Key challenges in traumatic brain injury treatment: integrated mechanisms, translational animal models, and advanced drug delivery systems [0.03%]
创伤性脑损伤治疗的关键挑战：集成机制、转化动物模型和先进的药物递送系统
Junzhe Yang,Yuanyuan Zhang,Jingzhe Wang et al.
Junzhe Yang et al.
Aim: To synthesize the mechanistic cascade of secondary injury after traumatic brain injury (TBI) and evaluate emeging drug delivery systems (DSS)in the context of translational therapeutic development. Methods: This re...
Language-related functional connectivity in post-stroke aphasia: preliminary findings from a graph-theoretical and interpretable machine learning study [0.03%]
基于图论和可解释机器学习的卒中后失语症的语言功能连接的初步研究发现
Ngoc Thanh Hoang,Christof Karmonik,Thishuli Walpola et al.
Ngoc Thanh Hoang et al.
Purpose: To have an insight into language-related functional connectivity in post-stroke aphasia (PSA) from graph theory measurements when performing an ability-matched auditory-verbal task fMRI. ...
Summary of the best evidence for frailty management in patients with ischemic stroke during the rehabilitation period [0.03%]
缺血性卒中恢复期衰弱管理的最佳证据总结
Shuting Liu,Xiaokang Wang,Zhe Zhang
Shuting Liu
Background To retrieve and summarize the best evidence for frailty management in patients with ischemic stroke during the rehabilitation period, providing reference for clinical practice. Methods The system searches for literature on stroke...
Integrating neurotrophic and anti-inflammatory pathways: press-needle acupuncture as a multi-target therapy for adolescent depression [0.03%]
神经营养和抗炎通道的整合：揿针治疗青少年抑郁的多靶点机制研究
Haomin Zhang,Yufeng Rong,Ruirui Ning et al.
Haomin Zhang et al.
Background: Press needle therapy, may alleviate depressive-like behaviors. Methods: Male rats were randomly allocated into four groups ...
Modulation of the HMGB1/TLR4 Pathway by Montelukast in PTZ-Induced Epilepsy: Alleviating Neuroinflammatory Oxidative Stress and Seizure Severity [0.03%]
蒙特鲁卡斯特通过调节HMGB1/TLR4通路缓解戊四唑诱导的癫痫小鼠模型的神经炎症和氧化应激反应及发作严重程度的研究
Aysha Bano,Nidhi Nidhi,Mohd Samim et al.
Aysha Bano et al.
Epilepsy is a multifactorial neurological disorder, frequently associated with neuroinflammatory processes that contribute to the persistence of recurrent seizures. Conventional antiepileptic drugs (AEDs) often fail to achieve complete seiz...
High MAP3K6 Expression in Spinal Cord Injury Tissues Enhances Neuronal Apoptosis: Insights from Multi-Omics Data Integrating WGCNA, Machine Learning, and Experimental Validation [0.03%]
MAP3K6高表达通过促进神经元凋亡加剧脊髓损伤：基于多组学数据的WGCNA、机器学习和实验验证研究
Yanbing Liu,Zhao Liu,Yiqing Shi
Yanbing Liu
Spinal cord injury (SCI) is a major global health issue with severe complications, yet effective biomarkers remain elusive. We analyzed the GSE226238 dataset from the GEO database and identified 4,621 differentially expressed genes (DEGs) b...
Insulin resistance increases stroke risk: a cross-sectional study from NHANES 1999-2018 and a Mendelian randomization study [0.03%]
胰岛素抵抗增加卒中风险：来自NHANES 1999-2018横断面研究与孟德尔随机化研究的证据
Yaxian Hu,Fei Zou,Zhen Zhou et al.
Yaxian Hu et al.
Background: Existing evidence suggested a relevance between insulin resistance (IR) and stroke, but further confirmation is needed. Research priorities encompass large sample size, stratified analysis, advanced IR index, ...
Rising mortality and post-COVID shifts due to stroke in adults with dyslipidemia in the U.S. from 1999 to 2023: analysis of the CDC WONDER database [0.03%]
美国1999年至2023年血脂异常成人中由于中风导致的死亡率上升及新冠疫情后的变化：对CDC WONDER数据库的分析
Maryam Saghir,Muhammad Affan,Abdullah Masood Ahmed et al.
Maryam Saghir et al.
Introduction: Stroke is a leading cause of mortality and long-term disability in the U.S. and worldwide. Among its key modifiable risk factors, dyslipidemia plays a significant role by accelerating atherosclerosis and imp...
Efficacy, safety and dosing of intravenous alteplase administered beyond 4.5 hours for ischemic stroke: systematic review and meta-analysis [0.03%]
超时间窗静脉内给予阿替普酶治疗缺血性卒中的疗效、安全性和剂量：系统评价和荟萃分析
Bassel Alrabadi,Yousef Alghzawi,Hasan I Mater et al.
Bassel Alrabadi et al.
Aim: To evaluate the efficacy, safety, and dosing of intravenous alteplase administered beyond the conventional 4.5-hour therapeutic window in adults with acute ischemic stroke. ...
The correlation between YTHDF1 gene polymorphism and cognitive dysfunction after radiotherapy for glioma [0.03%]
YTHDF1基因多态性与胶质瘤放疗后认知功能障碍的相关性研究
Huanfeng Zhu,Xiyun Shi,Dan Zong et al.
Huanfeng Zhu et al.
Background: Gliomas are the most common primary malignant tumors of the central nervous system. Mounting evidence highlights the crucial role of YTH N6-methyladenosine RNA binding protein 1 (YTHDF1) in glioma treatment re...