Dariusz R Kutyna,Sylvie Dequin,Amparo Querol et al.
Dariusz R Kutyna et al.
Unravelling the genomic blueprint of a reference laboratory strain of the yeast Saccharomyces cerevisiae 30 years ago opened a new era in understanding yeast biology. Since then, genomics has transformed our ability to study, adapt, improve...
Overexpression of the MAPK Transcription Factor Gene MSS11 Enhances Ethanol Biosynthesis in Saccharomyces cerevisiae via Coordinated Metabolic and Stress-Response Reprogramming [0.03%]
MAPK转录因子基因MSS11过表达通过协调代谢和压力响应的重编程增强乙醇生物合成
Xu Qiu,Yangyang Liu,Aili Zhang
Xu Qiu
Bioethanol is a pivotal sustainable alternative to fossil fuels. Saccharomyces cerevisiae is the primary microorganism for its industrial production. Enhancing the fermentative performance of S. cerevisiae is crucial for sustainable bioetha...
Modelling Human Proteostasis and Organelle Homeostasis Disorders in Yeast and Its Application in Drug Discovery [0.03%]
用于酵母的模式细胞生物学及其在药物研发中的应用
Anh V Do,Memoona Zahra,Alan L Munn
Anh V Do
Disruptions in cellular homeostasis and proteostasis are central to many human diseases, yet direct mechanistic investigation in human systems remains constrained by biological complexity and ethical limitations. Therefore, researchers have...
The yeast genome at 30: A blueprint written by a collaborative and consilient community [0.03%]
酵母基因组研究三十载——通力协作与多学科交叉的典范
Isak S Pretorius,John P Morrissey
Isak S Pretorius
Completion of the Saccharomyces cerevisiae genome sequence three decades ago marked a defining moment in eukaryotic genomics. Beyond a technical milestone, it established a shared reference that transformed how yeast biology is studied, int...
Clearing Candida biofilms using combined antimicrobial Sophorolipids with Amphotericin B and Itraconazole [0.03%]
联合使用两性霉素B和伊曲康唑的新型抗真菌 sophorolipid 复合物破坏白色念珠菌生物被膜
L A Channa B Jayasekara,Kwanrutai Watchaputi,Jirayut Euanorasetr et al.
L A Channa B Jayasekara et al.
Candida albicans biofilms present a major clinical challenge due to their resistance to conventional antifungal therapies. Sophorolipids (SLs), glycolipid biosurfactants produced by Starmerella riodocensis, have emerged as promising antifun...
K L Riddle,R Sterling,M Hudson et al.
K L Riddle et al.
This article explores the challenges and opportunities associated with benefit sharing and genetic resources in the context of microorganisms, with a particular focus on understanding Indigenous rights and perspectives. It examines traditio...
Optimisation and scale up of L-malic acid production from methanol by the methylotrophic yeast Ogataea polymorpha [0.03%]
来自甲醇的L-苹果酸生产优化及放大研究(Ogataea polymorpha菌)
Alessandra Mauri,Miroslava Yovcheva,Philipp Demling et al.
Alessandra Mauri et al.
Industrial production of malic acid remains dependent on fossil resources or, when performed microbiologically, on sugar-based feedstocks. Both routes come with caveats, generating emissions and competing with food supply. The use of CO₂-d...
A CRISPR/Cas9-based genome-editing platform enabling efficient and precise gene replacement in Lipomyces starkeyi [0.03%]
一个基于CRISPR / Cas9的基因组编辑平台，可实现Lipomyces starkeyi中高效和精确的基因替换
Rikako Sato,Kaito Maruyama,Satoshi Ara et al.
Rikako Sato et al.
Lipomyces starkeyi is a promising oleaginous yeast with industrial potential. However, its genome engineering remains constrained by low gene-targeting efficiency and the requirement for long homologous regions. Herein, we established a CRI...
Evelyn Sattlegger,Anja H Schiemann
Evelyn Sattlegger
For many human diseases and disorders, the underlying molecular mechanism often remains poorly understood, limiting progress in developing effective targeted therapies and diagnostic tools. To fill this gap in knowledge, surrogate systems a...
Engineering Yeast for Sustainable Bioproduction of Tryptophan-Derived Aromatic Compounds [0.03%]
工程酵母可持续生物生产色氨酸派生物芳香化合物
Baode Sun,Xinqi Xie,Axayacatl González et al.
Baode Sun et al.
Aromatic compounds are a diverse group of bioactive molecules with broad applications in the polymer, food, feed, cosmetic, and pharmaceutical industries. To address climate change and the depletion of fossil resources, there is growing int...