Comparing kinetic profiles of SV2A radiotracers [18F]SynVesT-1 and [18F]UCB-J using PET imaging in mice [0.03%]
比较PET成像在小鼠中SV2A放射配体[18F]SynVesT-1和[18F]UCB-J的动力学谱图
Liesbeth Everix,Alan Miranda,Jordy Akkermans et al.
Liesbeth Everix et al.
Deficits in the synaptic vesicle protein 2A (SV2A) have been reported in various neurodegenerative diseases including Alzheimer's and Huntington's disease (HD). SV2A levels can be investigated using positron emission tomography (PET) radiol...
Gustav Magnusson,Alex A Bhogal,Charalampos Georgiopoulos et al.
Gustav Magnusson et al.
Cerebrovascular reactivity (CVR) is increasingly recognized as a valuable clinical biomarker, making accurate, and reliable quantification essential, particularly in the absence of a gold-standard reference. However, both the acquisition an...
Rajat Dhar
Rajat Dhar
Imaging after ischemic and hemorrhagic stroke may allow measurement of key phenotypes of injury and recovery for which targeted therapies are still lacking. Such imaging endophenotypes provide quantifiable and heritable biomarkers that can ...
Direct glia-to-neuron conversion mitigates hippocampal damage in a vascular dementia mouse model [0.03%]
胶质细胞直接重编程改善血管性痴呆小鼠海马损伤
Ricardo Satoshi Ota-Elliott,Yusuke Fukui,Xinran Hu et al.
Ricardo Satoshi Ota-Elliott et al.
Vascular dementia, which is considered the second most common cause of dementia, has consistently remained a worldwide health concern. One possible approach to improving vascular dementia is by inducing neurogenesis. The asymmetric carotid ...
The role of dopamine decline, astrocyte reactivity, and cerebral small-vessel disease in cognitive aging [0.03%]
多巴胺减少、星形胶质细胞活化和小血管疾病在认知老化中的作用
Vanessa Crine,Jarkko Johansson,Olivia Ericsson et al.
Vanessa Crine et al.
Several aging-related brain changes have been associated with unsuccessful cognitive aging, including dopamine decline, increased astrocyte reactivity, and cerebral small-vessel disease (SVD). We hypothesized that dopamine decline is exacer...
Neuroinflammation in vascular cognitive impairment and dementia: Insights from clinical biomarkers and experimental models [0.03%]
血管性认知障碍和痴呆的神经炎症：来自临床生物标志物和实验模型的见解
Akane Mizutani,Carlos Parra-Pérez,Akihiro Shindo et al.
Akane Mizutani et al.
Vascular cognitive impairment and dementia (VCID) encompasses a heterogeneous group of disorders in which cerebrovascular pathology contributes to cognitive decline. Accumulating evidence from both clinical and basic studies suggests that n...
Optimized reference region and the effect on test-retest reliability and sensitivity to differences between Parkinson's disease and control groups with [11C]UCB-J [0.03%]
优化的参考区域及对帕金森病与正常对照组间[11C]UCB-J差异敏感性的影响——测试-重测信度分析
Nikkita Khattar,David Matuskey,Jean-Dominique Gallezot et al.
Nikkita Khattar et al.
[11C]UCB-J is a radioligand targeting synaptic vesicle glycoprotein 2A, used to image synaptic density. For quantification, a small-volume centrum semiovale area was previously optimized as a [11C]UCB-J reference region (CS2mL); however, du...
Single-cell transcriptomics brings stroke thrombi into cellular and molecular focus: A commentary on "characterizing stroke clots using single-cell sequencing" [0.03%]
单细胞转录组学使卒中血栓的细胞和分子特征成为焦点：关于“使用单细胞测序表征卒中血栓”的评论
Fang Yu,Nishitha Bujala,Sangharsha Thapa et al.
Fang Yu et al.
Single-cell transcriptomic profiling of human ischemic stroke thrombi represents a major advance in our understanding of cerebrovascular pathobiology. In their recent study, Renedo et al. applied single-cell RNA sequencing to thrombectomy-r...
Commentary to "Ischemic conditioning promotes transneuronal survival and stroke recovery via CD36-mediated efferocytosis" [0.03%]
「缺血预处理通过CD36介导的efferocytosis促进跨神经元存活和卒中恢复」一文述评
Jaroslaw Aronowski
Jaroslaw Aronowski
Remote ischemic postconditioning (RIC) has emerged as a novel promising intervention to reduce damage after stroke. However, the mechanisms underlying the beneficial effect of RIC are unclear. The recent study using ischemic stroke in mice ...
Cerebral small vessel disease burden relates to cognitive decline via impaired amyloid clearance in the general population [0.03%]
一般人群中的脑小血管疾病负担通过淀粉样蛋白清除功能障碍与认知下降有关
Chi-Heng Zhou,Fei Han,Feng Gao et al.
Chi-Heng Zhou et al.
Our aim is to examine the interplay between cerebral small vessel disease (CSVD) pathology, Alzheimer's disease (AD) related amyloid-β (Aβ) clearance, and cognition in general population. Cross-sectional structural equation modeling (SEM)...