An integrated multi-omics approach for deciphering podophyllotoxin-induced nephrotoxicity via the microbiome-gut-kidney (MGK) axis based on the toxicological evidence (TEC) concept [0.03%]
基于毒理学证据（TEC）概念的鬼臼毒素肾毒性机制研究：靶器官与肠道菌群相互作用的多组学整合分析方法学建立及应用探索研究报告标题
Xiaole Guo,Yu Wang,Lei Wang et al.
Xiaole Guo et al.
Podophyllotoxin (PPT), a potent antitumor natural lignan, is clinically limited by nephrotoxicity, with the microbiome-gut-kidney (MGK) axis's role unclear. Guided by the Toxicological Evidence Chain (TEC) framework, this study used multi-o...
Icariin suppresses glycolysis in prostate cancer by upregulating ALKBH5 to mediate EARS2 m6A demethylation [0.03%]
淫羊藿苷通过上调ALKBH5介导EARS2去甲基化来抑制前列腺癌糖酵解作用
HaiFeng Ying,Ming Ruan,WenHua Zhu et al.
HaiFeng Ying et al.
Prostate cancer (PCa) is among the most frequently occurring cancers in men. Its occurrence and progression are closely related to metabolic reprogramming, with abnormally active glycolysis being a notable feature sustaining rapid prolifera...
Aucubin and Tanshinol from Bu-Shen-Huo-Xue-Fang (BSHXF) improve intervertebral disc degeneration through affecting nucleus pulposus cell [0.03%]
补肾活血方中马钱子苷和丹参素通过影响髓核细胞改善椎间盘退变作用研究
Linghui Li,Xitong Yan,Liming Zheng et al.
Linghui Li et al.
Intervertebral disc degeneration (IDD) is characterized by the abnormal synthesis of extracellular matrix (ECM) proteins, increased inflammatory cytokines, and upregulated degradative enzymes. According to the Traditional Chinese Medicine (...
Platelet-rich plasma-primed bone marrow mesenchymal stem cell-derived exosomes inhibit neuronal apoptosis and autophagy, and promote nerve regeneration via the miR-29a-3p/PTEN/PI3K/Akt/mTOR axis after spinal cord injury [0.03%]
富血小板血浆预处理的骨髓间充质干细胞衍生的外泌体通过miR-29a-3p/PTEN/PI3K/Akt/mTOR轴抑制脊髓损伤后的神经元凋亡和自噬并促进神经再生
Yao Yu,Man Fang,Cailiang Shen
Yao Yu
Both platelet-rich plasma (PRP) and exosomes derived from bone marrow mesenchymal stem cells (BMSCs) exhibit therapeutic potential for spinal cord injury (SCI). However, the combined application of PRP and BMSCs-derived exosome (PRP-primed ...
Molecular insights into induction of apoptosis and regulation of cell cycle proliferation by cycloartane triterpenoids from Dysoxylum malabaricum in breast cancer cells [0.03%]
摩洛哥马巴里木姜子三萜类化合物诱导乳腺癌细胞凋亡及调控增殖周期的分子机制研究
Vivek Kumar Sharma,Pooja Goswami,Nivedita Bhardwaj et al.
Vivek Kumar Sharma et al.
Cycloartane triterpenoids (CATT), natural compounds derived from Dysoxylum malabaricum, have substantiated promising anticancer potential, specifically against breast adenocarcinoma T-47D cells. However, the underlying mechanisms of action ...
Clinical efficacy of Fufang Zaofan Pills and their immunomodulatory effects on peripheral blood dendritic cells in individuals with lower-risk myelodysplastic syndrome [0.03%]
复方早斐片治疗低危骨髓增生异常综合征患者的临床疗效及其对外周血树突状细胞的免疫调节作用
Fei-Fei Zhang,Xiao-Yun Gao,Li-Lai Jiang et al.
Fei-Fei Zhang et al.
The aim of this study is to evaluate the clinical efficacy of Fufang Zaofan Pills in individuals diagnosed with lower-risk myelodysplastic syndrome (MDS) and to assess associated changes in peripheral blood dendritic cell (DC) levels. A coh...
Randomized Controlled Trial
Journal of molecular histology. 2026 May 20;57(3):170. DOI:10.1007/s10735-026-10822-2 2026
Therapeutic effects of Tuolitounong decoction on pyroptosis in granulomatous lobular mastitis: evidence from in vitro and in vivo models [0.03%]
托里透脓汤对肉芽肿性乳晕旁皮脂腺炎焦亡作用的体内、外研究证据分析
Xiaoguang Shi,Ximeng Zuo,Ping Sun et al.
Xiaoguang Shi et al.
Granulomatous lobular mastitis (GLM) is a chronic, refractory inflammatory condition of the breast with an unclear etiology. Emerging evidence suggests a potential role of pyroptosis in the pathogenesis of GLM. This study investigated the t...
HECTD4 in human umbilical cord mesenchymal stem cells-derived exosomes alleviates osteoclast differentiation in osteoporosis progression by suppressing RANK m6A modification via promoting METTL3 ubiquitination [0.03%]
人脐带间充质干细胞源外泌体中的HECTD4通过促进METTL3泛素化抑制RANKm6A修饰缓解骨髓炎进程中破骨细胞分化
Fang Ma,Jun Yu,Yue Qin et al.
Fang Ma et al.
Human umbilical cord mesenchymal stem cells-derived exosomes (UC-MSCs-exos) have demonstrated considerable potential in osteoporosis treatment. This study explored the underlying mechanisms of UC-MSCs-exos in this context. Osteoporosis cell...
Tanshinone IIA alleviates chronic endometritis via DRAK2 inhibition to restore mitochondrial function and suppress KDM3A-SLC2A3-driven NETs formation [0.03%]
丹参酮IIA通过抑制DRAK2来恢复线粒体功能并抑制KDM3A-SLC2A3驱动的NETs形成从而缓解慢性子宫内膜炎
Zhixiang Zou,Zikui Li,Feihong Yin et al.
Zhixiang Zou et al.
This study aimed to investigate the therapeutic potential of Tanshinone IIA (Tan-IIA) in alleviating chronic endometritis (CE), focusing on its role in mitigating mitochondrial dysfunction and suppressing neutrophil extracellular traps (NET...
Study on the synergistic efficacy and mechanism of CD24 silencing combined with trastuzumab in HER2-positive breast cancer [0.03%]
针对HER2阳性型乳癌CD24基因沉默联合赫赛汀的协同效应及机制研究
Yi Lu,Xinglu Zhou,Yue Gao et al.
Yi Lu et al.
Purpose: Reduced response to targeted therapy in human epidermal growth factor receptor 2 (HER2)-positive breast cancer underscores the need for novel therapeutic strategies and molecular targets. Cluster of differentiati...