EXPRESS: Spatiotemporal Dynamics of Direct Cortical Response Depression during Spreading Depolarizations [0.03%]
皮层扩散性 depolarization 期间直接皮层反应抑制的时空动态规律
Daria Vinokurova,Bulat Mingazov,Gulshat Zakirova et al.
Daria Vinokurova et al.
Spreading Depolarizations (SDs) induce a transient depression of cortical activity, including a depression of Direct Cortical Responses (DCRs). Here, we examined the spatiotemporal dynamics of DCR depression during SDs induced by high-potas...
EXPRESS: Plasma metabolic signature of cardiovascular-kidney-metabolic syndrome and incident stroke: a nationwide prospective cohort study [0.03%]
基于全国前瞻性队列研究的心血管-肾脏-代谢综合征的血浆代谢标志物及其卒中发病风险的关联研究
Kaixin Lei,Bojun Ma,Chenxi Lu et al.
Kaixin Lei et al.
Background: Cardiovascular-kidney-metabolic (CKM) syndrome has increasingly affected the middle-aged and elderly population. The relationship between CKM risk factors and stroke at metabolomic level and underlying genetic...
EXPRESS: Stroke-induced immunosuppression is associated with brain injury and poor outcomes in patients receiving intravenous thrombolysis: a multicenter prospective cohort study [0.03%]
急性缺血性脑卒中静脉溶栓患者免疫抑制与脑梗死及预后的关系：一项多中心前瞻性队列研究
Zhong-Yu Cao,Yang Qu,Ze-Yu Hao et al.
Zhong-Yu Cao et al.
Following a stroke, a local inflammatory cascade is triggered, resulting in the systemic diminishment of immune function, known as stroke-induced immunosuppression. The association of stroke-induced immunosuppression with brain injury and s...
EXPRESS: Cerebroprotective effects of glutamate-oxaloacetate transaminase enzyme in ischemic stroke: systematic review and meta-analysis of preclinical studies [0.03%]
谷氨酸草酰乙酸转氨酶在缺血性脑卒中中的脑保护作用：前期研究的系统评价和荟萃分析
Antonio Dopico-López,Mikahela A López-Morales,María C Burguete et al.
Antonio Dopico-López et al.
While independent preclinical studies have reported beneficial effects of glutamate-oxaloacetate transaminase (GOT) in models of ischemic stroke, these findings remain dispersed across the literature. This PRISMA-compliant systematic review...
EXPRESS: Oridonin inhibits HIF-1α ubiquitination by targeting PHD2 in oligodendrocyte precursor cells to promote angiogenesis after ischemic stroke [0.03%]
奥瑞甘素通过作用于少突胶质前体细胞中的PHD2抑制HIF-1α泛素化促进缺血性卒中后血管新生
Wei Guo,Shuqi Cheng,Yanyan Liu et al.
Wei Guo et al.
Background: Angiogenesis during post-stroke neurovascular recovery is linked to oligodendrocyte precursor cells (OPCs) phenotypic shifts. Oridonin, a natural diterpenoid, has the potential to regulate post-stroke angiogen...
EXPRESS: Downregulation of Trpv4 and Klf2 in brain microvessels is associated with the progression of neurovascular dysfunction and cognitive impairment in a model of heart failure with preserved ejection fraction [0.03%]
特刊：Trpv4和Klf2在大脑微血管中的下调与心脏瓣膜病保留射血分数模型中神经血管功能障碍和认知障碍进展有关
Sara M P Lambrichts,Laura van der Taelen,Irene Pastor et al.
Sara M P Lambrichts et al.
Vascular cognitive impairment (VCI) shares major risk factors with heart failure with preserved ejection fraction (HFpEF), including obesity, diabetes and hypertension. Yet VCI research often relies on single-stimulus models, whereas patien...
EXPRESS: Endothelial-specific ACKR1 overexpression attenuates macrophage infiltration and blood-brain barrier disruption after ischemic stroke [0.03%]
特异性内皮过表达ACKR1在缺血性脑卒中后减少巨噬细胞浸润和血脑屏障破坏
Mengyuan Guo,Haoyi Fang,Siyan Tang et al.
Mengyuan Guo et al.
Ischemic stroke triggers a profound inflammatory response that exacerbates secondary brain injury, with infiltrating macrophages serving as major pathological mediators. Although previous studies have largely focused on immune cell-intrinsi...
EXPRESS: Effects of prolonged fixation on vascular biomarkers in postmortem human brains [0.03%]
死后人脑长时间固定对血管生物标志物的影响
Eve-Marie Frigon,Weiya Ma,Cecilia Tremblay et al.
Eve-Marie Frigon et al.
Postmortem human brains are important research resources to study the mechanisms underlying cerebrovascular features in various neurodegenerative disorders. Immunohistochemical and histochemical staining have been used to examine human brai...
EXPRESS: A longitudinal investigation of locus coeruleus norepinephrine system integrity and cognitive performance across the Alzheimer's spectrum [0.03%]
横断面和纵向研究发现阿尔茨海默病患者蓝斑去甲肾上腺素系统的完整性受损
Ahmad Sibahi,Seyyed Ali Hosseini,Nesrine Rahmouni et al.
Ahmad Sibahi et al.
Loss of locus coeruleus (LC) integrity, a debilitating feature of Alzheimer's disease (AD), can be visualized in vivo with MRI. Longitudinal investigation across the AD spectrum can elucidate the timing of LC damage and its behavioral corre...
EXPRESS: BOLD-based cerebrovascular reactivity is influenced by baseline cerebral blood volume and oxygen metabolism in humans [0.03%]
基于BOLD的脑血管反应性受基线脑血量和氧代谢的影响人类中的研究
Gabriel Hoffmann,Lena Schmitzer,Jan Kufer et al.
Gabriel Hoffmann et al.
Cerebrovascular reactivity (CVR) is a key indicator of vascular health. It is typically assessed using a vasoactive stimulus such as hypercapnia while recording perfusion changes using Blood Oxygenation Level Dependent (BOLD) Magnetic Reson...