The technology landscape for detection of DNA methylation in cancer liquid biopsies [0.03%]
癌症液体活检中检测DNA甲基化的技术现状
Isabelle Neefs,Joe Ibrahim,Marc Peeters et al.
Isabelle Neefs et al.
DNA methylation is a well-studied epigenetic factor and has become a powerful player in the cancer biomarker research field. Together with the rising interest in methylation biomarkers, the technological advances for the detection of DNA me...
Strength of evidence for paternal influence on offspring epigenome in observational human studies: a systematic review and risk-of-bias appraisal for non-randomized exposures [0.03%]
人类观察性研究中父亲对子代表观基因组影响的证据强度：非随机暴露的风险偏倚评估系统评价
Ka Kei Sum,Mark A Burton,Cristina Garcia-Maurino Alcazar et al.
Ka Kei Sum et al.
Paternal influence on the offspring epigenome is difficult to interpret in observational human studies due to heterogeneous designs, causing varying susceptibility to bias and non-causal explanations. We conducted a systematic review (CRD42...
Exploring the association between DNA methylation and pancreatic cancer susceptibility through epigenome-wide Mendelian randomization and multi-omics data integration [0.03%]
基于孟德尔随机化和多组学数据整合探讨DNA甲基化与胰腺癌易感性的关联
Pengxu Wang,Feng Rong,Fubao Liu
Pengxu Wang
Investigating the role of DNA methylation in the development of pancreatic cancer (PC) may facilitate identification of potential targets for both diagnosis and treatment. We carried out a comprehensive epigenome-wide Mendelian randomizatio...
Meta-Analysis
Epigenetics. 2025 Dec;20(1):2599682. DOI:10.1080/15592294.2025.2599682 2025
Anesthetic-induced epigenetic alterations: mechanisms and long-term clinical implications [0.03%]
麻醉诱导的表观遗传学改变：机制及长期临床意义
Elham Shahidi Delshad,Afzal Shamsi,Mahdieh Mehrab Mohseni et al.
Elham Shahidi Delshad et al.
This review explores how anesthetic agents influence epigenetic mechanisms such as DNA methylation, histone modifications, and non-coding RNA expression, and their lasting clinical effects. Common anesthetics, including propofol, isoflurane...
Changes in nuclear and mitochondrial DNA methylation in cow blood associated with age and disease [0.03%]
与年龄和疾病相关的牛血液核DNA和线粒体DNA甲基化变化
Lotfi Bouzeraa,Camila Bruna de Lima,Helene Martin et al.
Lotfi Bouzeraa et al.
DNA methylation is among the most promising biomarkers for age prediction, enabling the development of epigenetic clocks that correlate methylation profiles with chronological age. In this study, we investigated the relationship between age...
Crosstalk between skeletal muscle and the brain during physical activity - in search of epigenetic mechanisms [0.03%]
运动过程中骨骼肌与大脑的相互作用——寻找表观遗传机制
Cayla Boycott,Ewa Kilanczyk,Huiying A Zhang et al.
Cayla Boycott et al.
Recent research highlights the crucial role of muscle-brain crosstalk in metabolic regulation, particularly in individuals with type 2 diabetes and obesity. Myokines, protein hormones secreted by skeletal muscle, play a crucial role in this...
Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure [0.03%]
小鼠心脏疾病和人类心力衰竭中心.histone h4k20甲基化及其相关酶的表达谱分析
Samuel Hickenlooper,Cameron Brady,Ryan Bia et al.
Samuel Hickenlooper et al.
Histone H4K20 methylation is critical in regulating the cell cycle, DNA damage response, and gene repression in proliferating cells. However, its role in the heart remains poorly understood. Our previous work revealed that histone H4K20 tri...
The multifaceted role of lactate in cardiovascular health: from metabolism to signaling and epigenetics [0.03%]
乳酸在心血管健康中的多重作用：从代谢到信号传导和表观遗传学
J Konieczny,N Boardman,E Aasum et al.
J Konieczny et al.
Lactate, long regarded as a metabolic byproduct of anaerobic glycolysis, has emerged as a key regulator of cardiovascular health. Its roles extend beyond energy metabolism and include cell signaling through hydroxycarboxylic acid receptor 1...
Integrative DNA methylation and transcriptome analysis reveal cell-type specific patterns in response to elevated allostatic load [0.03%]
整合DNA甲基化和转录组分析揭示了对升高的心理社会压力的细胞类型特异性反应模式
O Emery,C Carmeli,S Gonseth-Nusslé et al.
O Emery et al.
Allostatic load (AL) is a measure of the body's multi-systemic physiological dysregulation in response to chronic stress and life events. High AL has been associated with poor long-term health outcomes such as cardiovascular disease and mor...
Methylation differences between assisted reproductive technology-conceived and naturally conceived children near BRCA1 and NBR2 [0.03%]
辅助生殖技术受孕的儿童和自然受孕的儿童在BRCA1和NBR2附近的甲基化差异
Yunsung Lee,Håkon Kristian Gjessing,Christian Magnus Page et al.
Yunsung Lee et al.
Recent studies have shown that newborns conceived using assisted reproductive technology (ART) exhibited significantly different DNA methylation (DNAm) profiles at birth compared to those conceived naturally. Of note was the observation of ...