Yolanda Sanz,Giada De Pama,Moisés Laparra
Yolanda Sanz
Celiac disease is a multifactorial disorder that involves interactions between genetic and environmental factors. Gluten proteins are responsible for the symptoms of celiac disease, but other environmental factors that influence the intesti...
E V Marietta,C S David,J A Murray
E V Marietta
Several animal models have been recently developed to recapitulate various components of the complex process that is celiac disease. In addition to the increasing diversity of murine models there are now monkey models of celiac disease. Mou...
Katri Lindfors,Outi Koskinen,Katri Kaukinen
Katri Lindfors
In celiac disease, highly sensitive and specific serum endomysial and transglutaminase 2 antibody tests are widely used in identifying patients for diagnostic endoscopy and small-bowel biopsy. In addition, the recently developed deamidated ...
Celiac disease: progress towards diagnosis and definition of pathogenic mechanisms [0.03%]
乳糜泻：诊断和致病机制研究进展
Mauro Rossi,Adrian Bot
Mauro Rossi
The current issue of the International Reviews of Immunology is dedicated entirely to Celiac Disease (CD). Recent development of additional biomarkers and diagnostics resulted in a sharp revision of the prevalence of this condition, with a ...
Cheryl Lai-Lai Chiang,Lana E Kandalaft,George Coukos
Cheryl Lai-Lai Chiang
Whole tumor cell lysates can serve as excellent multivalent vaccines for priming tumor-specific CD8(+) and CD4(+) T cells. Whole cell vaccines can be prepared with hypochlorous acid oxidation, UVB-irradiation and repeat cycles of freeze and...
Sperm protein 17: clinical relevance of a cancer/testis antigen, from contraception to cancer immunotherapy, and beyond [0.03%]
精子蛋白17：癌症/睾丸抗原的临床意义，从避孕到肿瘤免疫治疗及展望
Maurizio Chiriva-Internati
Maurizio Chiriva-Internati
Sperm protein 17 belongs to the cancer/testis antigen family and was found to play a key role in the cell fusion process between the mammalian spermatozoa and egg. Sperm protein 17-specific autoantibodies in vasectomized males suggest its h...
Cancer testis antigens: novel biomarkers and targetable proteins for ovarian cancer [0.03%]
癌症睾丸抗原：卵巢癌的新型生物标志物和可作用蛋白
Leonardo Mirandola,Martin J Cannon,Everardo Cobos et al.
Leonardo Mirandola et al.
Ovarian cancer is the fifth leading cause of cancer death in women and the leading cause from gynecological malignancies. Despite the recently improved outcomes of new chemotherapeutical agents in the therapy of ovarian cancer and the incre...
Cailin Moira Wilke,Ilona Kryczek,Weiping Zou
Cailin Moira Wilke
The major human antigen-presenting cells (APCs) include monocytes/macrophages, myeloid dendritic cells (mDC), plasmacytoid dendritic cells (pDC), and B cells. These APC subsets have been observed in ovarian tumor environments. Their phenoty...
Suzanne R Thibodeaux,Tyler J Curiel
Suzanne R Thibodeaux
This review covers immune and anatomic considerations specific for ovarian cancer immune therapy. Prior approaches and potential reasons for lack of better efficacy are discussed, along with newer approaches in pre-clinical and early clinic...
Peritoneal immune system in patients with advance epithelial ovarian cancer [0.03%]
晚期上皮性卵巢癌患者腹膜免疫系统的研究
Iwona Wertel,Aldona Nowicka,Ewelina Rogala et al.
Iwona Wertel et al.
The development of epithelial ovarian cancer is associated with changes in the peritoneal cavity microenvironment. Tumor cells produce different factors, which impairs differentiation, maturation, and function of antigen-presenting cells. I...