Mucosal immunity and protection against HIV/SIV infection: strategies and challenges for vaccine design [0.03%]
粘膜免疫与预防HIV/SIV感染：疫苗设计的策略和挑战
Thorsten Demberg,Marjorie Robert-Guroff
Thorsten Demberg
To date, most HIV vaccine strategies have focused on parenteral immunization and systemic immunity. These approaches have not yielded the efficacious HIV vaccine urgently needed to control the AIDS pandemic. As HIV is primarily mucosally tr...
Genevieve Inchauspe,Guillaume Bach,Perrine Martin et al.
Genevieve Inchauspe et al.
Adrian Bot
Adrian Bot
Syh-Jae Lin,Dah-Chin Yan,Yen-Chang Lee et al.
Syh-Jae Lin et al.
Owing to its easier accessibility and less severe graft-versus-host disease, umbilical cord blood (UCB) has been increasingly used as an alternative to bone marrow for hematopoietic stem-cell transplantation. Naiveté of UCB lymphocytes, ho...
M Irshad,I Khushboo,Shiwani Singh et al.
M Irshad et al.
The present manuscript represents an updated review on different aspects of immunology involved during hepatitis C virus infection in human beings. This includes a brief mention of HCV structure, presentation of viral components to host imm...
Regulatory effect of extracellular signal-regulated kinases (ERK) on type I collagen synthesis in human dermal fibroblasts stimulated by IL-4 and IL-13 [0.03%]
ERK对IL-4和IL-13诱导的人真皮成纤维细胞I型胶原合成的调节作用
Rashpal K Bhogal,Constantin A Bona
Rashpal K Bhogal
Synthesis of collagen is up-regulated by pro-fibrogenic growth factors and cytokines such as TGF-beta 1, IL-4, and IL-13 binding to their corresponding cell membrane receptors of fibroblasts. The ERK pathway is an important MAPK signaling p...
Marc P Girard,Geetha P Bansal
Marc P Girard
HIV vaccine research is at a crossroads carefully contemplating on the next path. The unexpected results of the Merck vaccine trial, while providing a stunning blow to a field in dire need of a protective vaccine, has also raised several fu...
Hsiu-Ting Tsai,Tzu-Hsin Tsai,Tsong-Ming Lu et al.
Hsiu-Ting Tsai et al.
The interaction between immune responses and hepatitis B virus (HBV) is coordinated between innate and adaptive immunity. Anti-HBs antibodies protect the host by blocking the binding ability of HBV. Anti-HBc antibodies are detected with per...
Development of a vaccine against pandemic influenza viruses: current status and perspectives [0.03%]
流感大流行疫苗的研发现状及展望
Petr O Ilyinskii,Galini Thoidis,Alexander M Shneider
Petr O Ilyinskii
The constant threat of a new influenza pandemic, which may be caused by a highly pathogenic avian influenza virus, necessitates the development of a vaccine capable of providing efficient, long-term, and cost-effective protection. Proven av...
Adrian Bot
Adrian Bot