JAK2/STAT3 involves oxidative stress-induced cell injury in N2a cells and a rat MCAO model [0.03%]
Janus激活 kinase 2/信号转导子和转录活化蛋白 3在氧化应激诱导的神经元损伤中的作用及机制研究
Yan Sun,Man Cheng,Xiaoshan Liang et al.
Yan Sun et al.
Purpose: In this study, we sought to test the hypothesis that oxidative stress injury in ischemic brains and H2O2-treated mouse neuroblastoma Neuro-2a cells (N2a) was related to STAT3 activation.Materials and methods: Rat middle cerebral ar...
Xianghe Meng,Yingjiao Li,Yajun Lian et al.
Xianghe Meng et al.
Purpose: Krabbe disease (KD) or globoid cell leukodystrophy is an autosomal recessive lysosomal disorder caused by a lack of the lysosomal enzyme galactocerebrosidase (GALC) because of mutations in GALC. Patients with KD exhibit a wide spec...
Skin damage in a patient with lipid storage myopathy with a novel ETFDH mutation responsive to riboflavin [0.03%]
一例新型ETFDH基因突变的脂质贮积性肌病伴皮肤损害并辅酶R治疗有效的病例报告
Hongliang Xu,Xin Chen,Yajun Lian et al.
Hongliang Xu et al.
Background: Recessive mutations in ETFDH gene have been associated with Multiple Acyl-CoA dehydrogenase deficiency (MADD). The late-onset MADD is often muscle involved, presenting with lipid storage myopathy (LSM). The symptoms of LSM were ...
Aging protects rat cortical slices against to oxygen-glucose deprivation induced damage [0.03%]
老化对大脑皮层切片中氧-葡萄糖剥夺损伤的保护作用
Zulfiye Gul,Celaleddin Demircan,Deniz Bagdas et al.
Zulfiye Gul et al.
Objective: In present study, we aimed to clarify effect of aging on the susceptibility of brain tissue to neurodegeneration induced by ischemia.Methods: Damage induced by oxygen-glucose deprivation (OGD) followed by reoxygenation (REO) were...
Prevention and treatment of temporal lobe epilepsy: lessons from hepatitis B story! [0.03%]
乙肝故事里看颞叶癫痫的防治！
Ali A Asadi-Pooya,Luca Bartolini
Ali A Asadi-Pooya
Temporal lobe epilepsy (TLE) is the most common type of drug-resistant epilepsy and hippocampal sclerosis (HS) is the most common pathological substrate of TLE. Considering the significant consequences of uncontrolled seizures (e.g. increas...
Hai Yang,Wenjuan Hong,Le Chen et al.
Hai Yang et al.
Purpose: Depression, which affects about 52% of Alzheimer's disease (AD) patients, can worsen cognitive impairment and increase mortality and suicide rates. We hope to provide clinical evidence for the prevention and treatment of depression...
Potential of ovine Wharton jelly derived mesenchymal stem cells to transdifferentiate into neuronal phenotype for application in neuroregenerative therapy [0.03%]
来源于羊胎盘华通胶间充质干细胞向神经元表型转分化的潜能及其在神经再生治疗中的应用价值
Lija Satheesan,Eswari Soundian,Vijayarani Kumanan et al.
Lija Satheesan et al.
Introduction: The transdifferentiation potential of mesenchymal stem cells (MSCs) is not limited to mesodermal derivatives but also to other cell types such as neuronal cells under appropriate cell culture conditions.Materials and methods: ...
Subdural hematoma from an acquired dural arteriovenous fistula following external ventricular drain placement for subarachnoid hemorrhage [0.03%]
外伤性硬脑膜动静脉瘘致脑室外引流术后亚急性硬膜下血肿一例报告
Panagiotis Kerezoudis,Thomas J Sorenson,Joseph R Kapurch et al.
Panagiotis Kerezoudis et al.
Objective: Intracranial dural arteriovenous fistulas represent pathological connections between dural arteries and dural veins, dural sinuses or meningeal veins in the absence of an intervening capillary bed. They are thought to be acquired...
Identification of dysregulated genes and pathways of different brain regions in Alzheimer's disease [0.03%]
阿尔茨海默病不同脑区的异常表达基因与信号通路识别
Yaping Wang,Zhiyun Wang
Yaping Wang
Background: Alzheimer's disease (AD) is a degenerative neurologic disease. The study aimed to identify the key differentially expressed genes (DEGs) and pathways in AD pathogenesis and obtain potential biomarkers in AD diagnosis.Methods: An...
Homer1a protects against neuronal injury via PI3K/AKT/mTOR signaling pathway [0.03%]
Homer1a通过PI3K/Akt/m TOR信号通路保护神经元免受损伤
Yuan Wang,MingMing Zhao,Lv Shang et al.
Yuan Wang et al.
Purpose: Homer1a is a member of the post-synaptic density protein family that plays an important role in neuronal synaptic activity and is extensively involved in neurological disorders. The aim of this study is to investigate the role of H...