Testosterone propionate maintains autophagic flux and mitochondrial integrity via regulation of the LC3B/p62/Beclin-1/mTOR axis in induced liver fibrosis [0.03%]
丙酸睾酮通过调节LC3B/p62/Beclin-1/mTOR轴维持自噬流和线粒体完整性以缓解四氯化碳所致小鼠肝纤维化
Shobhit Verma,Somya Vaishnav,Manisha Yadav et al.
Shobhit Verma et al.
The current study examines the role of testosterone and androgen deprivation in regulating mitochondrial quality control, autophagy, and apoptosis during CCl4-induced chronic liver injury. Male rats were allocated to Sham, CCl4, TP + CCl4 (...
Cell-free MSC secretome therapy ameliorates diabetic testicular injury via antioxidant mechanisms [0.03%]
细胞游离的间充质干细胞分泌组通过抗氧化机制改善糖尿病性睾丸损伤
Serbay Ozkan,Basak Isildar,Aslı Erdogan Oner et al.
Serbay Ozkan et al.
Diabetes mellitus is a metabolic disorder characterized by persistent hyperglycaemia that may impair male reproductive function. Mesenchymal stem/stromal cell-derived conditioned medium (MSC-CM) has emerged as a promising cell-free therapeu...
Comparative pre- and post-treatment effects of aqueous Zingiber officinale Lsfunction in wistar rats: insights into NF-κB, Nrf2, and caspase-3 pathways [0.03%]
姜黄素在Wistar大鼠中的治疗效果：对NF-κB、Nrf2和caspase-3途径的见解
Ezinne Obioma Onigbo,Ukoha Ukoha,Collins Nduka Esomchi et al.
Ezinne Obioma Onigbo et al.
Cadmium (Cd) is a highly toxic heavy metal that accumulates in the kidney, causing oxidative stress, inflammation, apoptosis, and renal dysfunction. Ginger (Zingiber officinale) possesses antioxidant and anti-inflammatory properties, but co...
Comparative Study
Journal of molecular histology. 2026 Jul 14;57(4):232. DOI:10.1007/s10735-026-10900-5 2026
lncRNA MEG3 and Beclin-1 as diagnostic biomarkers in serous ovarian carcinoma: molecular and immunohistochemical insights [0.03%]
长链非编码RNA MEG3和Beclin-1作为诊断生物标志物在浆液性卵巢癌中的作用：分子和免疫组化研究的见解
Ansam M Z El Desoky,Heba Mahmoud Abdelgeleel,Manar Moustafa et al.
Ansam M Z El Desoky et al.
Serous ovarian carcinoma (SOC) is frequently diagnosed at advanced stages and is associated with poor clinical outcomes, highlighting the urgent need for reliable diagnostic and prognostic biomarkers. Long non-coding RNA MEG3 and the autoph...
Porcine submandibular glands as potential salivary gland experimental models: histological, immunohistochemical, and ultrastructural characterization [0.03%]
猪颌下腺作为潜在的唾液腺实验模型：组织学、免疫组织化学和超微结构特征分析
Helena Ab&#x;Sáber Simões,Cibele Pelissari,Giovanna Florezi et al.
Helena Ab&#x;Sáber Simões et al.
Salivary glands play an essential role in oral homeostasis by producing saliva, which protects oral tissues and maintains the oral environment. Despite growing interest in porcine models for translational biomedical research, the immunophen...
Revisiting two-stage models of chemically-induced cirrhosis-associated hepatocarcinogenesis in rodents: methodological and histopathological approaches [0.03%]
从方法学和组织病理学角度重新评估化学性肝硬化相关肝细胞癌啮齿类动物两阶段模型
Antonio Rodrigues Bueno da Fonseca,Paulo Franco Cordeiro de Magalhães Junior,Luis Fernando Barbisan
Antonio Rodrigues Bueno da Fonseca
Repeated exposure to hepatotoxins such as carbon tetrachloride (CCl4), thioacetamide (TAA), or diethylnitrosamine (DEN) has been frequently used to induce fibrosis/cirrhosis in rodents. In this narrative review, we compared two-stage medium...
lncRNA MIR4435-2HG modulates the malignant progression of glioblastoma through the miR-181d-5p/MALT1/NF-κB signaling pathway [0.03%]
长链非编码RNA MIR4435-2HG通过miR-181d-5p/MALT1/NF-κB信号通路调节胶质母细胞瘤恶性进展
Pei-Sheng Chen,Liu-Fei Xu,Bo Wang et al.
Pei-Sheng Chen et al.
Glioblastoma (GBM) is a highly malignant brain tumor with a poor prognosis. Long noncoding RNAs (lncRNAs) significantly influence GBM pathogenesis. Although lncRNA MIR4435-2HG is known to promote tumorigenesis in various cancers, its regula...
Evaluation of the healing efficiency of mucoadhesive Ocimum basilicum solid lipid nano particles oral gel versus Oracure® gel in the treatment of induced buccal ulcer in rats [0.03%]
评估固定在大鼠颊黏膜上的胡椒薄荷素脂质体纳米胶粒与Oracure凝胶对诱导的颊部溃疡治疗效率的研究
Nesma Abdel Moneim,Sanaa Elzoghby,Rehab Abdelmonem et al.
Nesma Abdel Moneim et al.
Oral mucosal ulcerations are prevalent and debilitating conditions that impair functions such as mastication and speaking. Ocimum basilicum (Basil) is a plant rich in anti-inflammatory and antioxidant phytochemicals that promote healing. So...
Myricitrin as a potent inhibitor of osteoclast differentiation via RAW264.7 Cells, BMMs and ovariectomized mouse model [0.03%]
我的宁通过RAW264.7细胞、BMMs以及卵巢切除小鼠模型抑制破骨细胞分化的作用及机制研究
Jianliang Li,Yanhuai Ma,Jiale Mai et al.
Jianliang Li et al.
Background: Osteoporosis is a prevalent skeletal disorder marked by progressive bone loss and elevated fracture risk, primarily driven by excessive osteoclast-mediated bone resorption. Current therapeutic agents are limit...
GPR55 negatively regulates CD8+ intraepithelial lymphocyte migration dynamics in oral lichen planus [0.03%]
GPR55通过负向调节口腔扁平苔藓中上皮内CD8+淋巴细胞迁移动力学发挥促炎作用
Dongyang Zhou,Gang Zhou
Dongyang Zhou
Oral lichen planus (OLP) is a prevalent T-cell-mediated inflammatory disease of the human oral mucosa. Intraepithelial lymphocytes (IELs) engage in close cellular interactions with epithelial keratinocytes; however, the molecular mechanisms...