Regulatory T cells in the tumor microenvironment: Mechanisms and clinical implications [0.03%]
肿瘤微环境中的调节性T细胞：机制及临床意义
Haewon Song,Jihyun Kim,Sung-Min Hwang
Haewon Song
Regulatory T cells (Tregs) are essential mediators of immune tolerance that maintain tissue homeostasis by restraining excessive immune activation. In cancer, these regulatory mechanisms are reinforced within malignant tissues and contribut...
Leptin in metabolic-immune crosstalk: Mechanisms of T cell regulation and implications for autoimmune disease therapy [0.03%]
代谢-免疫交叉 talk 中的瘦素：T 细胞调控机制及其自身免疫性疾病治疗意义
Yuezheng Xiao,Haijing Wu,Fanghan Ji et al.
Yuezheng Xiao et al.
Leptin, a multifunctional hormone primarily secreted by adipose tissue, plays a crucial role in regulating body weight, appetite, energy expenditure, and metabolic processes. Beyond regulating metabolic pathways, leptin demonstrates notable...
Metabolic alterations in the tumor microenvironment influence the anti-tumor immune function of CD8+ T cells via epigenetic modifications [0.03%]
肿瘤微环境中的代谢改变通过表观遗传修饰影响CD8⁺T细胞的抗肿瘤免疫功能
Yaru Liu,Wei Du,Weimin Deng
Yaru Liu
Metabolic reprogramming within the tumor microenvironment (TME) is a pivotal driver of CD8+ T cell dysfunction in cancer. Tumor cells outcompete T cells for essential nutrients, including glucose and amino acids, while accumulating immunosu...
Macrophage markers and gene signature profiling reveals mesenchymal stem cells mediated immune modulation in Plasmodium berghei ANKA infection [0.03%]
巨噬细胞标志物和基因特征谱系分析揭示了间充质干细胞介导的ANKA感染小鼠免疫调节作用
Aarti Gupta,Reva Sharan Thakur,Rajesh Kumar Ojha et al.
Aarti Gupta et al.
Background: Cerebral malaria (CM) is a life-threatening neurological complication of Plasmodium falciparum infection characterized by excessive inflammation, blood-brain barrier (BBB) disruption, and immune dysregulation....
Natural antigen landscape shaping intestinal Treg cells: Self, diet, and microbiota [0.03%]
天然抗原景观塑造肠调节性T细胞：自身抗原、饮食和微生物群
Jaeu Yi
Jaeu Yi
The gut represents a melting pot of distinct classes of antigens derived from self antigens, dietary components, and the commensal microbiota. To maintain tolerance to innocuous antigens while preserving the capacity to respond to potential...
Upregulation of ADAM10 reinforces CD8+ T cells toward exhaustion in the TME [0.03%]
ADAM10上调使CD8⁺ T细胞在肿瘤微环境中趋向耗竭
Ahmed M E Abdalla,Yu Miao,Yasir A Taha et al.
Ahmed M E Abdalla et al.
Using cytotoxic CD8+ T cell-mediated cellular immunity has shown considerable efficacy in cancer treatment. However, the effectiveness of these cells against solid tumors is limited by the presence of an immunosuppressive tumor microenviron...
PTX3 promotes macrophage efferocytosis and inflammation resolution in granulomatous mastitis [0.03%]
PTX3促进肉芽肿性乳腺炎中巨噬细胞的促凋亡作用和炎症消退反应
Danqing Song,Jiayan Ni,Lijuan Sun et al.
Danqing Song et al.
Granulomatous mastitis (GM) is an inflammatory breast disease. Pentraxin 3 (PTX3) is frequently dysregulated in inflammatory diseases. C. parakroppenstedtii. infection was applied to establish a rat GM model. Histological analysis showed th...
Exosome-based strategies to enhance CAR-T cell therapy for systemic lupus erythematosus: A promising new frontier [0.03%]
基于外泌体增强CAR-T细胞治疗系统性红斑狼疮策略：一个有前景的新前沿
Binbin Li,Ruifan Wen,Kimsor Hong et al.
Binbin Li et al.
Dysregulated B lymphocyte activation plays a pivotal role in the pathogenesis of systemic lupus erythematosus (SLE), making it a promising target for therapeutic intervention. Chimeric antigen receptor T cell (CAR-T) therapy, specifically t...
Immunoregulation by DC and T cells in psoriasis with probable immunotherapeutic approaches [0.03%]
银屑病中DC和T细胞的免疫调节及可能的免疫治疗方法
Sharmistha Kundu,Rajat Paul,Kaustav Chakraborty
Sharmistha Kundu
Psoriasis is a chronic, immune-mediated inflammatory disorder with systemic implications beyond its cutaneous manifestations. Its pathogenesis involves a complex interplay between genetic predisposition, environmental triggers, and immune d...
The role of tumor-infiltrating B cells in the development and pathogenesis of head and neck cancers: Implications for therapeutic approach [0.03%]
肿瘤浸润B细胞在头颈癌发生发展及病理机制中的作用及治疗意义
Anita Rezaei,Ava Aghakhani,Farbod Bahreini et al.
Anita Rezaei et al.
Head and neck cancers (HNCs) pose a significant global health challenge, with treatment complexities and profound impacts on patient quality of life. Tumor-infiltrating B cells (TIBs) within the tumor microenvironment (TME) are emerging as ...