A CRISPR/Cas9-based genome-editing platform enabling efficient and precise gene replacement in Lipomyces starkeyi [0.03%]
一个基于CRISPR / Cas9的基因组编辑平台，可实现Lipomyces starkeyi中高效和精确的基因替换
Rikako Sato,Kaito Maruyama,Satoshi Ara et al.
Rikako Sato et al.
Lipomyces starkeyi is a promising oleaginous yeast with industrial potential. However, its genome engineering remains constrained by low gene-targeting efficiency and the requirement for long homologous regions. Herein, we established a CRI...
Evelyn Sattlegger,Anja H Schiemann
Evelyn Sattlegger
For many human diseases and disorders, the underlying molecular mechanism often remains poorly understood, limiting progress in developing effective targeted therapies and diagnostic tools. To fill this gap in knowledge, surrogate systems a...
Engineering Yeast for Sustainable Bioproduction of Tryptophan-Derived Aromatic Compounds [0.03%]
工程酵母可持续生物生产色氨酸派生物芳香化合物
Baode Sun,Xinqi Xie,Axayacatl González et al.
Baode Sun et al.
Aromatic compounds are a diverse group of bioactive molecules with broad applications in the polymer, food, feed, cosmetic, and pharmaceutical industries. To address climate change and the depletion of fossil resources, there is growing int...
MFS-transporter Flr1 is a major drug-efflux transporter in Saccharomyces cerevisiae ascospores [0.03%]
酿酒酵母有性孢子的主要抗药性外排蛋白为MFS转运蛋白Flr1
Arina M Adamovich,Dmitry A Knorre,Kseniia V Galkina
Arina M Adamovich
In fungi, spores represent a highly resilient stage of the life cycle, characterized by low metabolic activity that confers resistance to xenobiotics. However, as soon as spores start germination, they become vulnerable to low-molecular-wei...
From Discovery to Application: Twenty Years of Meyerozyma caribbica [0.03%]
从发现到应用——Meyerozyma caribbica研究的二十年进展
Elisângela de Souza Miranda Muynarsk,Angela Alves Dos Santos,Cristina Link Rüntzel et al.
Elisângela de Souza Miranda Muynarsk et al.
Over the past two decades, Meyerozyma caribbica has been identified as a metabolically versatile and ecologically adaptable yeast with significant relevance to biotechnology, agriculture, environmental remediation, and food applications. Si...
Optimising Carbon-to-Nitrogen Ratios for Enhanced Antimicrobial Sophorolipid Production in Starmerella riodocensis GT-SL1R [0.03%]
优化碳氮比以增强Starmerella riodocensis GT-SL1R中抗菌型 sophorolipids的生产
Sirawich Sapsirisuk,Pattanan Songdech,Kwanrutai Watchaputi et al.
Sirawich Sapsirisuk et al.
Sophorolipids (SLs) are promising biosurfactants with diverse industrial and biomedical applications; however, optimising their production efficiency remains a challenge. This study investigates the effect of carbon-to-nitrogen (C/N) ratios...
Construction of a reference genome for Starmerella batistae and annotation of Starmerella species reveal an unexpected evolutionary relationship with Schizosaccharomyces pombe and suggest an alternative enzymatic route for sophorolipid production [0.03%]
葡萄糖苷酶突变株Starmerella batistae参考基因组的构建及Starmerella物种的注释揭示了其与裂殖酵母Schizosaccharomyces pombe出乎意料的进化关系，并为鼠李糖脂生物合成提出了一个替代途径
Soukaina Timouma,Alistair Hanak,Laura Natalia Balarezo Cisneros et al.
Soukaina Timouma et al.
The Starmerella clade is known for displaying osmotolerant and acidophilic traits from their association with bees. Several species in this genus can produce sophorolipids, which are commercially produced as biosurfactants. Here, we isolate...
Evaluating Canadian Yeast Strains for Novel New-Make Spirit Applications [0.03%]
评估加拿大酵母菌株在新型新蒸馏酒应用中的效果
R Alexander Marr,P Cartes,B Cook et al.
R Alexander Marr et al.
Whisky is an alcoholic beverage derived from fermented grain mash that is distilled into "new make spirit" before maturing in barrels. While most research on whisky innovation has focused on raw materials or maturation, yeast strain selecti...
Thiol groups are determinant for overcoming acetic acid and pH stress in wine and beer fermentation-derived Saccharomyces cerevisiae strains [0.03%]
巯基决定葡萄酒和啤酒发酵衍生的酿酒酵母菌株克服醋酸和pH胁迫的能力
Anahit Shirvanyan,Angela Primavera,Nicoletta Guaragnella et al.
Anahit Shirvanyan et al.
Acetic acid (AA), a natural by-product of ethanol fermentation in yeast cells, is widely present in lignocellulosic hydrolysate as a fermentation inhibitor. Thus, gaining insight into the molecular mechanisms of AA tolerance in yeast is par...
High-Throughput Yeast Engineering in Biofoundries: Toward Autonomous and Scalable Synthetic Biology [0.03%]
酵母生物铸造厂的高通量工程：迈向自主和可扩展的合成生物学
J P O Martinez,R E Speight
J P O Martinez
High-throughput yeast engineering is being transformed by biofoundries that integrate automation, artificial intelligence (AI), and standardised workflows. This review examines how these facilities accelerate strain development through the ...