Understanding the role of regulatory T cell-derived small extracellular vesicles in suppression of anti-tumor immune response: Key to advancing cancer immunotherapy [0.03%]
理解调节性T细胞源性小胞外囊泡在抑制抗肿瘤免疫反应中的作用：推动癌症免疫治疗的关键
Pranav Seth,Subrata Kumar Pore,Sonja Ludwig et al.
Pranav Seth et al.
Regulatory T cells (Tregs) represent a distinct T cell subpopulation crucial for preserving immune homeostasis. Their primary function is to facilitate self-tolerance and suppress other immune responses, achieved through multifaceted mechan...
Comprehensive review on immunotherapy for hepatocellular carcinoma: Current status and future perspectives [0.03%]
肝细胞癌免疫治疗综合述评：现状与未来展望
Swetha Pulakuntla,Gouthami Kuruvalli,Mrinalini Mohan et al.
Swetha Pulakuntla et al.
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, remains a major global health concern due to its high incidence and mortality rates. Although advances in surgery, chemotherapy, and radiotherapy have improved ma...
Recent advances in dendritic cell-derived exosomes in cancer and cancer stem cell therapy [0.03%]
最近基于树突状细胞系外体的癌症及癌症干细胞治疗研究进展
Radhwan Abdul Kareem,Hayder Naji Sameer,Zainab H Athab et al.
Radhwan Abdul Kareem et al.
Exosomes (EXOs), membrane vesicles, have garnered significant attention in cancer treatments as a novel means by which cells communicate with each other. EXOs are recognized for their pathophysiological participation in cancer therapy and t...
Immunotherapeutic potential of "Breg-Treg" vs "Th9-Th17" cell axis in post-menopausal osteoporosis [0.03%]
绝经后骨质疏松症中"Breg-Treg"与"Th9-Th17"细胞轴的免疫治疗潜力
Asha Bhardwaj,Leena Sapra,Rupesh K Srivastava
Asha Bhardwaj
Osteoporosis is a skeletal disease that affects the microarchitecture and mineralization of the bone, reduces bone strength, and lowers bone mineral density (BMD). Post-menopausal osteoporosis (PMO), caused by estrogen deficiency, is the mo...
Mitochondria in the immune system: Therapeutic potential from mitochondria transfer [0.03%]
线粒体在免疫系统中的作用：基于线粒体转移的治疗潜力
Thao Hoang Nhu Le,Van Thi Tuong Nguyen
Thao Hoang Nhu Le
Mitochondria serve as the powerhouses of living cells, supplying energy and essential building blocks for cellular activities. The immune system exhibits a dynamic and active characteristic within the body, wherein immune cells are constant...
Extracellular vesicles and mononuclear phagocyte axis: Interactions shaping immune responses [0.03%]
细胞外囊泡和单核吞噬细胞轴：塑造免疫反应的相互作用
Tulio J Lopera,Gloria Vásquez,Mauricio Rojas et al.
Tulio J Lopera et al.
Extracellular vesicles (EVs), nano-sized particles enclosed by a lipid membrane, play a pivotal role in cell-to-cell communication as essential mediators in various biological processes and diseases. Despite their ability to interact with m...
Revolutionizing IBD therapy: Insights into contemporary treatment strategies [0.03%]
革命性IBD治疗：当代治疗策略的新见解
Pooja Kushwaha,Rahila Qureshi,Nooruddin Khan et al.
Pooja Kushwaha et al.
Inflammatory bowel disease (IBD) varies in prevalence globally. Recent rise in IBD cases mirrors evolving health landscape due to urbanization and lifestyle changes worldwide. Existing drugs for IBD include aminosalicylates, corticosteroids...
Immune-mediated membranous nephropathy: Innovations in pathogenetic modeling and mechanistic insights [0.03%]
免疫介导的膜性肾病：发病机制建模和机制研究的新进展
Chunjie Zhang,Zaiping Xu,Ye Feng et al.
Chunjie Zhang et al.
Membranous nephropathy (MN), an autoimmune cause of adult nephrotic syndrome, is driven by podocyte-targeting antibodies against PLA2R/THSD7A. Current models fail to fully capture human disease progression. This review evaluates three trans...
Antibody-drug conjugates in breast cancer: From therapeutic and immune activation mechanisms to resistance prevention [0.03%]
抗体偶联药物在乳腺癌中的应用：从治疗和免疫激活机制到抗耐药性
Nik Mohd Asri Nik Amirah Auni,Norhanani Mohd Redzwan,Maya Mazuwin Yahya et al.
Nik Mohd Asri Nik Amirah Auni et al.
Antibody-drug conjugates (ADCs) are produced by integrating the specificity of monoclonal antibodies with cytotoxic payloads. ADCs are vital biologics for breast cancer treatment where they not only exert direct cytotoxicity but also promot...
Association between CTLA4 polymorphisms and susceptibility to granulomatosis with polyangiitis [0.03%]
CTLA4基因多态性与肉芽肿伴多血管炎易感性的关联分析
Amirhosein Mohamadi,Naeim Ehtesham,Huriyeh Hashemi et al.
Amirhosein Mohamadi et al.
Background: Granulomatosis with polyangiitis (GPA) is an autoimmune condition. This study evaluated the relationship between CTLA4 gene polymorphisms, specifically rs231775, rs5742909, and rs3087243, and the risk of devel...