TGF-β1 inhibits CXCL1/CXCR2 signaling pathway to alleviate neuropathic pain in a spinal nerve ligation rat model [0.03%]
TGF-β1通过抑制CXCL1/CXCR2信号通路缓解坐骨神经结扎大鼠的神经痛
Zhuang Zhou,Yue Zhang,Qianliang Wang et al.
Zhuang Zhou et al.
Neuropathic pain (NPP) is a chronic and refractory condition resulting from injury or disease of the nervous system. This study aims to elucidate the molecular mechanism by which TGF-β1 alleviates neuropathic pain through modulation of the...
The pro-apoptotic GZMB and anti-apoptotic HAX-1 and DAD-1 genes and gene proteins in human right auricular tissue affected by coronary heart disease and aortic valve stenosis: a pilot study [0.03%]
冠心病和主动脉瓣狭窄影响下的人右耳蜗组织中的促凋亡GZMB基因及其抗凋亡HAX-1和DAD-1基因与蛋白质：一项初步研究
Vitalijs Zaharovs,Mara Pilmane
Vitalijs Zaharovs
The anti-apoptotic genes DAD-1 and HAX-1 and the pro-apoptotic GZMB gene have a significant role in the regulation of apoptosis in heart tissue. However, investigation into these genes and their proteins in the pathogenesis of cardiovascula...
Araticum (Annona crassiflora) seed extract as a chemopreventive agent against prostate cancer: activation of extrinsic and intrinsic apoptotic pathways in a preclinical model [0.03%]
番樱桃属.crassiflora种子提取物作为预防前列腺癌的化学预防剂：在临床上激活外在和内在凋亡途径
Iara Lopes Lemos,Maria Josiane Macedo,Felipe Rabelo Santos et al.
Iara Lopes Lemos et al.
Prostate cancer (PCa) is among the most frequently diagnosed malignancies in aging men and remains a major public health concern, highlighting the need for effective and safe preventive strategies. Annona crassiflora Mart. seed extract (ASE...
Rebamipide attenuates LPS-induced acute lung injury in rats via modulation of macrophage polarization, PDE4B/cAMP/PKA/p-CREB and NF-κB signaling [0.03%]
雷贝马替德通过调节巨噬细胞极化、PDE4B/cAMP/PKA/p-CREB和NF-κB信号减轻脂多糖诱导的大鼠急性肺损伤
Gellan Alaa Mohamed Kamel,Asmaa S Elzaitony,Abrar Gomaa Abd Elfattah Hassan et al.
Gellan Alaa Mohamed Kamel et al.
Acute lung injury (ALI) is a severe, potentially fatal condition associated with respiratory failure and high mortality, with limited effective therapeutic options. Rebamipide (REB), a gastroprotective agent with reported antioxidant and an...
The possible therapeutic effect of platelet-rich plasma versus its derived exosomes in a hydrogen peroxide-induced depigmentation model in adult guinea pigs: a histological study [0.03%]
富血小板血浆与其衍生的外泌体在氢氧化头发色素减退模型中可能的治疗效果：组织学研究
Ayat Fadel Hussieny,Seham Kamel Abounasef,Ghada Galal Hamam et al.
Ayat Fadel Hussieny et al.
Vitiligo is a pigmentary disorder characterized by the loss of functional melanocytes, leading to depigmented skin patches and significant psychological burden. Platelet-rich plasma (PRP) and its derived exosomes have recently gained attent...
HMGB1 promotes intracranial aneurysm progression by regulating vascular smooth muscle cell phenotypic switching and ferroptosis [0.03%]
HMGB1通过调节血管平滑肌细胞表型转换和铁死亡促进颅内动脉瘤进展
Huaxin Zhu,Yanyang Zeng,Zhipeng Xiao et al.
Huaxin Zhu et al.
Phenotypic switching in vascular smooth muscle cells (VSMCs) is key to the formation and progression of intracranial aneurysms (IAs). High-mobility group box 1 (HMGB1), a damage-associated molecule, significantly influences the progression ...
Cuscuta chinensis Lam. extract alleviates ovariectomy-induced osteoporosis by inhibiting VCP-mediated METTL3 protein degradation [0.03%]
Cuscuta chinensis Lam.提取物通过抑制VCP介导的METTL3蛋白降解来缓解卵巢切除术引起的骨质疏松症
Hua Jiang,Liangyu Ma,Yong Liu et al.
Hua Jiang et al.
To investigate the therapeutic effects of Cuscuta chinensis Lam. (CCL) on ovariectomy (OVX)-induced osteoporosis (OP) and elucidate the underlying molecular mechanisms, focusing on the VCP-METTL3 axis. The bioactive components of CCL were i...
Rosmanol alleviates glycerol-induced acute kidney injury through its antioxidative and anti-apoptotic properties via ameliorating the PGC‑1α/SIRT3 signalling pathway [0.03%]
罗丝曼醇通过改善PGC-1α/SIRT3信号通路的抗氧化和抗凋亡作用缓解甘油诱导的急性肾损伤
Huan Cheng,Jing Heng,Shiyue Liao et al.
Huan Cheng et al.
Acute kidney injury (AKI) represents a fatal complication of rhabdomyolysis, which is characterised by skeletal muscle damage and necrosis. Consequently, cell contents are released into the bloodstream, eventually obstructing renal tubules,...
LncRNA TUG1 promotes hypertrophic scar formation via the miR-627/IGF1R axis [0.03%]
长链非编码RNA TUG1通过miR-627/IGF1R轴促进增生性瘢痕形成
Zeming Bai,Ziyang Han,Xiangzi Kong et al.
Zeming Bai et al.
Hypertrophic scars (HS) are fibrotic skin disorders driven by abnormal fibroblast activity. The molecular mechanisms underlying HS remain incompletely understood, particularly the role of non-coding RNAs. Expression levels of lncRNA TUG1, m...
The ameliorate effect of 18-beta glycyrrhetinic acid against cadmium-induced reproductive damage [0.03%]
甘草酸改善镉致生殖损伤的作用研究进展
Osman Çiftçi,Münevver Nazlıcan Kaplan,Özlem Özmen et al.
Osman Çiftçi et al.
This study aimed to investigate whether 18β-glycyrrhetinic acid (GA) could protect against cadmium-induced testicular damage in male rats. Twenty-four adult male Sprague Dawley rats were randomly divided into four groups (n = 6): Control, ...