Comprehensive analysis of eccDNA characteristics and associated genes expression in peripheral blood of ASLE and ISLE patients [0.03%]
ASLE和ISLE患者外周血eccDNA特征及其相关基因表达的综合分析
Yali Peng,Huihui Tao,Dongzhou Liu et al.
Yali Peng et al.
To explore SLE staging markers, we analyzed eccDNA in plasma using circular sequencing, comparing healthy controls (HC), active SLE (ASLE), and inactive SLE (ISLE) patients. We found higher eccDNA levels and lower GC content in ASLE and ISL...
Placental malaria induces a unique methylation profile associated with fetal growth restriction [0.03%]
胎盘疟疾诱导与胎儿生长受限相关的独特甲基化谱型
Nida Ozarslan,Corina Mong,John Ategeka et al.
Nida Ozarslan et al.
Fetal growth restriction (FGR) is associated with perinatal death and adverse birth outcomes, as well as long-term complications, including increased childhood morbidity, abnormal neurodevelopment, and cardio-metabolic diseases in adulthood...
Single and multi-omic characterization of a porcine model of ethanol-induced hepatic fibrosis [0.03%]
猪乙醇诱导肝纤维化模型的单组学和多组学特征分析
Mark Hieromnimon,Daniel P Regan,R Peter Lokken et al.
Mark Hieromnimon et al.
Cirrhosis is a form of end-stage liver disease characterized by extensive hepatic fibrosis and loss of liver parenchyma. It is most commonly the result of long-term alcohol abuse in the United States. Large animal models of cirrhosis, as we...
SIRT1/DNMT3B-mediated epigenetic gene silencing in response to phytoestrogens in mammary epithelial cells [0.03%]
植物雌激素诱导的乳腺上皮细胞中SIRT1 / DNMT3B介导的表观遗传基因沉默响应
Yuexi Ma,Cayla Boycott,Jiaxi Zhang et al.
Yuexi Ma et al.
We performed an integrated analysis of genome-wide DNA methylation and expression datasets in normal cells and healthy animals exposed to polyphenols with estrogenic activity (i.e. phytoestrogens). We identified that phytoestrogens target g...
TET-mediated 5hmC in breast cancer: mechanism and clinical potential [0.03%]
乳腺癌中的TET介导的5hmC：机制及其临床潜力
Jiahang Zhang,Nadire Aishan,Zhongqiu Zheng et al.
Jiahang Zhang et al.
Breast cancer is the most common cancer among women, with differences in clinical features due to its distinct molecular subtypes. Current studies have demonstrated that epigenetic modifications play a crucial role in regulating the progres...
A polyepigenetic glucocorticoid exposure score and HPA axis-related DNA methylation are associated with gestational epigenetic aging [0.03%]
多表观遗传糖皮质激素暴露分数和与HPA轴相关的DNA甲基化与妊娠表观遗传衰老有关
Allison A Appleton
Allison A Appleton
Gestational epigenetic aging (GEA) is a novel approach for characterizing associations between prenatal exposures and postnatal risks. Psychosocial adversity in pregnancy may influence GEA, but the molecular mechanisms are not well understo...
Olukunle Akinborewa,Mattia Quattrocelli
Olukunle Akinborewa
The glucocorticoid receptor (GR) is a critical nuclear receptor that regulates gene expression in diverse tissues, including the heart, where it plays a key role in maintaining cardiovascular health. GR signaling influences essential proces...
Normal bronchial field basal cells show persistent methylome-wide impact of tobacco smoking, including in known cancer genes [0.03%]
正常支气管场基底细胞显示出对烟草烟雾的广泛甲基化影响，包括已知的癌症基因中
Batbayar Khulan,Kenny Ye,Miao Kevin Shi et al.
Batbayar Khulan et al.
Lung carcinogenesis is causally linked to cigarette smoking, in part by epigenetic changes. We tested whether accumulated epigenetic change in smokers is apparent in bronchial basal cells as cells of origin of squamous cell carcinoma. Using...
Poly-epigenetic scores for cardiometabolic risk factors interact with demographic factors and health behaviors in older US Adults [0.03%]
多项表观遗传评分与老年美国成年人的心血管代谢风险因素的人口统计学特征和健康行为相互影响
Lisha Lin,Wei Zhao,Zheng Li et al.
Lisha Lin et al.
Poly-epigenetic scores (PEGS) are surrogate measures that help capture individual-level risk. Understanding how the associations between PEGS and cardiometabolic risk factors vary by demographics and health behaviors is crucial for lowering...
METTL14-mediated m6A modification of DDIT4 promotes its mRNA stability in aging-related idiopathic pulmonary fibrosis [0.03%]
METTL14介导的DDIT4mRNA上m6A修饰促进其稳定性并参与特发性肺纤维化中的异常蛋白质翻译调控
Dan Li,Li Qian,Yufeng Du et al.
Dan Li et al.
Although N6-methyladenosine (m6A) may be related to the pathogenesis of fibrotic process, the mechanism of m6A modification in aging-related idiopathic pulmonary fibrosis (IPF) remains unclear. Three-milliliter venous blood was collected fr...