.
Myocardial infarction (MI) is a great threat to patients all over the word. MicroRNAs (miRNAs) are a group of non-coding RNAs and can regulate initiation and progression of MI. The current research aimed to investigate the role of miR-467a-...
Zafirlukast promotes mitochondrial respiration by stimulating mitochondrial biogenesis in human bronchial epithelial cells [0.03%]
扎菲鲁卡斯特通过促进人支气管上皮细胞线粒体生物发生来提高线粒体呼吸功能
Ping Ren,Fangchao Gong,Liang Chang et al.
Ping Ren et al.
Lung diseases, including asthma, pose a serious global health issue. Loss of mitochondrial function and decreased mitochondrial biogenesis play pivotal roles in the initiation and progression of chronic lung diseases. Thus, maintaining mito...
PSMB4 inhibits cardiomyocyte apoptosis via activating NF-κB signaling pathway during myocardial ischemia/reperfusion injury [0.03%]
PSMB4通过激活NF-κB信号途径抑制心肌缺血/再灌注损伤中的心肌细胞凋亡
Chen Yang,Pengyi Yu,Fangfang Yang et al.
Chen Yang et al.
Myocardial ischemia/reperfusion (I/R) injury induces cardiomyocyte apoptosis to deteriorate heart function. Thus, how to inhibit cardiomyocyte apoptosis is the focus of recent researches. Proteasome family member PSMB4 (proteasome subunit b...
Nell-1 attenuates lipopolysaccharide-induced inflammation in human dental pulp cells [0.03%]
nell-1能够减轻脂多糖诱导的人牙髓细胞炎症反应
Rongyu Cao,Qiang Wang,Jiameng Wu et al.
Rongyu Cao et al.
Nel-like molecule type 1 (Nell-1) is a secreted protein that plays an important role in osteoinduction in multiple animal models. A previous study has suggested the anti-inflammatory effect of Nell-1 on bone inflammation inhibition. However...
Wnt5a up-regulates Periostin through CaMKII pathway to influence periodontal tissue destruction in early periodontitis [0.03%]
WNt5a通过CaMKII信号调控Periostin表达影响牙周炎早期牙周组织破坏作用机制研究
Liu Qian,Guo Shujuan,Huang Ping et al.
Liu Qian et al.
Periostin is essential for periodontal tissue integrity and homeostasis and also associated with periodontitis and periodontitis healing. This study aims to investigate the temporal and spatial expression of Periostin and Wnt5a/CaMKII in pe...
Correlation between the immune checkpoints and EMT genes proposes potential prognostic and therapeutic targets in ESCC [0.03%]
免疫检查点与EMT基因的相关性提出了食管鳞状细胞癌潜在的预后和治疗靶点
Reihaneh Alsadat Mahmoudian,Sahar Mozhgani,Mohammad Reza Abbaszadegan et al.
Reihaneh Alsadat Mahmoudian et al.
PD-1, PD-L1, CTLA-4, TIM-3, and LAG-3, crucial immune checkpoint molecules in the tumor microenvironment, identify as key targets for cancer immunotherapy. There is a correlation between immune cells and epithelial-mesenchymal transition (E...
Pregnant women with COVID-19: the placental involvement and consequences [0.03%]
妊娠期COVID-19感染与胎盘改变及影响
Shahrzad Aghaamoo,Kamran Ghods,Mojgan Rahmanian
Shahrzad Aghaamoo
SARS-CoV-2, the leading cause of COVID-19 pandemic, was detected for the first time in Wuhan. In this study, we investigated the potential undesirable maternal and feto-neonatal consequences of COVID-19, and the related pathophysiological a...
LncRNA LOC729178 acts as a sponge of miR-144-3p to mitigate cigarette smoke extract-induced inflammatory injury via regulating PHLPP2 in 16HBE cells [0.03%]
长链非编码RNA LOC729178通过调节PHLPP2充当miR-144-3p海绵以缓解香烟烟雾提取物诱导的16HBE细胞炎症损伤的作用机制研究
Meihong Wang,Yufang Liu,Yufen Zhang et al.
Meihong Wang et al.
Chronic obstructive pulmonary disease (COPD) is an inflammatory respiratory disease. Long non-coding RNAs (lncRNAs) have been implicated in the pathogenesis of COPD. In the present study, we set to investigate the role and mechanism of LOC7...
Correlation of expression of Akt1 and E2F1 and their phosphorylated forms in breast cancer patients with clinicopathological parameters [0.03%]
Akt1和E2F1及其磷酸化形式在乳腺癌患者中的表达及临床病理特征相关性分析
Shadia M Al-Bahlani,Ritu Lakhtakia,Samiya S Al-Jaaidi et al.
Shadia M Al-Bahlani et al.
Breast cancer is the leading cancer worldwide among women. Traditional clinicopathological prognostic and predictive markers need refining to improve clinical outcomes. This study explored the association between traditional clinicopatholog...