A novel machine learning-based method to quantify the effect of transcranial direct current stimulation on opioid users [0.03%]
一种基于机器学习的方法量化经颅直流电刺激对阿片类药物使用者的影响的效果的新方法
Fatemeh Kazemzadeh,Sepideh Jabbari,Bahram Perseh et al.
Fatemeh Kazemzadeh et al.
Background: Opioid addiction is a major public health concern, associated with numerous health and social problems. Conventional diagnostic methods for addiction have notable limitations, highlighting the need for alterna...
Dual-Feature Cross-Fusion Network for Precise Brain Tumor Classification: A Neurocomputational Approach [0.03%]
基于双特征交叉融合的精确诊断脑肿瘤分类方法研究
Muthalakshmi M,Surya G,Mininath Bendre et al.
Muthalakshmi M et al.
Brain tumors represent a significant neurological challenge, affecting individuals across all age groups. Accurate and timely diagnosis of tumor types is critical for effective treatment planning. Magnetic Resonance Imaging (MRI) remains a ...
Research Progress on Histone Lactylation Modification in Ischemic Stroke: Mechanisms and Therapeutic Potential [0.03%]
缺血性卒中组蛋白乳酰化修饰研究进展：机制与治疗潜力探讨
Wang Tingting,Yushan Chen,Wang Shuangshuang
Wang Tingting
Ischemic stroke (IS) is a leading cause of death and disability worldwide, with a complex pathogenesis involving neuroinflammation, oxidative stress, and disruption of the blood-brain barrier. Recent research has brought histone lactylation...
Analysis of the clinical effects of the transvertebral anterior approach for contralateral C7 nerve translocation in treating central upper limb paralysis: a retrospective study [0.03%]
颈椎椎间前路联合C7神经根移位治疗中枢性上肢瘫的临床疗效分析：回顾性研究
Shichang Guo,Bo Zhang,Xiaohui Liu et al.
Shichang Guo et al.
Objective: To investigate the clinical efficacy of the transvertebral anterior approach to contralateral C7 nerve translocation for treating patients with upper limb spastic hemiparesis caused by central nerve injury. ...
L-3n-butylphthalide maintains BBB Permeability and attenuates cerebral ischemia-reperfusion injury in rats by increasing PGC-1α levels [0.03%]
L-3丁基苯酞通过提高PGC-1α水平维持血脑屏障通透性并减轻大鼠缺血再灌注损伤
Yu Wang,Xiangsong Shi,Liling Wu et al.
Yu Wang et al.
Aim: The aim of the present study was to investigate the possible mechanisms of DL-3-n-butylphthalide (NBP) in maintaining the stability of the blood-brain barrier (BBB) and attenuating cerebral ischemia-reperfusion injur...
Hippocampal neural stem cells in Alzheimer's disease: bridging neurogenesis, extracellular vesicles, and multimodal therapeutic paradigms [0.03%]
阿尔茨海默病中的海马神经干细胞：连接神经发生、细胞外囊泡和多模式治疗范式
Ruoyu Li,Wenrui Xiong,Chong Sun
Ruoyu Li
Alzheimer's disease (AD) presents a formidable challenge in neurodegenerative medicine because of its complex pathophysiology and the absence of effective disease-modifying therapies. Emerging evidence suggests that impaired adult hippocamp...
Immunohistochemical characterisation of dopaminergic and cholinergic alterations in the prefrontal cortex and hippocampus of MPTP-treated marmosets [0.03%]
美乐帕罗诱导的绒猴前额叶皮质和海马体多巴胺能和胆碱能改变的免疫组化表征
Sanaa Khosla
Sanaa Khosla
Motor symptoms traditionally characterise Parkinson's disease (PD), but cognitive dysfunctions have recently emerged as significant non-motor features. While dopamine deficiency in the substantia nigra primarily causes PD, recent evidence i...
Serum Tyrosine Associates with Increased CSF Aβ42, Reduced Aβ Deposition, and Cognitive Improvement in MCI: Modulation by Confounding Factors [0.03%]
血清酪氨酸与脑脊液Aβ42增加、脑内Aβ沉积减少及轻度认知障碍患者的认知改善有关：混杂因素的调节作用
Shahad Mohammed Dhiaa Younis,Abdulkareem Shareef,Ashok Kumar Bishoyi et al.
Shahad Mohammed Dhiaa Younis et al.
Tyrosine, a precursor to dopamine, norepinephrine, and epinephrine, has shown mixed results in cognitive impairment studies, suggesting a complex role in mild cognitive impairment (MCI). This study is the first to explore its relationship w...
Thymic stromal lymphopoietin modification gates chronic pain via regulation of transient receptor potential vanilloid type 1-caspase1 [0.03%]
胸腺基质淋巴细胞生成素通过调节瞬时受体电位香草酸型1-半胱天冬酶1介导慢性疼痛
Ying-Yi Lu,Chun-Ching Lu,Hung-Pei Tsai et al.
Ying-Yi Lu et al.
Aim: Given that depletion of thymic stromal lymphopoietin (TSLP) signals is a potential therapeutic option to relieve chronic pain, in this study, we aimed to explore the role of TSLP in regulation of chronic pain and cla...
Vagus Nerve Stimulation Ameliorates Learning-Memory Deficits and Suppresses Neuronal Apoptosis via the ERK/CREB/BDNF Signaling Pathway in Epileptic Rats [0.03%]
迷走神经刺激通过ERK/CREB/BDNF信号通路改善癫痫大鼠学习记忆障碍并抑制神经元凋亡
Yao Lu,Yang Li,Wenhao Su et al.
Yao Lu et al.
Purpose: This study aimed to evaluate the impact of vagus nerve stimulation （VNS） on learning, memory, and neuronal apoptosis in epileptic rats, and to investigate the involvement of the ERK/CREB/BDNF signaling pathway. ...