Characterization of oncohistone H2B variants in Schizosaccharomyces pombe reveals a key role of H2B monoubiquitination deficiency in genomic instability by altering gene expression [0.03%]
酿酒酵母中oncohistone H2B变异体的特征鉴定揭示了H2B单泛素化缺陷通过改变基因表达导致基因组不稳定性的关键作用
Guangchun Lu,Li Liu,Mitchell Opoku et al.
Guangchun Lu et al.
Various amino acid substitutions commonly occur at one residue of a histone in human cancers, but it remains unclear whether these histone variants have distinct oncogenic effects and mechanisms. Our previous modeling study in the fission y...
Improving Cellulosic Ethanol Production by an Engineered Yeast Consortium Displaying a Pentafunctional Mini-cellulosome [0.03%]
一种工程酵母联合体表达五功能小型半纤维素酶复合体促进纤维素乙醇生产
Xiaofei Song,Jianze Zhang,Siyu Fu et al.
Xiaofei Song et al.
As a traditional ethanol-producing microorganism, Saccharomyces cerevisiae is an ideal host for consolidated bioprocessing. However, when overloaded cellulase genes are expressed in yeast, the metabolic burden on cells may greatly affect ce...
Antifungal drug resistance in Candida glabrata: Role of cellular signaling and gene regulatory networks [0.03%]
光滑假丝酵母抗真菌药物耐药性的细胞信号转导和基因调控网络的作用
Sayan Naskar,Anjali Prajapati,Rupinder Kaur
Sayan Naskar
Nakaseomyces glabratus (Candida glabrata) is an opportunistic human fungal pathogen of high-priority that shares an ancestor with the non-pathogenic yeast Saccharomyces cerevisiae. C. glabrata causes infections of the mucosal surfaces as we...
Comparison of stress tolerance mechanisms between Saccharomyces cerevisiae and the multi-stress-tolerant Pichia kudriavzevii [0.03%]
酿酒酵母和耐多逆境的毕赤酵母胁迫耐受机制比较分析
Thasneem Banu Frousnoon,Nam Ngoc Pham,Zong-Yen Wu et al.
Thasneem Banu Frousnoon et al.
Yeasts play a vital role in both research and industrial biomanufacturing. Saccharomyces cerevisiae has been extensively utilized as a model system. However, its application is often constrained by limited tolerance to the diverse stress co...
The Saccharomyces cerevisiae ∑1278b strain is sensitive to NaCl because of mutations in its ENA1 gene [0.03%]
酿酒酵母∑1278b菌株对NaCl敏感是由于其ENA1基因发生突变所致
David Engelberg,Alexey Baskin,Shelly Ben Zaken et al.
David Engelberg et al.
Most laboratory strains of the yeast Saccharomyces cerevisiae are incapable to invade agar, to form large colonies (mats), and to develop filament-like structures (pseudohyphae). A prominent strain that manifests these morphologies is ∑127...
Optimization of the culture medium for an iron-sensitive oleaginous yeast, Rhodotorula toruloides NBRC 0559, through functional iron-deficiency [0.03%]
通过功能缺铁筛选法优化铁抑制性产油红酵母（Rhodotorula toruloides NBRC 0559）培养基
Minsung Kim,Yuri Tanaka,Hiroyuki Kajiura et al.
Minsung Kim et al.
A complete iron-deficiency in iron-sensitive oleaginous yeast showed insufficient biomass, resulting in a lower lipid amount, although lipid accumulation was greater compared to deficiency in other ions. In this study, the effect of functio...
Miriam Kuzman,Özge Ata,Diethard Mattanovich
Miriam Kuzman
Single carbon (C1) molecules are considered as valuable substrates for biotechnology, as they serve as intermediates of carbon dioxide recycling, and enable bio-based production of a plethora of substances of our daily use without relying o...
Metabolic engineering of yeast to efficiently synthesize heme and hemoproteins: recent advance and prospects [0.03%]
用于高效合成血红素和含血红素蛋白的酵母代谢工程学：最新进展及前景展望
Haibo Yu,Yunpeng Wang,Yijie Wang et al.
Haibo Yu et al.
Owing to the potential for commercialization, the recombinant production of hemoproteins has been heavily investigated. Yeast is a superior host for the synthesis of eukaryotic hemoproteins with optimal pathway to facilitate heme delivery a...
Regulation of meiotic gene expression is functional in the human fungal pathogen Candida glabrata [0.03%]
模式真菌病原体毕赤酵母中对 meiotic 基因表达调控的功能分析
Natalia Klimova,Cindy Ngov,Frédéric Devaux et al.
Natalia Klimova et al.
The human fungal pathogen Candida glabrata is closely related to the budding yeast Saccharomyces cerevisiae. The sexual cycle in S. cerevisiae has been extensively characterized. Haploid cells 'a' and alpha secrete pheromones involved in ma...
The physiology of an engineered Saccharomyces cerevisiae strain that carries both an improved glycerol-3-phosphate and the synthetic dihydroxyacetone pathway for glycerol utilization [0.03%]
携带改进的甘油-3-磷酸和合成二羟基乙酸途径以利用甘油的工程酵母菌株生理学研究
A Perpelea,F M Bahia,J Xiberras et al.
A Perpelea et al.
Our laboratory previously established variants of the S. cerevisiae strain CEN.PK113-1A able to grow in synthetic glycerol medium. One approach focused on improving the endogenous L-glycerol 3-phosphate (G3P) pathway, while a second approac...