A qualitative prognostic biomarker for melanoma based on the relative methylation orderings of CpG loci [0.03%]
基于CpG位点相对甲基化顺序的黑色素瘤定性预后生物标志物
Yue Huo,Yaru Gao,Jiayi Ruan et al.
Yue Huo et al.
Skin cutaneous melanoma (SKCM) is an aggressive tumor with a poor prognosis. We developed SKCM-P8, a novel qualitative prognostic biomarker based on the relative methylation orderings of eight pairs of loci. Analysis of a training cohort an...
CircMYH9 promotes the mRNA stability of SPAG6 by recruiting EIF4A3 to facilitate the progression of breast cancer [0.03%]
circMYH9通过招募EIF4A3来促进SPAG6的mRNA稳定性以促进乳腺癌进展
Shanji Fan,Ying Cui,Yingjie Liu et al.
Shanji Fan et al.
The incidence rate of breast cancer (BC) ranks first among female malignant tumors. Late-stage BC patients are at risk of death from distant metastasis. Circular RNAs (circRNAs) play an important function in cancer development. This study l...
Differential methylation in blood pressure control genes is associated to essential hypertension in African Brazilian populations [0.03%]
与非洲巴西人群血压控制基因的差异甲基化有关的本质性高血压问题研究
Camila Cristina Avila Martins,Mariana Maschietto,Lilian Kimura et al.
Camila Cristina Avila Martins et al.
While genetic studies have provided insights into essential hypertension (EH, defined by high blood pressure ≥140/90 mmHg), investigation through epigenetics may address gaps in understanding its heritability. This study focused on African...
Comprehensive analysis of eccDNA characteristics and associated genes expression in peripheral blood of ASLE and ISLE patients [0.03%]
ASLE和ISLE患者外周血eccDNA特征及其相关基因表达的综合分析
Yali Peng,Huihui Tao,Dongzhou Liu et al.
Yali Peng et al.
To explore SLE staging markers, we analyzed eccDNA in plasma using circular sequencing, comparing healthy controls (HC), active SLE (ASLE), and inactive SLE (ISLE) patients. We found higher eccDNA levels and lower GC content in ASLE and ISL...
Placental malaria induces a unique methylation profile associated with fetal growth restriction [0.03%]
胎盘疟疾诱导与胎儿生长受限相关的独特甲基化谱型
Nida Ozarslan,Corina Mong,John Ategeka et al.
Nida Ozarslan et al.
Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well as long-term complications, including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases in adulthood...
Single and multi-omic characterization of a porcine model of ethanol-induced hepatic fibrosis [0.03%]
猪乙醇诱导肝纤维化模型的单组学和多组学特征分析
Mark Hieromnimon,Daniel P Regan,R Peter Lokken et al.
Mark Hieromnimon et al.
Cirrhosis is a form of end-stage liver disease characterized by extensive hepatic fibrosis and loss of liver parenchyma. It is most commonly the result of long-term alcohol abuse in the United States. Large animal models of cirrhosis, as we...
SIRT1/DNMT3B-mediated epigenetic gene silencing in response to phytoestrogens in mammary epithelial cells [0.03%]
植物雌激素诱导的乳腺上皮细胞中SIRT1 / DNMT3B介导的表观遗传基因沉默响应
Yuexi Ma,Cayla Boycott,Jiaxi Zhang et al.
Yuexi Ma et al.
We performed an integrated analysis of genome-wide DNA methylation and expression datasets in normal cells and healthy animals exposed to polyphenols with estrogenic activity (i.e. phytoestrogens). We identified that phytoestrogens target g...
TET-mediated 5hmC in breast cancer: mechanism and clinical potential [0.03%]
乳腺癌中的TET介导的5hmC：机制及其临床潜力
Jiahang Zhang,Nadire Aishan,Zhongqiu Zheng et al.
Jiahang Zhang et al.
Breast cancer is the most common cancer among women, with differences in clinical features due to its distinct molecular subtypes. Current studies have demonstrated that epigenetic modifications play a crucial role in regulating the progres...
A polyepigenetic glucocorticoid exposure score and HPA axis-related DNA methylation are associated with gestational epigenetic aging [0.03%]
多表观遗传糖皮质激素暴露分数和与HPA轴相关的DNA甲基化与妊娠表观遗传衰老有关
Allison A Appleton
Allison A Appleton
Gestational epigenetic aging (GEA) is a novel approach for characterizing associations between prenatal exposures and postnatal risks. Psychosocial adversity in pregnancy may influence GEA, but the molecular mechanisms are not well understo...
Olukunle Akinborewa,Mattia Quattrocelli
Olukunle Akinborewa
The glucocorticoid receptor (GR) is a critical nuclear receptor that regulates gene expression in diverse tissues, including the heart, where it plays a key role in maintaining cardiovascular health. GR signaling influences essential proces...