Transcriptional signature of cardiac myocyte recovery in mice and human reveals persistent upregulation of epigenetic factors [0.03%]
小鼠和人类心肌细胞复苏的转录特征显示表观遗传因素持续上调
Rebekka Roth,Margareta Häckh,Tilman Schnick et al.
Rebekka Roth et al.
Fibrosis, cardiac remodelling, and inflammation are hallmarks of heart failure. To date, there is no available pharmacological cure for heart failure, but mechanical unloading by implantation of a left ventricular assist device (LVAD) can l...
A novel lncRNA, Lnc21q22.11, suppresses gastric cancer growth by inhibiting MEK/ERK pathway [0.03%]
新型长链非编码RNA(Lnc21q22.11)通过抑制MEK/ERK通路来抑制胃癌生长
Cheng Zhu,Meiying Zhang,Weili Yang et al.
Cheng Zhu et al.
Gastric cancer (GC) is one of the most common malignancies with limited treatment options and poor prognosis. Therefore, it is necessary to identify new markers for the development of novel therapeutic strategies. Long non-coding RNAs (lncR...
Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta [0.03%]
脐带血和胎盘的表观遗传特征：来自脐带血和胎盘的母体-胎儿健康的新见解
Jagadeesh Puvvula,Joseph M Braun,Emily A DeFranco et al.
Jagadeesh Puvvula et al.
The placenta is vital for fetal growth, and its methylation patterns reflect placental function, affecting the fetus and providing insights into disease origins. While cord blood methylation is convenient for assessing the fetal environment...
PRMT1 promotes immune escape in hepatocellular carcinoma by regulating arginine methylation modification of MYC protein [0.03%]
PRMT1通过调节MYC蛋白精氨酸甲基化促进肝癌免疫逃逸
Han Zhou,Yang Wang,Dan Wang et al.
Han Zhou et al.
Arginine methyltransferase 1 (PRMT1) is widely recognized as an oncogene in various cancers. However, its specific role and underlying mechanisms in hepatocellular carcinoma (HCC) remain insufficiently understood. This study investigated th...
Dennis Khodasevich,Anne K Bozack,Saher Daredia et al.
Dennis Khodasevich et al.
Epigenetic aging in early life remains poorly characterized, and patterns of gene expression can provide biologically meaningful insights. Blood DNA methylation was measured using the Illumina EPICv1.0 array and RNA sequencing was performed...
LncRNA SCARNA8 promotes atherosclerotic plaque instability by inhibiting macrophage efferocytosis [0.03%]
长链非编码RNA SCARNA8通过抑制巨噬细胞胞葬作用促进动脉粥样硬化斑块不稳定性
Xiaoliang Yin,Xiaodong Chen,Tao Wang et al.
Xiaoliang Yin et al.
In recent years, findings suggest that long noncoding RNAs (lncRNAs) are closely related to the development of atherosclerosis (AS), but there is a lack of studies on the involvement of lncRNA-regulated cytosolic burial in the regulation of...
Leilei Wen,Xiaojing Zhang,Qiaoshan Yang et al.
Leilei Wen et al.
Acute urticaria can be a presenting symptom of anaphylaxis characterized by transient red swellings or fulminant wheals, often accompanied by severe pruritus. Numerous studies have substantiated the important involvement of regulatory T cel...
Higher sperm H3K4me3 levels are associated with idiopathic recurrent pregnancy loss [0.03%]
表观遗传学修饰H3K4me3水平增高与复发性流产相关
Delna Irani,Deepshikha Arya,Deepti Tandon et al.
Delna Irani et al.
During fertilization, spermatozoa contribute genetic and epigenetic factors such as chromatin packaged with protamines and histones; DNA methylome, non-coding RNAs, etc. Human sperm chromatin retains 5-15% nucleosomes which can play a key r...
Acetaldehyde-driven mRNA methylation and expression changes in ethanol-metabolizing enzyme genes [0.03%]
乙醇代谢酶基因的甲基化和表达变化由醋酸醛驱动
Ji Sun Koo,Qiansheng Zhan,Huiping Zhang
Ji Sun Koo
This study examines how the alcohol metabolite acetaldehyde modulates mRNA methylation and expression of ethanol-metabolizing genes, uncovering its epigenetic role in ethanol metabolism. Using neuron-like (SH-SY5Y) and non-neuronal (SW620) ...
An overview of potential of natural compounds to regulate epigenetic modifications in colorectal cancer: a recent update [0.03%]
天然化合物调节结直肠癌表观遗传修饰的潜力概述：最新研究进展
Susmita Roy,Dikshita Deka,Suresh Babu Kondaveeti et al.
Susmita Roy et al.
Colorectal cancer (CRC) remains an alarming global health concern despite advancements in treatment modalities over recent decades. Among the various factors contributing to CRC, this review emphasizes the critical role of epigenetic mechan...