The role of tumor-infiltrating B cells in the development and pathogenesis of head and neck cancers: Implications for therapeutic approach [0.03%]
Anita Rezaei,Ava Aghakhani,Farbod Bahreini et al.
Anita Rezaei et al.
Head and neck cancers (HNCs) pose a significant global health challenge, with treatment complexities and profound impacts on patient quality of life. Tumor-infiltrating B cells (TIBs) within the tumor microenvironment (TME) are emerging as ...
WC1-mediated co-stimulation in γδ T cells: Insights from ruminants and perspectives for human immunotherapy [0.03%]
反刍动物WC1介导的γδT细胞共刺激的启示及其在人类免疫治疗中的应用前景
Rümeysa Berra Karataş,Furkan Ayaz,Esra Aydemir
Rümeysa Berra Karataş
Gamma-delta (γδ) T cells, which bridge innate and adaptive immunity, are attractive candidates for immunotherapy. Significant interspecies differences exist, particularly between humans and ruminants. In ruminants, γδ T cells are a majo...
Association between circulating inflammatory cytokine levels and the risk of polymyositis: A bidirectional Mendelian randomization study [0.03%]
循环炎症细胞因子水平与多发性肌炎风险之间的关联：双向孟德尔随机化研究
Jiang Shao,Jinjiao Xie,Xiaoli Zheng et al.
Jiang Shao et al.
Background: Analyses of the association between circulating inflammatory cytokine levels and polymyositis (PM) remains challenging because of the limitations of traditional observational studies. Therefore, we used Mendel...
CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner [0.03%]
METTL3通过IGF2BP1依赖的方式调节CKS2促进骨肉瘤进展
Zhiyong Feng,Li Zhang
Zhiyong Feng
Background: Emerging evidence implicates N6-methyladenosine (m6A) RNA modification in osteosarcoma (OS) pathogenesis, but the downstream effectors and regulatory networks remain not fully elucidated. Cyclin-dependent kina...
Understanding the role of regulatory T cell-derived small extracellular vesicles in suppression of anti-tumor immune response: Key to advancing cancer immunotherapy [0.03%]
理解调节性T细胞源性小胞外囊泡在抑制抗肿瘤免疫反应中的作用：推动癌症免疫治疗的关键
Pranav Seth,Subrata Kumar Pore,Sonja Ludwig et al.
Pranav Seth et al.
Regulatory T cells (Tregs) represent a distinct T cell subpopulation crucial for preserving immune homeostasis. Their primary function is to facilitate self-tolerance and suppress other immune responses, achieved through multifaceted mechan...
Comprehensive review on immunotherapy for hepatocellular carcinoma: Current status and future perspectives [0.03%]
肝细胞癌免疫治疗综合述评：现状与未来展望
Swetha Pulakuntla,Gouthami Kuruvalli,Mrinalini Mohan et al.
Swetha Pulakuntla et al.
Hepatocellular carcinoma (HCC), the most common form of primary liver cancer, remains a major global health concern due to its high incidence and mortality rates. Although advances in surgery, chemotherapy, and radiotherapy have improved ma...
Recent advances in dendritic cell-derived exosomes in cancer and cancer stem cell therapy [0.03%]
最近基于树突状细胞系外体的癌症及癌症干细胞治疗研究进展
Radhwan Abdul Kareem,Hayder Naji Sameer,Zainab H Athab et al.
Radhwan Abdul Kareem et al.
Exosomes (EXOs), membrane vesicles, have garnered significant attention in cancer treatments as a novel means by which cells communicate with each other. EXOs are recognized for their pathophysiological participation in cancer therapy and t...
Immunotherapeutic potential of "Breg-Treg" vs "Th9-Th17" cell axis in post-menopausal osteoporosis [0.03%]
绝经后骨质疏松症中"Breg-Treg"与"Th9-Th17"细胞轴的免疫治疗潜力
Asha Bhardwaj,Leena Sapra,Rupesh K Srivastava
Asha Bhardwaj
Osteoporosis is a skeletal disease that affects the microarchitecture and mineralization of the bone, reduces bone strength, and lowers bone mineral density (BMD). Post-menopausal osteoporosis (PMO), caused by estrogen deficiency, is the mo...
Mitochondria in the immune system: Therapeutic potential from mitochondria transfer [0.03%]
线粒体在免疫系统中的作用：基于线粒体转移的治疗潜力
Thao Hoang Nhu Le,Van Thi Tuong Nguyen
Thao Hoang Nhu Le
Mitochondria serve as the powerhouses of living cells, supplying energy and essential building blocks for cellular activities. The immune system exhibits a dynamic and active characteristic within the body, wherein immune cells are constant...
Extracellular vesicles and mononuclear phagocyte axis: Interactions shaping immune responses [0.03%]
细胞外囊泡和单核吞噬细胞轴：塑造免疫反应的相互作用
Tulio J Lopera,Gloria Vásquez,Mauricio Rojas et al.
Tulio J Lopera et al.
Extracellular vesicles (EVs), nano-sized particles enclosed by a lipid membrane, play a pivotal role in cell-to-cell communication as essential mediators in various biological processes and diseases. Despite their ability to interact with m...