EXPRESS: Post-Ischemic Sodium Glucose Cotransporter Inhibition Attenuates Ischemia-Reperfusion Injury via Regulation of Mitochondrial Membrane Potential [0.03%]
缺血再灌注损伤的新型抑制剂：钠葡萄糖共转运蛋白抑制剂通过调节线粒体膜电位起作用
Tomoya Okamaoto,Hiromitsu Sasaki,Yudai Morisaki et al.
Tomoya Okamaoto et al.
Purpose: Ischemia-reperfusion injury remains a major clinical challenge even after successful recanalization in stroke patients. Mitochondrial membrane potential plays a key role in the neuroprotective effect against isch...
EXPRESS: Glymphatic System Dysfunction and Neurological Disorders: From Mechanisms to Therapeutic Strategies [0.03%]
淋巴系统功能障碍与神经系统疾病：从机制到治疗策略
Zinan Guo,Mengying Dai,Shuo Song et al.
Zinan Guo et al.
Traditional neuroanatomy long asserted the absence of lymphatic circulation in the central nervous system, contradicting its high metabolic activity and efficient waste removal. This paradox was resolved in the 21st century by Iliff et al.,...
EXPRESS: Toll Like Receptor 4 (TLR4) in Neuroinflammation: From Acute Hemorrhagic Stroke to Chronic Neurodegeneration [0.03%]
髓样分化因子2和 toll 样受体4在脑缺血中的作用及机制研究进展
Hadi Hasan Choudhary,Jun Yoshida,Rezwanul Islam et al.
Hadi Hasan Choudhary et al.
Subarachnoid Hemorrhage (SAH) remains a leading cause of morbidity and mortality worldwide. While the primary injury is defined by mechanical tissue disruption, the progression of secondary brain injury is largely driven by robust neuroinfl...
EXPRESS: Ventricular CSF-to-blood water transport kinetics in adult hydrocephalus [0.03%]
成人脑积水的脑脊液-血液转运动力学研究
Per Kristian Eide,Alexander Gul Sherwani,Luis Romundstad et al.
Per Kristian Eide et al.
Water exchange between cerebrospinal fluid (CSF) and blood is fundamental to brain fluid homeostasis, yet ventricular CSF-to-blood water transport has never been quantified as a physiological parameter in adult humans. We investigated ventr...
EXPRESS: Intercellular Mitochondrial Transfer in Ischemic Stroke: Emerging Roles of Microglia [0.03%]
濒死细胞线粒体的释放与免疫监视及吞噬作用：神经炎症和中风后线粒体的质量控制
Hong Yang,Xinyu Sun,Jie Jiang et al.
Hong Yang et al.
Mitochondrial dysfunction is a central driver of injury following cerebral ischemia-reperfusion, linking energy failure, oxidative stress, and inflammation. Intercellular mitochondrial transfer has been proposed as an adaptive mechanism to ...
EXPRESS: Mechanical Compaction Alters Microstructural and Magnetic Resonance Imaging Properties of Acute Ischemic Stroke Clots [0.03%]
急性缺血性卒中血栓的机械压缩改变了其微结构和磁共振特性
Cody Kubicki,Thomas Neuberger,Scott Simon et al.
Cody Kubicki et al.
Background: Thrombolytic recanalization rates in acute ischemic stroke (AIS) patients remain low. Magnetic resonance susceptibility vessel sign has been correlated with reduced thrombolytic susceptibility. However, the dr...
EXPRESS: Multi-modal Magnetic Resonance Imaging to Assess Cerebrovascular Function in Patients with Atrial Fibrillation [0.03%]
多模态磁共振成像评估心房颤动患者脑血管功能
Harvey James Walsh,Catherine A Morgan,Mark Webster et al.
Harvey James Walsh et al.
Atrial fibrillation (AF) is associated with a high risk of stroke, as well as cognitive decline and dementia. Advanced imaging techniques were employed to test the hypothesis that AF worsens cerebrovascular function as evaluated using neuro...
EXPRESS: Trifluoperazine reduces infarct size, restores neurovascular coupling and improves early outcomes in experimental acute ischemic stroke [0.03%]
trifluoperazine减少梗死面积、恢复神经血管偶联并改善急性缺血性卒中实验模型早期预后
Réka Tóth,Anna Törteli,Melinda Szabó et al.
Réka Tóth et al.
Cerebral edema and neurovascular dysfunction are reliable predictors of outcome after acute ischemic stroke (AIS), yet effective targeted therapies remain limited. We investigated the therapeutic potential of trifluoperazine (TFP), an FDA-a...
Fan Yang,Vibha Balaji,Ziyuan Zhou et al.
Fan Yang et al.
Most neuroimaging applications involve a multi-step pipeline encompassing image acquisition, reconstruction, enhancement, registration, segmentation, diagnosis, and prognosis. These steps are fundamental for diagnosing neurological disorder...
EXPRESS: A scoping review of computational models on human glucose cerebral metabolism [0.03%]
基于人类葡萄糖脑代谢的计算模型的范围回顾研究(EXPRESS)
Parissa Fereydouni-Forouzandeh,Andréanne Michaud,Nicolas Doyon et al.
Parissa Fereydouni-Forouzandeh et al.
Understanding cerebral metabolism is an essential undertaking to address brain health and tackle ambiguities in associated neurodegenerative diseases. Despite the abundance of detailed observational findings on specific functionalities of m...