Stanniocalcin-1 confers neuroprotection against ischemic injury via calreticulin-dependent activation of the CAMKK2/AMPK/GSK-3β/Nrf2 pathway [0.03%]
脑缺血损伤下调控色素上皮细胞运输蛋白依赖的CAMKK2/AMPK/GSK-3β/Nrf2信号通路发挥神经保护作用机制研究：斯坦尼钙素1的新功能及其分子机制
Yunhao Xu,Chang Liu,Jiachen Li et al.
Yunhao Xu et al.
This study explores the neuroprotective effects of Stanniocalcin-1 (STC1) in the context of ischemic stroke, a major cause of death and disability worldwide. Although STC1 is recognized for its cytoprotective properties, its role in cerebra...
Quantitative susceptibility mapping for iron quantification of deep gray matter in patients with ischemic cerebrovascular events: A systematic review [0.03%]
定量磁化率图测量缺血性脑血管事件患者深灰质铁含量的系统评价
Yaqi Chen,Huan Wang,Keying Wu et al.
Yaqi Chen et al.
Quantitative susceptibility mapping (QSM) enables non-invasive assessment of brain iron dysregulation following ischemic injury. We conducted a systematic review to evaluate the role of QSM-derived susceptibility in deep gray matter (DGM) n...
Mapping cardiac and respiratory pulsations simultaneously with functional connectivity in the rat brain using zero echo time fMRI [0.03%]
利用零回波时间功能磁共振成像同步绘制大鼠心脏和呼吸脉搏及脑功能连接地图
Ekaterina Paasonen,Petteri Stenroos,Antonio Caulin Atienzar et al.
Ekaterina Paasonen et al.
Vascular pulsations are increasingly recognized as key contributors to cerebral perfusion and brain clearance mechanisms, with alterations linked to aging and neurodegenerative diseases. However, capturing fast physiological dynamics in pre...
In vivo microvascular flow quantification in the mouse brain using row-column ultrasound localization microscopy and directed graph analysis [0.03%]
基于行列式超声定位显微镜和有向图分析的小鼠脑在体微血管血流量化
Adrien Bertolo,Jeremy Ferrier,Oscar Demeulenaere et al.
Adrien Bertolo et al.
Brain perfusion relies on a complex vascular network of arteries, veins, and capillaries to meet its constant demand for oxygen and nutrients. Disruption of this microvascular system is a hallmark of many neurological disorders, including s...
Ester Licastro,Rohan Mahesh Patil,Yasin Eshraghi et al.
Ester Licastro et al.
In the last three decades, a huge amount of data and number of reports have proved that ischemic brain damage develops differently based on the time of the day at which it occurs. Differences in circadian rhythms between nocturnal rodent mo...
Endothelial energy failure as a therapeutic target in elderly strokes [0.03%]
内皮细胞能量衰竭在老年卒中的治疗作用及靶点研究
Sanaz Nasoohi,Farehe Ebrahimi,Candice M Brown et al.
Sanaz Nasoohi et al.
Despite the fact that a third of stroke patients are over the age of 80, specialized stroke management in the elderly is in its infancy. The signature poor blood flow in the aged brain has been shown to synchronize with impaired neurovascul...
[11C]PS13 PET shows that age is positively correlated with constitutively expressed cyclooxygenase-1 in the brain [0.03%]
[11C]PS13正电子发射断层显像(PET)显示脑内年龄与环氧化酶-1的固有表达呈正相关
Paul Parcon,Mia Scrabis,Martin Nørgaard et al.
Paul Parcon et al.
Cyclooxygenase-1 (COX-1), an essential enzyme in the synthesis of pro-inflammatory prostanoids from arachidonic acid, is widely expressed in the brain, primarily in microglia. Previous studies from our laboratory found that the novel positr...
Targeting senescence mitigates the deleterious effects of midlife obesity on neurovascular function by partially restoring blood-brain barrier integrity and neurovascular coupling [0.03%]
靶向衰老通过部分恢复血脑屏障的完整性和神经血管调节来缓解中年肥胖对神经血管功能的不利影响
Sharon Negri,Madison Milan,Rakesh Rudraboina et al.
Sharon Negri et al.
Midlife obesity is a major risk factor for vascular cognitive impairment (VCI) and dementia, but the cellular mechanisms linking obesity to brain microvascular dysfunction remain unclear. Here, we show that high-fat diet (HFD)-induced obesi...
Natalia Ancona,Ashish K Rehni,Suresh Mallepalli et al.
Natalia Ancona et al.
Hypoglycemia is a frequent and often serious complication of diabetes management. While its acute effects on cognition are well documented, growing evidence suggests that recurrent or severe hypoglycemia exposure may also contribute to long...
Cerebrovascular recovery drives restoration of neurometabolite levels after mild COVID-19 [0.03%]
轻型新冠肺炎后的脑代谢物恢复由脑血管复苏驱动
Devin B Coe,Francesca Branzoli,Nicholas Shaff et al.
Devin B Coe et al.
SARS-CoV-2 infection can trigger broad acute-stage endothelial dysfunction that is often followed by neurocognitive post-acute sequelae (PASC) chronically. It is thus of interest to evaluate long-term post-infection cerebrovascular function...