Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection [0.03%]
巨噬细胞标志物和基因特征谱系分析揭示了间充质干细胞介导的ANKA感染小鼠免疫调节作用
Aarti Gupta,Reva Sharan Thakur,Rajesh Kumar Ojha et al.
Aarti Gupta et al.
Background: Cerebral malaria (CM) is a life-threatening neurological complication of Plasmodium falciparum infection characterized by excessive inflammation, blood-brain barrier (BBB) disruption, and immune dysregulation....
Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota [0.03%]
天然抗原景观塑造肠调节性T细胞：自身抗原、饮食和微生物群
Jaeu Yi
Jaeu Yi
The gut represents a melting pot of distinct classes of antigens derived from self antigens, dietary components, and the commensal microbiota. To maintain tolerance to innocuous antigens while preserving the capacity to respond to potential...
Upregulation of ADAM10 reinforces CD8+ T cells toward exhaustion in the TME [0.03%]
ADAM10上调使CD8⁺ T细胞在肿瘤微环境中趋向耗竭
Ahmed M E Abdalla,Yu Miao,Yasir A Taha et al.
Ahmed M E Abdalla et al.
Using cytotoxic CD8+ T cell-mediated cellular immunity has shown considerable efficacy in cancer treatment. However, the effectiveness of these cells against solid tumors is limited by the presence of an immunosuppressive tumor microenviron...
PTX3 promotes macrophage efferocytosis and inflammation resolution in granulomatous mastitis [0.03%]
PTX3促进肉芽肿性乳腺炎中巨噬细胞的促凋亡作用和炎症消退反应
Danqing Song,Jiayan Ni,Lijuan Sun et al.
Danqing Song et al.
Granulomatous mastitis (GM) is an inflammatory breast disease. Pentraxin 3 (PTX3) is frequently dysregulated in inflammatory diseases. C. parakroppenstedtii. infection was applied to establish a rat GM model. Histological analysis showed th...
Exosome-based strategies to enhance CAR-T cell therapy for systemic lupus erythematosus: A promising new frontier [0.03%]
基于外泌体增强CAR-T细胞治疗系统性红斑狼疮策略：一个有前景的新前沿
Binbin Li,Ruifan Wen,Kimsor Hong et al.
Binbin Li et al.
Dysregulated B lymphocyte activation plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE), making it a promising target for therapeutic intervention. Chimeric antigen receptor T cell (CAR-T) therapy, specifically t...
Immunoregulation by DC and T cells in psoriasis with probable immunotherapeutic approaches [0.03%]
银屑病中DC和T细胞的免疫调节及可能的免疫治疗方法
Sharmistha Kundu,Rajat Paul,Kaustav Chakraborty
Sharmistha Kundu
Psoriasis is a chronic, immune-mediated inflammatory disorder with systemic implications beyond its cutaneous manifestations. Its pathogenesis involves a complex interplay between genetic predisposition, environmental triggers, and immune d...
The role of tumor-infiltrating B cells in the development and pathogenesis of head and neck cancers: Implications for therapeutic approach [0.03%]
肿瘤浸润B细胞在头颈癌发生发展及病理机制中的作用及治疗意义
Anita Rezaei,Ava Aghakhani,Farbod Bahreini et al.
Anita Rezaei et al.
Head and neck cancers (HNCs) pose a significant global health challenge, with treatment complexities and profound impacts on patient quality of life. Tumor-infiltrating B cells (TIBs) within the tumor microenvironment (TME) are emerging as ...
WC1-mediated co-stimulation in γδ T cells: Insights from ruminants and perspectives for human immunotherapy [0.03%]
反刍动物WC1介导的γδT细胞共刺激的启示及其在人类免疫治疗中的应用前景
Rümeysa Berra Karataş,Furkan Ayaz,Esra Aydemir
Rümeysa Berra Karataş
Gamma-delta (γδ) T cells, which bridge innate and adaptive immunity, are attractive candidates for immunotherapy. Significant interspecies differences exist, particularly between humans and ruminants. In ruminants, γδ T cells are a majo...
Association between circulating inflammatory cytokine levels and the risk of polymyositis: A bidirectional Mendelian randomization study [0.03%]
循环炎症细胞因子水平与多发性肌炎风险之间的关联：双向孟德尔随机化研究
Jiang Shao,Jinjiao Xie,Xiaoli Zheng et al.
Jiang Shao et al.
Background: Analyses of the association between circulating inflammatory cytokine levels and polymyositis (PM) remains challenging because of the limitations of traditional observational studies. Therefore, we used Mendel...
CKS2, regulated by METTL3, contributes to osteosarcoma progression in an IGF2BP1-dependent manner [0.03%]
METTL3通过IGF2BP1依赖的方式调节CKS2促进骨肉瘤进展
Zhiyong Feng,Li Zhang
Zhiyong Feng
Background: Emerging evidence implicates N6-methyladenosine (m6A) RNA modification in osteosarcoma (OS) pathogenesis, but the downstream effectors and regulatory networks remain not fully elucidated. Cyclin-dependent kina...