Persistent CO2 reactivity deficits are associated with neurological dysfunction up to one year after repetitive mild closed head injury in adolescent mice [0.03%]
重复轻度闭合性脑损伤后小鼠的CO2反应缺损和神经功能障碍可持续一年
Limin Wu,Suk-Tak Chan,William J Edmiston rd et al.
Limin Wu et al.
Cerebrovascular reactivity (CVR) deficits in adolescents with concussion may persist after resolution of neurological symptoms. Whether or not CVR deficits predict long term neurological function is unknown. We used adolescent mice closed h...
Endogenous zinc protoporphyrin formation critically contributes to hemorrhagic stroke-induced brain damage [0.03%]
内源性锌原卟啉的形成在出血性卒中诱导的脑损伤中的关键作用
Rong Pan,Song Yu,Haikun Zhang et al.
Rong Pan et al.
Hemorrhagic stroke is a leading cause of death. The causes of intracerebral hemorrhage (ICH)-induced brain damage are thought to include lysis of red blood cells, hemin release and iron overload. These mechanisms, however, have not proven v...
Eleonora Napoli,Alexios A Panoutsopoulos,Patricia Kysar et al.
Eleonora Napoli et al.
Autophagy is essential to cell function, as it enables the recycling of intracellular constituents during starvation and in addition functions as a quality control mechanism by eliminating spent organelles and proteins that could cause cell...
You Jeong Park,Cesar V Borlongan
You Jeong Park
The last 50 years have witnessed the translation of stem cell therapy from the laboratory to the clinic for treating brain disorders, in particular stroke. From the focal stereotaxic transplantation to the minimally invasive intravenous and...
Cortical cerebral microinfarcts on 7T MRI: Risk factors, neuroimaging correlates and cognitive functioning - The Medea-7T study [0.03%]
基于7T磁共振的皮层脑微梗死的风险因素、影像学关联及认知功能：Medea-7T研究
Maarten Ht Zwartbol,Ina Rissanen,Rashid Ghaznawi et al.
Maarten Ht Zwartbol et al.
We determined the occurrence and association of cortical cerebral microinfarcts (CMIs) at 7 T MRI with risk factors, neuroimaging markers of small and large vessel disease, and cognitive functioning. Within the Medea-7T study, a diverse coh...
Repeated hypoxia exposure induces cognitive dysfunction, brain inflammation, and amyloidβ/ p-Tau accumulation through reduced brain O-GlcNAcylation in zebrafish [0.03%]
重复缺氧暴露通过降低脑O-GlcNAc酰化在斑马鱼中诱导认知障碍、大脑炎症和淀粉样蛋白β/p-Tau聚集
Jiwon Park,Sunhee Jung,Sang-Min Kim et al.
Jiwon Park et al.
Repetitive hypoxia (RH) exposure affects the initiation and progression of cognitive dysfunction, but little is known about the mechanisms of hypoxic brain damage. In this study, we show that sublethal RH increased anxiety, impaired learnin...
Review of treatment and therapeutic targets in brain arteriovenous malformation [0.03%]
脑动静脉畸形的治疗及治疗靶点分析评论
Peipei Pan,Shantel Weinsheimer,Daniel Cooke et al.
Peipei Pan et al.
Brain arteriovenous malformations (bAVM) are an important cause of intracranial hemorrhage (ICH), especially in younger patients. The pathogenesis of bAVM are largely unknown. Current understanding of bAVM etiology is based on studying gene...
Selective intra-carotid blood cooling in acute ischemic stroke: A safety and feasibility study in an ovine stroke model [0.03%]
急性缺血性卒中患者颈内动脉选择性脑部降温的安全性和可行性研究：绵羊卒中模型中的研究
Giorgio Fm Cattaneo,Andrea M Herrmann,Sebastian A Eiden et al.
Giorgio Fm Cattaneo et al.
Selective therapeutic hypothermia (TH) showed promising preclinical results as a neuroprotective strategy in acute ischemic stroke. We aimed to assess safety and feasibility of an intracarotid cooling catheter conceived for fast and selecti...
Tissue outcome prediction in hyperacute ischemic stroke: Comparison of machine learning models [0.03%]
基于机器学习的模型预测急性缺血性脑卒中患者的组织结局比较
Joseph Benzakoun,Sylvain Charron,Guillaume Turc et al.
Joseph Benzakoun et al.
Machine Learning (ML) has been proposed for tissue fate prediction after acute ischemic stroke (AIS), with the aim to help treatment decision and patient management. We compared three different ML models to the clinical method based on diff...
[11C]PBR28 radiotracer kinetics are not driven by alterations in cerebral blood flow [0.03%]
［11C］PBR28放射示踪剂动力学不由脑血流改变驱动
Christin Y Sander,Stefano Bovo,Angel Torrado-Carvajal et al.
Christin Y Sander et al.
The positron emission tomography (PET) radiotracer [11C]PBR28 has been increasingly used to image the translocator protein (TSPO) as a marker of neuroinflammation in a variety of brain disorders. Interrelatedly, similar clinical populations...