EXPRESS: Hierarchical Chromatin Rewiring Orchestrates Early Transcriptional Regulation in Mouse Cerebral Cortex Following Focal Ischemia [0.03%]
缺血后小鼠大脑皮层早期 transcriptional regulation 的机制研究：基于染色体的层次结构重排模型
Hadjer Namous,Raghu Vemuganti
Hadjer Namous
Ischemic stroke triggers rapid, spatiotemporally orchestrated transcriptional reprogramming, yet the mechanisms conferring selective gene expression under acute stress remain poorly understood. Here, we examine how genome architecture dynam...
EXPRESS: FDG: Five Decades of Transforming Molecular Imaging and Still Illuminating the Brain [0.03%]
FDG: 改变分子影像五十载仍照亮未来神经系统研究道路
Shokouh Arjmand,Paul Cumming,Albert Gjedde
Shokouh Arjmand
Over half a century after its introduction, [18F]fluorodeoxyglucose ([18F]FDG) remains a cornerstone of molecular imaging by positron emission tomography (PET). This commentary reflects on [18F]FDG-PET's transformative role in neuroscience,...
EXPRESS: Activation of GPR17 ameliorates neuroinflammation and improves neurological function via NF-κB pathway in an experimental germinal matrix hemorrhage rat model [0.03%]
小胶质细胞GPR17通过NF-κB信号通路改善早产儿脑室内出血的神经功能和神经炎症
Chenxi Guo,Fengmei Zhou,Chi Qin et al.
Chenxi Guo et al.
Germinal matrix hemorrhage (GMH), a major complication of prematurity, involves severe neuroinflammation leading to neurological deficits. While G protein-coupled receptor 17 (GPR17) is known to modulate neuroinflammation, its therapeutic p...
EXPRESS: Kinetic modeling of the Tropomyosin Receptor Kinases radioligand [18F]TRACK in human brain with high-resolution positron emission tomography [0.03%]
简讯：利用高分辨率正电子发射断层扫描对人体大脑中的Tropomyosin受体激酶放射配体[18F] TRACK进行动力学建模
Christian Ramos-Jiménez,Kankana Nisha Aji,Chris Hung-Hsin Hsiao et al.
Christian Ramos-Jiménez et al.
Tropomyosin receptor kinases family members TrkA, TrkB and TrkC mediate critical processes, such as neuronal growth, survival, and synaptic plasticity, and have been implicated in neuropsychiatric disorders. In this work, we characterized t...
EXPRESS: Fibroblast Activation Protein Protects the Ischemic Brain Through Regulation of Post-Ischemic Inflammation [0.03%]
缺血性脑卒中后通过调节炎症激活蛋白发挥保护作用
Nan Ju,Chin Yang Chang,Hiroki Hayashi et al.
Nan Ju et al.
Low circulating levels of soluble fibroblast activation protein (sFAP) are associated with poor outcomes in patients with ischemic stroke, while its function in the ischemic brain remains unclear. This study investigated the role of FAP in ...
EXPRESS: The modified Hijdra scale for prediction of delayed cerebral infarcts after subarachnoid hemorrhage [0.03%]
改良Hijdra评分预测动脉瘤性蛛网膜下腔出血后迟发脑梗死的效果研究
Vasilis Kola,Prabin Basnet,Viktor Horst et al.
Vasilis Kola et al.
Delayed cerebral ischemia (DCI) occurs several days after subarachnoid hemorrhage (SAH) and could therefore be mitigated by treatment intervention. As testament to the great challenge of designing effective trials, however, the prevalence a...
EXPRESS: Microthrombi and Hypercoagulability's Contribution to Delayed Cerebral Ischemia after Aneurysmal Subarachnoid Hemorrhage [0.03%]
关于动脉瘤性蛛网膜下腔出血后延迟性脑缺血的微血栓和高凝状态的贡献
William Walker Wroe,Hussein A Zeineddine,Spiros Blackburn et al.
William Walker Wroe et al.
Despite increasing knowledge over the last several decades of the factors contributing to delayed cerebral ischemia (DCI), it remains a significant cause of morbidity after aneurysmal subarachnoid hemorrhage (aSAH). The hypercoagulable stat...
EXPRESS: Immunothrombosis: bridging endothelial dysfunction and no-reflow in ischemic stroke [0.03%]
免疫促凝：在缺血性卒中内皮功能障碍与慢流之间的桥梁作用
Jia Liu,Mengyuan Guo
Jia Liu
The successful clinical treatment of acute ischemic stroke pivots on reestablishing blood flow. After attempting recanalization, the "no-reflow" phenomenon undermines the long-term benefits of clot-busting strategies, including thrombolytic...
EXPRESS: SPI1 promotes endothelial cell ferroptosis and intracranial aneurysm progression via EP300-mediated FOSL2 acetylation [0.03%]
SPI1通过EP300介导的FOSL2乙酰化促进内皮细胞铁死亡和颅内动脉瘤进展
Lingfeng Lai,Zhifan Zheng,Hengyang Ouyang et al.
Lingfeng Lai et al.
This study investigates the role of SPI1 in the pathogenesis of intracranial aneurysm (IA). Results confirmed that SPI1 was significantly upregulated in both an in vivo mouse IA model and an in vitro model of angiotensin II-stimulated human...
EXPRESS: Astrocyte-Driven Multicellular Mechanisms of CNS Repair and Cerebroprotection [0.03%]
简讯：胶质细胞介导的中枢神经系统修复和脑保护的多细胞机制
Kristopher E Plambeck,Reina B Hastings,Elena Blanco-Suarez
Kristopher E Plambeck
Astrocytes are central regulators of brain homeostasis, which respond dynamically to injury and disease by modulating neuronal activity, immune responses, and vascular function. Recent work has revealed that the diversity of astrocytic stat...