Network oscillatory dynamics accompany cerebral bioenergetic defence in hypoxia [0.03%]
网络振荡动力学伴随缺氧条件下的脑生物能量防御反应
Damian M Bailey,Benjamin S Stacey,Yaopeng Ma et al.
Damian M Bailey et al.
A network physiology framework investigated how coordinated interactions among multiple organ systems collectively support the preservation of cerebral bioenergetic function and better distinguish adaptive from maladaptive responses to hypo...
EXPRESS: Endothelial glycocalyx degradation, systemic inflammation, and central nervous system injury: a comparative cohort study in adults with and without obesity [0.03%]
内皮糖萼降解、全身性炎症和中枢神经系统损伤：一项成人组队研究，包括有或没有肥胖患者的资料
Yuwei Guo,Xiaojian Fu,Ruiqing Xu et al.
Yuwei Guo et al.
Obesity is associated with chronic systemic inflammation, vascular endothelial dysfunction, and increased risk of central nervous system (CNS) injury, yet the mechanisms linking peripheral inflammation to brain damage remain incompletely un...
EXPRESS: Neuroprotection with delayed maturation of oligodendrocytes after therapeutic hypothermia for mild cerebral ischemia in near-term fetal sheep [0.03%]
表达：治疗性低温后近足月胎羊轻度脑缺血后的神经保护与少突胶质细胞延迟成熟
Alice McDouall,Guido Wassink,Kelly Qishan Q Zhou et al.
Alice McDouall et al.
Many infants with mild hypoxic-ischemic encephalopathy (HIE) are treated with therapeutic hypothermia despite the lack of robust preclinical and clinical data that hypothermia is safe and effective. The aim of this study was to determine if...
Jody L Manners,Jaime Podell,Nicolas Dorsey et al.
Jody L Manners et al.
Traumatic brain injury (TBI) encompasses heterogeneous insults and presentations resulting from blunt or penetrating mechanisms that disrupt normal cerebral function. While the primary injury may demand emergent intervention, secondary inju...
Jiahao Ou,Ketian Hou,Yihan Fu et al.
Jiahao Ou et al.
The blood-brain barrier (BBB) has long been regarded as a passive, protective filter for the brain. This review re-evaluates the role of brain microvascular endothelial cells (BMECs)-from viewing them as static structural components to reco...
EXPRESS: NADPH protects the post-stroke brain by activating the m6A demethylase FTO [0.03%]
NADPH通过激活m6A去甲基化酶FTO保护缺血后的脑部
Anil K Chokkalla,Suresh L Mehta,Mohd Salman et al.
Anil K Chokkalla et al.
N6-methyladenosine (m6A) is the most pronounced epitranscriptomic modification of RNAs. Fat mass and obesity-associated (FTO) demethylates m6A-modified RNAs. Stroke reduces cerebral FTO expression, leading to increased abundance of m6A hype...
EXPRESS: RAGE in neutrophils triggers cerebral vasospasm in the hyperacute phase after subarachnoid hemorrhage [0.03%]
中性粒细胞中的RAGE信号在蛛网膜下腔出血后的超急期内触发脑血管痉挛
Hiroshi Ishii,Munehiro Demura,Tsuyoshi Hattori et al.
Hiroshi Ishii et al.
Subarachnoid hemorrhage (SAH) due to the rupture of an intracranial aneurysm is a highly fatal type of stroke. Cerebral vasospasm (CVS) is a major post-SAH complication leading to delayed ischemic neurological deficits, thereby worsening pa...
EXPRESS: A perivascular perspective on the immune impacts in cerebral amyloid angiopathy [0.03%]
血管周围视角下的脑淀粉样变性血管病免疫效应研究
Beth Eyre,Stephanie K Bonney
Beth Eyre
Cerebral amyloid angiopathy (CAA) is one of the most common small vessel diseases. With the deposition of amyloid beta within the walls of cerebral blood vessels, CAA can result in damage to blood vessels over time and ultimately intracereb...
EXPRESS: 18F]FDG functional PET revisited: a new perspective on the temporal dynamics of brain glucose metabolism [0.03%]
简报：18F]FDG功能正电子发射断层扫描重探：大脑葡萄糖代谢时间动态的新视角
Andreas Hahn,Pia Falb,Matej Murgas et al.
Andreas Hahn et al.
[18F]FDG functional PET (fPET) enables investigation of dynamics in glucose metabolism occurring within seconds. However, the physiological mechanisms supporting rapid metabolic changes necessitate further attention to allow accurate interp...