EXPRESS: Global Increases in Brain Glucose Metabolism Following Acute N,N-Dimethyltryptamine and Harmine Administration in Healthy Volunteers: A randomised [18F]FDG-PET Study [0.03%]
健康志愿者在接受N-甲基二乙酸盐和 harmine 之后大脑葡萄糖代谢的全球增长：一项随机[18F]fdg-pet研究
Klemens Egger,Robert Bozsak,Helena Dorothea Dorothea Aicher et al.
Klemens Egger et al.
Background: Classical psychedelics such as N,N-dimethyltryptamine (DMT) modulate consciousness via serotonergic receptor agonism, and are increasingly investigated for their psychotherapeutic potential. When combined with...
EXPRESS: Encephaloduroarteriosynangiosis Effectively Reduces Rebleeding Risk in Adults with Hemorrhagic Moyamoya Disease: A Long-Term Ambidirectional Cohort Study [0.03%]
EXPRESS：半侧颅骨膜动脉血管网形成术可有效降低出血性 moyamoya 病患者的再出血风险：一项长期双向队列研究
Qian-Nan Wang,Xiao-Peng Wang,Xiao-Mei Li et al.
Qian-Nan Wang et al.
Objective: This cohort study was conducted using prospective and retrospective data to investigate whether indirect encephaloduroarteriosynangiosis (EDAS) revascularization can reduce the risk of rebleeding in adult patie...
EXPRESS: Quantification of 18F-SynVesT-1 binding in healthy aging and head-to-head comparison with 11C-UCB-J [0.03%]
氟[18F]SynVesT-1在健康老年人脑中的结合及与碳[11C]UCB-J的比较研究
Greet Vanderlinden,Charles Carron,Jolien Van Opstal et al.
Greet Vanderlinden et al.
Synaptic vesicle glycoprotein 2A (SV2A) PET imaging enables the estimation of synaptic density in the brain. The most widely used SV2A tracer, 11C-UCB-J, shows age-related effects in healthy volunteers (HV) and its short radioactive half-li...
EXPRESS: Meningeal CSF transport varies across parasagittal dura subregions with age in humans [0.03%]
人脑硬膜外侧分区的脑脊液转运随年龄变化而变化
Vadim Malis,Hye Na Jung,Yoshiki Kuwatsuru et al.
Vadim Malis et al.
Background: Cerebrospinal fluid (CSF) transport along meningeal pathways contributes to brain fluid homeostasis and is thought to change with aging, yet quantitative, region-resolved measurements across lifespan remain li...
EXPRESS: Minute- and second-scale hippocampal network dysfunctions in the 3xTgAD mouse model of Alzheimer's disease are prevented by TSPO knockout [0.03%]
APOE基因不同的背景下tau病理引起的小鼠空间工作记忆的性别二态性
Benjamin Vidal,Aurélien M Badina,Violina Dorogan et al.
Benjamin Vidal et al.
The 18kDa translocator protein (TSPO) is widely recognized as a biomarker of neuroinflammation, but recent evidence suggests that it may also play a direct role in the pathophysiology of neurological conditions with an inflammatory componen...
EXPRESS: Commentary to "The role of dopamine decline, astrocyte reactivity, and cerebral small-vessel disease in cognitive aging" [0.03%]
述评：多巴胺减少、星形胶质细胞反应性和脑小血管病在认知衰老中的作用
Karl Herholz
Karl Herholz
Molecular imaging of the interaction between astrocytes and neurons in humans is an important yet challenging task. While previous studies indicated that activation of astrocytes may contribute to the loss of neurons, the paper by Crine et ...
EXPRESS: Single-tracer [18F]FDG PET quantification of blood-brain barrier permeability and cerebral blood flow: Validation using dual-tracer PET [0.03%]
express：单示踪剂[18f]fdg pet量化血脑屏障通透性和脑血流：双示踪剂pet验证
Kevin J Chung,Terry Jones,Yasser G Abdelhafez et al.
Kevin J Chung et al.
Imaging the blood-brain barrier (BBB) permeability of molecular PET tracers may allow pathway-specific assessment of the diverse transport mechanisms expressed at the BBB. However, PET quantification of BBB permeability typically requires d...
EXPRESS: Remote ischemic peconditioning and postconditioning reduced cerebral ischemic injury modulating inflammatory responses and metabolic pathways [0.03%]
远程缺血预适应和后适应通过调节炎症反应和代谢通路减少脑缺血损伤
Coral Torres-Querol,Reinald Pamplona,Gloria Arqué et al.
Coral Torres-Querol et al.
Remote ischemic conditioning (RIC) mitigates ischemic injury through transient, repetitive vascular occlusion in a limb distant from the injury site. Although its protective effects are recognized, the underlying mechanisms remain incomplet...
EXPRESS: Metabolic reprogramming of oligodendrocyte lineage cells in ischemic stroke: insights from literature review and single-cell transcriptomic re-analyses [0.03%]
基于文献回顾和单细胞转录组重新分析的脑卒中少突胶质细胞谱系细胞代谢重编程研究
Huijia Zhuang,Xisha Tang,Yu Zhang et al.
Huijia Zhuang et al.
Ischemic stroke (IS) causes white matter (WM) injury and disrupts myelin integrity, contributing to long-term cognitive dysfunction. Oligodendrocyte lineage cells, particularly oligodendrocyte precursor cells (OPCs), are essential for post-...
EXPRESS: Interventions and Outcome Measures for Motor Recovery After Ischemic Stroke: The Importance of Intervention-Outcome Alignment [0.03%]
缺血性卒中后促进运动功能恢复的干预措施及疗效评价指标的选择：强调干预措施与结局指标的一致性
Masato Kanazawa,Keigo Tamakoshi,Masahiro Hatakeyama
Masato Kanazawa
Research on stroke recovery has shifted from acute survival to the restoration of function and quality of life. Although many rehabilitative and restorative interventions have shown promising benefits, trial outcomes remain inconsistent. A ...