Stigmasterol glucoside attenuates RANKL-induced osteoclastogenesis and bone resorption by suppressing MAPK and STAT3 signaling pathways: an integrative pharmacological study [0.03%]
整合药理学研究显示豆甾醇苷通过抑制MAPK和STAT3信号通路削弱RANKL诱导的破骨细胞生成及骨吸收
Yiwei Jiang,Zhiyu Jin,Kui Guo et al.
Yiwei Jiang et al.
Osteoporosis is a metabolic bone disease characterized by excessive osteoclast-mediated bone resorption. Stigmasterol glucoside (SG), a glycosylated phytosterol with enhanced hydrophilicity, has shown potential anti-inflammatory activities,...
Ceramide-PKCζ signaling axis mediates burn-enhanced ectopic calcification during Achilles tendon healing [0.03%]
ceramide-pkcζ信号轴介导跟腱修复过程中烧伤增强的异位钙化
Ye Ding,Xin Jiang,Xiangming Ye
Ye Ding
Burn injury frequently leads to heterotopic ossification (HO) during tendon healing, but the underlying molecular mechanisms remain poorly understood. This study investigated the role of the ceramide-protein kinase C zeta (PKCζ) signaling ...
Targeting metabolic reprogramming in HPV-associated oral squamous cell carcinoma: current advances, challenges, and clinical prospects [0.03%]
人乳头瘤病毒相关口腔鳞癌代谢重编程的靶向治疗：现有进展、挑战与临床应用前景
Anjali Kumari,Vivek Shit,Mohammad Sajid et al.
Anjali Kumari et al.
Human papillomavirus (HPV)-associated oral squamous cell carcinoma (OSCC) is increasingly investigated as a potentially distinct subset of head and neck cancers with unique molecular features. In contrast to HPV-positive oropharyngeal squam...
Downregulation of fibroblast growth factor 7 impairs endometrial receptivity and decidualisation via extracellular signal-regulated kinase and C-Jun N-Terminal kinase pathways, contributing to recurrent spontaneous abortion [0.03%]
通过细胞外信号调节激酶和c-JUN氨基末端激酶途径下调成纤维细胞生长因子7损害子宫内膜接受性及蜕膜化，导致复发性自然流产
Yaqian Lu,Ruiqing Tong,Nan Wang et al.
Yaqian Lu et al.
Recurrent spontaneous abortion (RSA) presents a significant reproductive hurdle, impacting 2-5% of women globally. Despite identification of various aetiological factors, approximately half of all cases remain unexplained. In this study, we...
Alpha-2-macroglobulin attenuates glucocorticoid-induced osteonecrosis of the femoral head by enhancing osteogenesis and antioxidant defense via the Akt/Nrf2 signaling pathway [0.03%]
α2巨球蛋白通过Akt/Nrf2信号通路增强成骨和抗氧化防御来缓解糖皮质激素诱导的股骨头坏死
Qingjian He,Xin Zheng,Boyun Huang et al.
Qingjian He et al.
Glucocorticoid-induced osteonecrosis of the femoral head (GIONFH) is featured by oxidative stress and impaired bone regeneration. Alpha-2-Macroglobulin (α-2 M) was reported to possess cytoprotective and anti-inflammatory properties, and ha...
miR-524-5p suppresses cervical cancer progression through targeting the LRP6/Wnt/β-catenin axis [0.03%]
微小核糖核酸-524-5p通过靶向低密度脂蛋白受体相关蛋白6/Wnt/β-catenin轴抑制宫颈癌进展
Min Yuan,Jialin Li,Yingying Huang et al.
Min Yuan et al.
As a leading gynecological malignancy worldwide, cervical cancer represents a major threat to female health. Further research is essential to elucidate its pathogenic mechanisms and develop effective therapeutic interventions. The objective...
Hippocampal modifications partially mediates the boosted effects of seizure induction on ASD-related behaviors in maternally separated mice, while HMGB1 and MeCP2 mRNA levels remained unchanged [0.03%]
海马修饰部分介导了惊厥诱导对母子分离小鼠自闭症相关行为的增强作用，而HMGB1和MeCP2mRNA水平保持不变
Amir Hossein Mousavi,Shima Balali-Dehkordi,Mohammad Rahimi-Madiseh et al.
Amir Hossein Mousavi et al.
Autism spectrum disorder (ASD) has some comorbidities like seizure. Maternal separation (MS) provoke ASD-related behaviors. There are discrepancies regarding effect of MS on seizure susceptibility. Structural alterations in the pyramidal la...
High MMP14 and low decorin expression correlate with disease progression and metastasis in Brazilian prostate cancer patients [0.03%]
巴西前列腺癌患者中MMP14高表达和 decorin低表达与疾病进展和转移有关
Amanda L Francelino,Fernando Terzioti,Glauco A F Vitiello et al.
Amanda L Francelino et al.
Prostate cancer (PCa) remains a highly prevalent malignancy and a leading cause of cancer-related mortality, frequently attributed to late-stage diagnosis. Matrix metalloproteinase 14 (MMP14) and Decorin (DCN) are key extracellular matrix (...
Wenyang Yishen Tongluo prescription synergizes with bone marrow mesenchymal stem cells to alleviate rheumatoid arthritis via inhibiting IL-6 [0.03%]
温阳养身通络方联合骨髓间充质干细胞抑制白介素-6缓解类风湿关节炎
Rong Su,Shiyun Yin,Lingli Gu et al.
Rong Su et al.
This study investigated the synergistic anti-arthritic effects of Wenyang Yishen Tongluo Prescription (TLP) combined with bone marrow mesenchymal stem cells (BMSCs) in rheumatoid arthritis (RA). A collagen-induced arthritis (CIA) rat model ...
Green fabrication of silver nanoparticles using Corallocarpus epigaeus (Hook.f.) Cogn. rhizome extract: phytochemical characterization and evaluation of antioxidant, antimicrobial, and anticancer activity against HT-29 cells [0.03%]
利用Corallocarpus epigaeus（Hook.f.）Cogn.根茎提取物绿色合成银纳米颗粒：植物化学成分鉴定及抗氧化、抗菌和抗HT-29癌细胞活性评价
Nagarajan Kalimuthu
Nagarajan Kalimuthu
Corallocarpus epigaeus is an ethnomedical plant with numerous bioactive phytochemicals but the potential of the plant in green nanotechnology and anticancer studies is underexplored. Phytochemical screening was conducted and AgNPs biosynthe...