Topical hyaluronic acid serum, oral vitamin C, and their combined regimen modulate collagen-related repair indices in a sutured primary-intention rat incisional wound model [0.03%]
透明质酸钠和口服维生素C及其联合方案通过修复指标调节大鼠切口愈合模型中的胶原合成
Sara Mohamed Mokhtar Abdelrazek,Osama Yaseen Ibrahim,Mayada Saad Farrag et al.
Sara Mohamed Mokhtar Abdelrazek et al.
Healing a skin wound is a complex biological process that proceeds through three stages: inflammation, proliferation, and remodeling. Hyaluronic acid (HA) and vitamin C may help tissues heal in different but complementary ways. This study a...
Dual modulation of intracellular Ca2+ signaling by hispidulin through endoplasmic reticulum mobilization and extracellular Ca2+ entry in human breast cancer cells [0.03%]
通过内质网动员和细胞外Ca2+进入在人乳腺癌细胞中调节胞内Ca2+信号的双重机制hispidulin的作用
Nai-Yu Wang,Cheng-Chung Chang,Chiang-Ting Chou et al.
Nai-Yu Wang et al.
Hispidulin, a naturally occurring flavonoid found in various medicinal plants, exhibits anti-proliferative effects in multiple cancer models; however, its role in regulating intracellular calcium (Ca2+) signaling in human breast cancer cell...
Circ_0027446: a novel biomarker and therapeutic target to combat colorectal cancer and enhance immune response [0.03%]
circ_0027446：一种新的生物标志物和治疗靶点以对抗结直肠癌并增强免疫反应
QingYe Zhao,Chen Qin,Jie Chai et al.
QingYe Zhao et al.
Circ_0027446 has been reported to promote malignant behaviors, including proliferation, invasion, metastasis, epithelial-mesenchymal transition, and glycolytic metabolism, in several cancers; however, its expression and biological significa...
Research progresses on the regulatory roles of microRNAs in radiation-induced pulmonary fibrosis [0.03%]
微小核糖核酸调控放射性肺纤维化研究进展
Min Zhu,Haowei Li,Rui Chen et al.
Min Zhu et al.
Radiation-induced pulmonary fibrosis (RIPF) is a chronic fibrotic lung disease triggered by ionizing radiation exposure and is characterized by abnormal epithelial-mesenchymal transition (EMT), fibroblast proliferation and activation, and e...
Human chorionic membrane mesenchymal stem cell-conditioned medium activates the SOX18/MECP2 axis to protect against sepsis-induced lung injury [0.03%]
人绒毛膜基质干细胞条件培养液通过激活SOX18/MECP2轴抵抗脓毒症诱导的肺损伤
Lu Li,Fenjun Liu,Yuanyuan Chen
Lu Li
Sepsis-associated acute lung injury represents a severe complication. It is characterized by an overwhelming inflammatory response and the disruption of pulmonary barrier function, leading to high morbidity and mortality. Despite advances i...
Investigating the mechanisms of malignant progression in colorectal cancer using weighted gene co-expression network analysis and machine learning [0.03%]
利用加权基因共表达网络分析和机器学习研究结直肠癌恶性进展的机制
Song Zheng,Lei Meng,Xiaoye Fan et al.
Song Zheng et al.
Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide. Understanding the complex molecular networks that underlie this aggressive behavior is critical for developing novel diagnostic and therapeutic strategie...
Study of the potential protective efficacy of lactoferrin on indomethacin-induced gastric fundic mucosal injury in rats [0.03%]
牛乳转铁蛋白对吲哚美辛致大鼠胃体粘膜损伤保护作用的实验研究
Maha Hammady,Amany A Solaiman,Shefaa M F Elsawy et al.
Maha Hammady et al.
Gastric mucosal injury is one of the most prevalent gastrointestinal disorders. Lactoferrin, a multifunctional glycoprotein, is recognized for its potent antioxidant and anti-inflammatory properties. This study investigated the protective a...
ADSC-Exo-bFGF promotes skin wound healing and correlates with the PI3K/AKT signaling pathway activation [0.03%]
ADSC-Exo-bFGF促进皮肤伤口愈合并介导PI3K/Akt信号转导途径激活
Suoli Cheng,Fan Gong,Guiying Ma et al.
Suoli Cheng et al.
Wound healing is a complex physiological process involving a variety of tissue repair cells. Adipose-derived stem cell (ADSC)-derived exosomes have demonstrated potential in promoting wound healing. Basic fibroblast growth factor (bFGF) is ...
LncRNA TRHDE-AS1 functions as a tumor suppressor in ovarian cancer via the miR-17-5p/PIK3R1 ceRNA regulatory axis [0.03%]
长链非编码RNA TRHDE-AS1通过miR-17-5p/PIK3R1竞争性内源RNA调控轴在卵巢癌中发挥抑癌作用
Hui Liu,Chengwen Song,Dan Cheng et al.
Hui Liu et al.
This study aimed to explore the expression, biological function, and regulatory mechanism of lncRNA TRHDE‑AS1 in ovarian cancer (OC). The GEO dataset GSE119056 and the GEPIA2 database were used to assess the expression level of TRHDE-AS1 i...
Experimental investigation and network pharmacology-based analysis of the anticancer mechanisms of Fei Jin Sheng formula [0.03%]
飞劲生方抗肿瘤作用的网络药理学机制研究及实验验证
Zhen Yan,Qian Li,Jian-Xiang Chen et al.
Zhen Yan et al.
This study involves the evaluation of the Fei Jin Sheng formula (FJS), a well-established traditional Chinese medicine (TCM) treatment for non-small cell lung cancer (NSCLC), aiming to address the heightened mortality rates associated with ...