EXPRESS: Oscillating Hypercapnia Induces Neural Abundant Protein Efflux and Potential Depletion in Health and Chronic Traumatic Brain Injury [0.03%]
急性高低碳酸血症对正常和慢性脑损伤后神经元的影响
Andrew Mayer,Tracey V Wick,Upasana Nathaniel et al.
Andrew Mayer et al.
Emerging preclinical and clinical evidence suggests that low frequency hemodynamic oscillations drive CSF flow, which in turn mediates glymphatic clearance. The current study investigated whether CO2-induced low frequency hemodynamic oscill...
EXPRESS: Quantitative functional BOLD (qfBOLD): A Combined Gradient-Echo and Spin-Echo Framework for Oxygen Extraction Fraction (OEF) Mapping with functional MRI [0.03%]
基于功能磁共振成像的氧提取分数(OEF)图谱的定量功能性BOLD(qfBOLD)联合梯度回波和自旋回波框架
Antonio M Chiarelli,Lucie Chalet,Sara Pomante et al.
Antonio M Chiarelli et al.
We present a novel framework for OEF mapping with MRI, based on temporal variations in Gradient Echo (GE) and Spin-Echo (SE) BOLD signals induced by isometabolic modulations in CBF. This approach, termed quantitative functional BOLD (qfBOLD...
Metabolic profiling and biomarker identification in idiopathic intracranial hypertension with venous sinus stenosis [0.03%]
特发性颅内高压合并静脉窦狭窄的代谢谱及生物标志物识别研究
Nan Wang,Baoshan Qiu,Ketao Tu et al.
Nan Wang et al.
Idiopathic intracranial hypertension (IIH) with venous sinus stenosis (VSS) may lead to a vicious cycle of elevated intracranial pressure (ICP) and subsequent brain damage. This study aimed to characterize metabolic alterations and identify...
EXPRESS: Heightened respiratory brain pulsations indicate fluid dynamic dysfunction in early multiple sclerosis [0.03%]
MS脑脉动力功能障碍的影像学生物标志物：脑脊液动力学异常与呼吸系统疾病的关系研究
Jere Haverinen,Mervi Ryytty,Harri Rusanen et al.
Jere Haverinen et al.
Multiple sclerosis (MS) is characterised by perivascular space inflammation and perivenous neuronal demyelination. Cerebrospinal fluid (CSF) is driven along these perivascular structures by vasomotor waves, respiratory and cardiovascular pu...
Stroke-induced gut microbiome dysbiosis accelerates Alzheimer's disease progression [0.03%]
卒中引起的肠道菌群失调加速阿尔茨海默病进展
Chetan Aware,Carter Woods,Pavlo Khodakivskyi et al.
Chetan Aware et al.
Stroke survivors face an elevated risk of developing Alzheimer's disease (AD), yet the biological mechanisms linking these conditions remain poorly defined. Here, we show that a stroke-induced gut microbiome is a key driver of AD-related pa...
Mechanisms of neurovascular regulation in health and disease: Insights from experimental animal models [0.03%]
健康与疾病状态下的脑血管调节机制——实验动物模型提供新视角
Nicole Casey,Giuseppe Faraco
Nicole Casey
The brain is an energetically demanding organ that relies on a continuous and precisely regulated blood supply to sustain neuronal function. This regulation is achieved through an intricate vascular network and sophisticated control mechani...
Occurrence of cerebral infarction, a threshold-sensitive nonlinear process: Lessons from a new stroke model, NAIM [0.03%]
脑梗死发生的阈值敏感非线性过程——从新的卒中模型（加权指数模型）得到的启示
Jinyong Chung,Dong-Seok Gwak,Beom Joon Kim et al.
Jinyong Chung et al.
The lifetime accumulation of vascular risk factors shapes susceptibility to ischemic stroke but does not account for the striking divergence in tissue outcome following large artery occlusion, as some individuals experience infarction of va...
Focused ultrasound opens the blood-brain barrier and reveals an age-dependent dissociation between resting cerebral blood flow and neurovascular coupling [0.03%]
聚焦超声打开血脑屏障并揭示了静息脑血流与神经血管耦合之间的年龄依赖性解离
Sharon Negri,Madison Milan,Rakesh Rudraboina et al.
Sharon Negri et al.
Focused ultrasound (FUS) in combination with nanobubbles enables transient, localized opening of the blood-brain barrier (BBB), facilitating targeted therapeutic delivery. However, the cerebrovascular consequences of BBB opening across the ...
Leukocyte-endothelial interactions and brain capillary function in neurological diseases [0.03%]
神经性疾病中的白细胞-血管内皮细胞相互作用和脑毛细血管功能
Hyun-Kyoung Lim,Andy Y Shih,Juliane Gust
Hyun-Kyoung Lim
Enhanced leukocyte-endothelial interactions are a hallmark pathological feature in brain disease. Preclinical studies have demonstrated increased leukocyte adhesion at the capillary level as a major contributor to cerebral blood flow (CBF) ...
The role of sex as a biological variable in neurocritical care: Fundamentals of cerebrovascular physiology with clinical implications [0.03%]
性别作为神经重症护理中生物学变量的作用：具有临床意义的脑血管生理学基础知识
Lauren E Maier,Jatinder S Minhas,Cornelia Hoedemaekers et al.
Lauren E Maier et al.
Ischemic stroke, intracerebral hemorrhage (ICH), aneurysmal subarachnoid hemorrhage (aSAH), global hypoxic ischemic brain injury following cardiac arrest (HIBI), and traumatic brain injury (TBI) present clinical pathologies that share brain...