G Brach,J Schacherer
G Brach
Over the past three decades, Saccharomyces cerevisiae has gone from being the first eukaryote to have its genome fully sequenced to one of the most studied biological systems. Advances in sequencing technologies, functional genomics, and po...
Reprogramming a Hgt-family Kluyveromyces marxianus sugar transporter by site-directed mutagenesis to enable co-consumption of glucose and xylose [0.03%]
通过定向突变重构酿酒酵母马克斯克鲁维酵母Hgt家族糖转运蛋白以同时利用葡萄糖和木糖
Lorena Donzella,Carlos Belloch-Molina,John P Morrissey et al.
Lorena Donzella et al.
Efficient utilization of lignocellulosic hydrolysates in yeast-based biorefineries requires simultaneous consumption of glucose and xylose, which is often limited by preferential glucose uptake. In Kluyveromyces marxianus, we kinetically ch...
Adaptive laboratory evolution of maltose utilisation in wild Irish isolates of Saccharomyces eubayanus [0.03%]
麦芽糖利用的适应性实验室进化——以爱尔兰野生雪华葡萄酵母(Saccharomyces eubayanus)分离株为材料的研究
Sean Bergin,Jillian Scully,Conor Hession et al.
Sean Bergin et al.
The first European isolates of S. eubayanus were discovered in Ireland in 2022 and belong to the same clade as the S. eubayanus parent of the hybrid lager yeast S. pastorianus. Here, we report the isolation of ten additional Irish strains a...
Replicative age differentially predicts metabolic competence across industrial yeasts at single-cell resolution [0.03%]
replicative 年龄在工业酵母单细胞分辨率代谢能力上的不同预测能力
Marco Eigenfeld,Elisabeth Zach,Ann-Kathrin Bürkle et al.
Marco Eigenfeld et al.
In industrial yeast fermentations, population-level viability assays routinely report healthy cultures even as aged, metabolically compromised mother-cell subpopulations go undetected. Replicative age contributes to this hidden heterogeneit...
Life beyond 6,000 genes: From sequence to synthesis in a post-genomics era [0.03%]
后基因组时代的生命体：从序列到合成研究超六千个基因的生物体
Roy S K Walker,Edward Archer,Paige Erpf et al.
Roy S K Walker et al.
The publication of the Saccharomyces cerevisiae genome sequence thirty years ago marked a defining shift in modern biology, establishing yeast as the first fully sequenced eukaryotic model cell. Access to a complete reference genome has cat...
De novo Genome Assembly of a Native Saccharomyces cerevisiae Strain Isolated from Spontaneous Fermentation of Vineyard Must in the Atacama Desert (Chile) [0.03%]
从阿塔卡马沙漠葡萄汁自发发酵中分离的土著酿酒酵母菌株的从头基因组组装
Héctor Aguayo-Cumplido,Michelle Cifras,Marcelo Lanino et al.
Héctor Aguayo-Cumplido et al.
In this work, we investigated the genomic and phenotypic basis of stress tolerance in the native Saccharomyces cerevisiae strain M6, isolated from spontaneously fermenting must at a vineyard located in Atacama Desert, through a de novo hybr...
Transcriptional regulation: Efficient genetic engineering tools for non-conventional yeasts [0.03%]
转录调控：非传统酵母菌的高效基因工程技术
Shabana Haneef,Yongjin J Zhou,Fan Bai
Shabana Haneef
Non-conventional yeasts are recognized as valuable hosts for producing biofuels, pharmaceuticals, and other high-value chemicals, owing to their diverse physiological traits, ability to utilize various substrates, and greater tolerance to e...
Cysteine, methionine, and pantothenic acid remodel the Saccharomyces cerevisiae transcriptome and volatile sulfur compound metabolome during alcoholic fermentation [0.03%]
半胱氨酸、蛋氨酸和泛酸重编程酿酒酵母转录组和酒精发酵期间的挥发性硫化物代谢产物图谱
Rafael Jiménez-Lorenzo,James D Duncan,Valérie Nolleau et al.
Rafael Jiménez-Lorenzo et al.
Yeast nitrogen and vitamin nutrition are fundamental levers for managing wine quality, yet the specific mechanisms linking nutrient availability to sulfur aroma formation remain poorly understood. This study explored the impact of methionin...
Katherine D Mueller,Soo Chan Lee
Katherine D Mueller
The human gastrointestinal (GI) microbiota has come to be recognized as a modulator of health. However, interest in fungi and their function as members of the microbiota has lagged behind interest in bacteria. Despite the lack of historical...
Ryoya Tanahashi,Hiroshi Takagi,Akira Nishimura
Ryoya Tanahashi
The yeast Saccharomyces cerevisiae coordinates growth, metabolism, and stress adaptation through signaling pathways that respond to changes in nutrient availability. Classical nutrient-sensing systems, including the cAMP-protein kinase A (P...